Brain functional changes in patients with botulism after illegal cosmetic injections of botulinum toxin: A resting-state fMRI study.
<h4>Background</h4>Botulinum toxin type A (BoNT-A) is generally considered safe and is widely used to treat a variety of clinical conditions involving muscle hyperactivity and for cosmetic purposes. However, the effects of BoNT-A poisoning (botulism) on brain function are poorly understo...
Main Authors: | , , , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2018-01-01
|
Series: | PLoS ONE |
Online Access: | https://doi.org/10.1371/journal.pone.0207448 |
id |
doaj-a5ead94b907a42c2a278111e81cc7e56 |
---|---|
record_format |
Article |
spelling |
doaj-a5ead94b907a42c2a278111e81cc7e562021-03-04T10:40:29ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-011311e020744810.1371/journal.pone.0207448Brain functional changes in patients with botulism after illegal cosmetic injections of botulinum toxin: A resting-state fMRI study.Ge-Fei LiShiyu BanMengxing WangJilei ZhangHaifeng LuYan-Hui ShiXin-Wei HeYi-Lan WuPeng PengYi-Sheng LiuMei-Ting ZhuangRong ZhaoXiao-Lei ShenQiang LiJian-Ren LiuXiaoxia Du<h4>Background</h4>Botulinum toxin type A (BoNT-A) is generally considered safe and is widely used to treat a variety of clinical conditions involving muscle hyperactivity and for cosmetic purposes. However, the effects of BoNT-A poisoning (botulism) on brain function are poorly understood.<h4>Methodology/principal findings</h4>Herein, we investigated brain functions in 9 patients who received illegal cosmetic injections of botulinum and 18 matched controls by combining the analysis methods of regional homogeneity (ReHo) and amplitude of low-frequency fluctuation (ALFF) based on resting-state fMRI. Compared with the controls, the patients with botulism exhibited significantly reduced ReHo values in the left posterior lobe of the cerebellum extending to the right anterior lobe of the cerebellum, as well as in the right anterior lobe of the cerebellum extending to the parahippocampal gyrus and right posterior lobe of the cerebellum. The patients with botulism also showed weakened ALFF values in the right anterior lobe of the cerebellum extending to the left anterior lobe of the cerebellum and right posterior lobe of the cerebellum, as well as in the right anterior lobe of the cerebellum.<h4>Conclusions/significance</h4>The results indicate that BoNT-A may modulate cerebral activation in specific areas, which may play roles in both the adverse effects of botulism and the mechanism underlying clinical treatment with BoNT-A.https://doi.org/10.1371/journal.pone.0207448 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ge-Fei Li Shiyu Ban Mengxing Wang Jilei Zhang Haifeng Lu Yan-Hui Shi Xin-Wei He Yi-Lan Wu Peng Peng Yi-Sheng Liu Mei-Ting Zhuang Rong Zhao Xiao-Lei Shen Qiang Li Jian-Ren Liu Xiaoxia Du |
spellingShingle |
Ge-Fei Li Shiyu Ban Mengxing Wang Jilei Zhang Haifeng Lu Yan-Hui Shi Xin-Wei He Yi-Lan Wu Peng Peng Yi-Sheng Liu Mei-Ting Zhuang Rong Zhao Xiao-Lei Shen Qiang Li Jian-Ren Liu Xiaoxia Du Brain functional changes in patients with botulism after illegal cosmetic injections of botulinum toxin: A resting-state fMRI study. PLoS ONE |
author_facet |
Ge-Fei Li Shiyu Ban Mengxing Wang Jilei Zhang Haifeng Lu Yan-Hui Shi Xin-Wei He Yi-Lan Wu Peng Peng Yi-Sheng Liu Mei-Ting Zhuang Rong Zhao Xiao-Lei Shen Qiang Li Jian-Ren Liu Xiaoxia Du |
author_sort |
Ge-Fei Li |
title |
Brain functional changes in patients with botulism after illegal cosmetic injections of botulinum toxin: A resting-state fMRI study. |
title_short |
Brain functional changes in patients with botulism after illegal cosmetic injections of botulinum toxin: A resting-state fMRI study. |
title_full |
Brain functional changes in patients with botulism after illegal cosmetic injections of botulinum toxin: A resting-state fMRI study. |
title_fullStr |
Brain functional changes in patients with botulism after illegal cosmetic injections of botulinum toxin: A resting-state fMRI study. |
