MCP-1, CCR2 and CCR5 Polymorphisms in Tunisian Patients with Atopic Asthma
Chemokines and their receptors play an important role in the late inflammatory stage of asthma. In this study, we aimed to investigate polymorphisms of MCP-1 (CCL2), CCR2 and CCR5 which can affect qualitatively and/or quantitatively their production and thus influence both susceptibility and sev...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Tehran University of Medical Sciences
2013-03-01
|
Series: | Iranian Journal of Allergy, Asthma and Immunology |
Subjects: | |
Online Access: | https://ijaai.tums.ac.ir/index.php/ijaai/article/view/537 |
id |
doaj-a5ebc0f2a68846388cae006bc4368fb5 |
---|---|
record_format |
Article |
spelling |
doaj-a5ebc0f2a68846388cae006bc4368fb52020-11-25T04:08:34ZengTehran University of Medical SciencesIranian Journal of Allergy, Asthma and Immunology1735-15021735-52492013-03-01121502MCP-1, CCR2 and CCR5 Polymorphisms in Tunisian Patients with Atopic AsthmaTarak Dhaouadi0Imen Sfar1Hajer Aounallah-Skhiri2Saloua Jendoubi-Ayed3Hend Bouacha4Taieb Ben Abdallah5Yousr Gorgi6Laboratory of Research in Immunology of Renal Transplantation and Immunopathology, Charles Nicolle Hospital, Tunis El Manar University, Tunis, TunisiaLaboratory of Research in Immunology of Renal Transplantation and Immunopathology, Charles Nicolle Hospital, Tunis El Manar University, Tunis, TunisiaNational Institute of Public Health, Tunis, TunisiaLaboratory of Research in Immunology of Renal Transplantation and Immunopathology, Charles Nicolle Hospital, Tunis El Manar University, Tunis, TunisiaPneumonology Department, Charles Nicolle Hospital, Tunis, TunisiaLaboratory of Research in Immunology of Renal Transplantation and Immunopathology, Charles Nicolle Hospital, Tunis El Manar University, Tunis, TunisiaLaboratory of Research in Immunology of Renal Transplantation and Immunopathology, Charles Nicolle Hospital, Tunis El Manar University, Tunis, Tunisia Chemokines and their receptors play an important role in the late inflammatory stage of asthma. In this study, we aimed to investigate polymorphisms of MCP-1 (CCL2), CCR2 and CCR5 which can affect qualitatively and/or quantitatively their production and thus influence both susceptibility and severity of asthma and its clinical and biological features. MCP-1 (A/G -2518), CCR2 (+/64I), CCR5 (G/A -59029) and CCR5 (∆32)polymorphisms were evaluated by PCR in 107 Tunisian patients with asthma and 169 healthy controls. No significant association was found between the four investigated polymorphisms and asthma. Nevertheless the haplotype MCP1*AG/CCR2*+/+ was significantly l ess frequent in patients (20.5%) compared to controls (32.5%) (p=0.03; OR=0.54; 95% CI:0.29-0.98). Whereas no difference was observed in CCR2/CCR5 haplotypes between patients and controls. Analysis of polymorphisms with clinical and biological features showed that the concomitant presence of MCP-1*G/CCR2*64I alleles was less frequent in severe forms (4.34%) compared to moderate disease (12%) but the difference was not significant (p=0.27). No association was observed between the four polymorphisms and the presence of atopic rhinitis or atopic conjunctivitis and an elevated rate of serum IgE over 200 IU/ml. Additional effects of MCP-1 and its receptor CCR2 polymorphisms seem to be involved in disease susceptibility to asthma in Tunisian patients; nevertheless they could be protective against its severe forms. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/537AsthmaAtopyChemokinesMCP-1Polymorphism |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tarak Dhaouadi Imen Sfar Hajer Aounallah-Skhiri Saloua Jendoubi-Ayed Hend Bouacha Taieb Ben Abdallah Yousr Gorgi |
