High-Grade Osteosarcoma of the Foot: Presentation, Treatment, Prognostic Factors, and Outcome of 23 Cooperative Osteosarcoma Study Group COSS Patients
Osteosarcoma of the foot is a very rare presentation of a rare tumor entity. In a retrospective analysis, we investigated tumor- and treatment-related variables and outcome of patients registered in the Cooperative Osteosarcoma Study Group (COSS) database between January 1980 and April 2016 who suff...
Main Authors: | , , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2018-01-01
|
Series: | Sarcoma |
Online Access: | http://dx.doi.org/10.1155/2018/1632978 |
id |
doaj-a5fd2a57ddd14a9d88b0cd3a9351561f |
---|---|
record_format |
Article |
spelling |
doaj-a5fd2a57ddd14a9d88b0cd3a9351561f2020-11-25T01:11:49ZengHindawi LimitedSarcoma1357-714X1369-16432018-01-01201810.1155/2018/16329781632978High-Grade Osteosarcoma of the Foot: Presentation, Treatment, Prognostic Factors, and Outcome of 23 Cooperative Osteosarcoma Study Group COSS PatientsAnne J. Schuster0Leo Kager1Peter Reichardt2Daniel Baumhoer3Monika Csóka4Stefanie Hecker-Nolting5Susanna Lang6Sylvie Lorenzen7Regine Mayer-Steinacker8Thekla von Kalle9Matthias Kevric10Mathias Werner11Reinhard Windhager12Thomas Wirth13Stefan S. Bielack14Center for Pediatric, Adolescent and Women's Medicine, Olgahospital, Department of Pediatrics 5 (Oncology, Hematology, Immunology), Klinikum Stuttgart, Stuttgart, GermanySt. Anna Children’s Hospital, Department of Paediatrics, Medical University of Vienna and Children’s Cancer Research Institute (CCRI), Vienna, AustriaDepartment of Interdisciplinary Oncology, HELIOS Klinikum Berlin-Buch, Berlin, GermanyBone Tumour Reference Centre (BTRC), Institute of Pathology, University Hospital of Basel and University of Basel, Basel, Switzerland2nd Department of Pediatrics, Semmelweis University, Budapest, HungaryCenter for Pediatric, Adolescent and Women's Medicine, Olgahospital, Department of Pediatrics 5 (Oncology, Hematology, Immunology), Klinikum Stuttgart, Stuttgart, GermanyDepartment of Pathology, Vienna General Hospital, Medical University of Vienna, Vienna, AustriaDepartment of Hematology and Oncology, Klinikum rechts der Isar Technische Universität München, Munich, GermanyDepartment of Internal Medicine III, University of Ulm, Ulm, GermanyCenter for Pediatric, Adolescent and Women’s Medicine, Olgahospital, Department of Pediatric Radiology, Klinikum Stuttgart, Stuttgart, GermanyCenter for Pediatric, Adolescent and Women's Medicine, Olgahospital, Department of Pediatrics 5 (Oncology, Hematology, Immunology), Klinikum Stuttgart, Stuttgart, GermanyDepartment of Interdisciplinary Oncology, HELIOS Klinikum Berlin-Buch, Berlin, GermanyDepartment of Orthopaedics, Medical University of Vienna, Vienna, AustriaCenter for Pediatric, Adolescent and Women’s Medicine, Olgahospital, Department of Pediatrics, Division of Pediatric Orthopedics, Klinikum Stuttgart, Stuttgart, GermanyCenter for Pediatric, Adolescent and Women's Medicine, Olgahospital, Department of Pediatrics 5 (Oncology, Hematology, Immunology), Klinikum Stuttgart, Stuttgart, GermanyOsteosarcoma of the foot is a very rare presentation of a rare tumor entity. In a retrospective analysis, we investigated tumor- and treatment-related variables and outcome of patients registered in the Cooperative Osteosarcoma Study Group (COSS) database between January 1980 and April 2016 who suffered from primary high-grade osteosarcoma of the foot. Among the 23 eligible patients, median age was 32 years (range: 6–58 years), 10 were female, and 13 were male. The tarsus was the most commonly affected site (n=16). Three patients had primary metastases. All patients were operated: 5 underwent primary surgery and 18 received surgery following preoperative chemotherapy. In 21 of the 23 patients, complete surgical remission was achieved. In 4 of 17 patients, a poor response to neoadjuvant chemotherapy was observed in the resected primary tumors. Median follow-up was 4.2 years (range: 0.4–18.5). At the last follow-up, 15 of the 23 patients were alive and 8 had died. Five-year overall and event-free survival estimates were 64% (standard error (SE) 12%) and 54% (SE 13%), which is similar to that observed for osteosarcoma in general. Event-free and overall survival correlated with primary metastatic status and completeness of surgery. Our findings show that high-grade osteosarcoma in the foot has a similar outcome as osteosarcoma of other sites.http://dx.doi.org/10.1155/2018/1632978 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Anne J. Schuster Leo Kager Peter Reichardt Daniel Baumhoer Monika Csóka Stefanie Hecker-Nolting Susanna Lang Sylvie Lorenzen Regine Mayer-Steinacker Thekla von Kalle Matthias Kevric Mathias Werner Reinhard Windhager Thomas Wirth Stefan S. Bielack |