title_full_unstemmed |
Brain functional changes in patients with botulism after illegal cosmetic injections of botulinum toxin: A resting-state fMRI study. |
title_sort |
brain functional changes in patients with botulism after illegal cosmetic injections of botulinum toxin: a resting-state fmri study. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2018-01-01 |
description |
<h4>Background</h4>Botulinum toxin type A (BoNT-A) is generally considered safe and is widely used to treat a variety of clinical conditions involving muscle hyperactivity and for cosmetic purposes. However, the effects of BoNT-A poisoning (botulism) on brain function are poorly understood.<h4>Methodology/principal findings</h4>Herein, we investigated brain functions in 9 patients who received illegal cosmetic injections of botulinum and 18 matched controls by combining the analysis methods of regional homogeneity (ReHo) and amplitude of low-frequency fluctuation (ALFF) based on resting-state fMRI. Compared with the controls, the patients with botulism exhibited significantly reduced ReHo values in the left posterior lobe of the cerebellum extending to the right anterior lobe of the cerebellum, as well as in the right anterior lobe of the cerebellum extending to the parahippocampal gyrus and right posterior lobe of the cerebellum. The patients with botulism also showed weakened ALFF values in the right anterior lobe of the cerebellum extending to the left anterior lobe of the cerebellum and right posterior lobe of the cerebellum, as well as in the right anterior lobe of the cerebellum.<h4>Conclusions/significance</h4>The results indicate that BoNT-A may modulate cerebral activation in specific areas, which may play roles in both the adverse effects of botulism and the mechanism underlying clinical treatment with BoNT-A. |
url |
https://doi.org/10.1371/journal.pone.0207448 |
work_keys_str_mv |
AT gefeili brainfunctionalchangesinpatientswithbotulismafterillegalcosmeticinjectionsofbotulinumtoxinarestingstatefmristudy AT shiyuban brainfunctionalchangesinpatientswithbotulismafterillegalcosmeticinjectionsofbotulinumtoxinarestingstatefmristudy AT mengxingwang brainfunctionalchangesinpatientswithbotulismafterillegalcosmeticinjectionsofbotulinumtoxinarestingstatefmristudy AT jileizhang brainfunctionalchangesinpatientswithbotulismafterillegalcosmeticinjectionsofbotulinumtoxinarestingstatefmristudy AT haifenglu brainfunctionalchangesinpatientswithbotulismafterillegalcosmeticinjectionsofbotulinumtoxinarestingstatefmristudy AT yanhuishi brainfunctionalchangesinpatientswithbotulismafterillegalcosmeticinjectionsofbotulinumtoxinarestingstatefmristudy AT xinweihe brainfunctionalchangesinpatientswithbotulismafterillegalcosmeticinjectionsofbotulinumtoxinarestingstatefmristudy AT yilanwu brainfunctionalchangesinpatientswithbotulismafterillegalcosmeticinjectionsofbotulinumtoxinarestingstatefmristudy AT pengpeng brainfunctionalchangesinpatientswithbotulismafterillegalcosmeticinjectionsofbotulinumtoxinarestingstatefmristudy AT yishengliu brainfunctionalchangesinpatientswithbotulismafterillegalcosmeticinjectionsofbotulinumtoxinarestingstatefmristudy AT meitingzhuang brainfunctionalchangesinpatientswithbotulismafterillegalcosmeticinjectionsofbotulinumtoxinarestingstatefmristudy AT rongzhao brainfunctionalchangesinpatientswithbotulismafterillegalcosmeticinjectionsofbotulinumtoxinarestingstatefmristudy AT xiaoleishen brainfunctionalchangesinpatientswithbotulismafterillegalcosmeticinjectionsofbotulinumtoxinarestingstatefmristudy AT qiangli brainfunctionalchangesinpatientswithbotulismafterillegalcosmeticinjectionsofbotulinumtoxinarestingstatefmristudy AT jianrenliu brainfunctionalchangesinpatientswithbotulismafterillegalcosmeticinjectionsofbotulinumtoxinarestingstatefmristudy AT xiaoxiadu brainfunctionalchangesinpatientswithbotulismafterillegalcosmeticinjectionsofbotulinumtoxinarestingstatefmristudy |
_version_ |
1714805021838671872 |