spellingShingle |
Tarak Dhaouadi Imen Sfar Hajer Aounallah-Skhiri Saloua Jendoubi-Ayed Hend Bouacha Taieb Ben Abdallah Yousr Gorgi MCP-1, CCR2 and CCR5 Polymorphisms in Tunisian Patients with Atopic Asthma Iranian Journal of Allergy, Asthma and Immunology Asthma Atopy Chemokines MCP-1 Polymorphism |
author_facet |
Tarak Dhaouadi Imen Sfar Hajer Aounallah-Skhiri Saloua Jendoubi-Ayed Hend Bouacha Taieb Ben Abdallah Yousr Gorgi |
author_sort |
Tarak Dhaouadi |
title |
MCP-1, CCR2 and CCR5 Polymorphisms in Tunisian Patients with Atopic Asthma |
title_short |
MCP-1, CCR2 and CCR5 Polymorphisms in Tunisian Patients with Atopic Asthma |
title_full |
MCP-1, CCR2 and CCR5 Polymorphisms in Tunisian Patients with Atopic Asthma |
title_fullStr |
MCP-1, CCR2 and CCR5 Polymorphisms in Tunisian Patients with Atopic Asthma |
title_full_unstemmed |
MCP-1, CCR2 and CCR5 Polymorphisms in Tunisian Patients with Atopic Asthma |
title_sort |
mcp-1, ccr2 and ccr5 polymorphisms in tunisian patients with atopic asthma |
publisher |
Tehran University of Medical Sciences |
series |
Iranian Journal of Allergy, Asthma and Immunology |
issn |
1735-1502 1735-5249 |
publishDate |
2013-03-01 |
description |
Chemokines and their receptors play an important role in the late inflammatory stage of asthma. In this study, we aimed to investigate polymorphisms of MCP-1 (CCL2), CCR2 and CCR5 which can affect qualitatively and/or quantitatively their production and thus influence both susceptibility and severity of asthma and its clinical and biological features.
MCP-1 (A/G -2518), CCR2 (+/64I), CCR5 (G/A -59029) and CCR5 (∆32)polymorphisms were evaluated by PCR in 107 Tunisian patients with asthma and 169 healthy controls.
No significant association was found between the four investigated polymorphisms and asthma. Nevertheless the haplotype MCP1*AG/CCR2*+/+ was significantly l ess frequent in patients (20.5%) compared to controls (32.5%) (p=0.03; OR=0.54; 95% CI:0.29-0.98). Whereas no difference was observed in CCR2/CCR5 haplotypes between patients and controls. Analysis of polymorphisms with clinical and biological features showed that the concomitant presence of MCP-1*G/CCR2*64I alleles was less frequent in severe forms (4.34%) compared to moderate disease (12%) but the difference was not significant (p=0.27). No association was observed between the four polymorphisms and the presence of atopic rhinitis or atopic conjunctivitis and an elevated rate of serum IgE over 200 IU/ml.
Additional effects of MCP-1 and its receptor CCR2 polymorphisms seem to be involved in disease susceptibility to asthma in Tunisian patients; nevertheless they could be protective against its severe forms.
|
topic |
Asthma Atopy Chemokines MCP-1 Polymorphism |
url |
https://ijaai.tums.ac.ir/index.php/ijaai/article/view/537 |
work_keys_str_mv |
AT tarakdhaouadi mcp1ccr2andccr5polymorphismsintunisianpatientswithatopicasthma AT imensfar mcp1ccr2andccr5polymorphismsintunisianpatientswithatopicasthma AT hajeraounallahskhiri mcp1ccr2andccr5polymorphismsintunisianpatientswithatopicasthma AT salouajendoubiayed mcp1ccr2andccr5polymorphismsintunisianpatientswithatopicasthma AT hendbouacha mcp1ccr2andccr5polymorphismsintunisianpatientswithatopicasthma AT taiebbenabdallah mcp1ccr2andccr5polymorphismsintunisianpatientswithatopicasthma AT yousrgorgi mcp1ccr2andccr5polymorphismsintunisianpatientswithatopicasthma |
_version_ |
1724425093374803968 |