spellingShingle |
Anne J. Schuster Leo Kager Peter Reichardt Daniel Baumhoer Monika Csóka Stefanie Hecker-Nolting Susanna Lang Sylvie Lorenzen Regine Mayer-Steinacker Thekla von Kalle Matthias Kevric Mathias Werner Reinhard Windhager Thomas Wirth Stefan S. Bielack High-Grade Osteosarcoma of the Foot: Presentation, Treatment, Prognostic Factors, and Outcome of 23 Cooperative Osteosarcoma Study Group COSS Patients Sarcoma |
author_facet |
Anne J. Schuster Leo Kager Peter Reichardt Daniel Baumhoer Monika Csóka Stefanie Hecker-Nolting Susanna Lang Sylvie Lorenzen Regine Mayer-Steinacker Thekla von Kalle Matthias Kevric Mathias Werner Reinhard Windhager Thomas Wirth Stefan S. Bielack |
author_sort |
Anne J. Schuster |
title |
High-Grade Osteosarcoma of the Foot: Presentation, Treatment, Prognostic Factors, and Outcome of 23 Cooperative Osteosarcoma Study Group COSS Patients |
title_short |
High-Grade Osteosarcoma of the Foot: Presentation, Treatment, Prognostic Factors, and Outcome of 23 Cooperative Osteosarcoma Study Group COSS Patients |
title_full |
High-Grade Osteosarcoma of the Foot: Presentation, Treatment, Prognostic Factors, and Outcome of 23 Cooperative Osteosarcoma Study Group COSS Patients |
title_fullStr |
High-Grade Osteosarcoma of the Foot: Presentation, Treatment, Prognostic Factors, and Outcome of 23 Cooperative Osteosarcoma Study Group COSS Patients |
title_full_unstemmed |
High-Grade Osteosarcoma of the Foot: Presentation, Treatment, Prognostic Factors, and Outcome of 23 Cooperative Osteosarcoma Study Group COSS Patients |
title_sort |
high-grade osteosarcoma of the foot: presentation, treatment, prognostic factors, and outcome of 23 cooperative osteosarcoma study group coss patients |
publisher |
Hindawi Limited |
series |
Sarcoma |
issn |
1357-714X 1369-1643 |
publishDate |
2018-01-01 |
description |
Osteosarcoma of the foot is a very rare presentation of a rare tumor entity. In a retrospective analysis, we investigated tumor- and treatment-related variables and outcome of patients registered in the Cooperative Osteosarcoma Study Group (COSS) database between January 1980 and April 2016 who suffered from primary high-grade osteosarcoma of the foot. Among the 23 eligible patients, median age was 32 years (range: 6–58 years), 10 were female, and 13 were male. The tarsus was the most commonly affected site (n=16). Three patients had primary metastases. All patients were operated: 5 underwent primary surgery and 18 received surgery following preoperative chemotherapy. In 21 of the 23 patients, complete surgical remission was achieved. In 4 of 17 patients, a poor response to neoadjuvant chemotherapy was observed in the resected primary tumors. Median follow-up was 4.2 years (range: 0.4–18.5). At the last follow-up, 15 of the 23 patients were alive and 8 had died. Five-year overall and event-free survival estimates were 64% (standard error (SE) 12%) and 54% (SE 13%), which is similar to that observed for osteosarcoma in general. Event-free and overall survival correlated with primary metastatic status and completeness of surgery. Our findings show that high-grade osteosarcoma in the foot has a similar outcome as osteosarcoma of other sites. |
url |
http://dx.doi.org/10.1155/2018/1632978 |
work_keys_str_mv |
AT annejschuster highgradeosteosarcomaofthefootpresentationtreatmentprognosticfactorsandoutcomeof23cooperativeosteosarcomastudygroupcosspatients AT leokager highgradeosteosarcomaofthefootpresentationtreatmentprognosticfactorsandoutcomeof23cooperativeosteosarcomastudygroupcosspatients AT peterreichardt highgradeosteosarcomaofthefootpresentationtreatmentprognosticfactorsandoutcomeof23cooperativeosteosarcomastudygroupcosspatients AT danielbaumhoer highgradeosteosarcomaofthefootpresentationtreatmentprognosticfactorsandoutcomeof23cooperativeosteosarcomastudygroupcosspatients AT monikacsoka highgradeosteosarcomaofthefootpresentationtreatmentprognosticfactorsandoutcomeof23cooperativeosteosarcomastudygroupcosspatients AT stefanieheckernolting highgradeosteosarcomaofthefootpresentationtreatmentprognosticfactorsandoutcomeof23cooperativeosteosarcomastudygroupcosspatients AT susannalang highgradeosteosarcomaofthefootpresentationtreatmentprognosticfactorsandoutcomeof23cooperativeosteosarcomastudygroupcosspatients AT sylvielorenzen highgradeosteosarcomaofthefootpresentationtreatmentprognosticfactorsandoutcomeof23cooperativeosteosarcomastudygroupcosspatients AT reginemayersteinacker highgradeosteosarcomaofthefootpresentationtreatmentprognosticfactorsandoutcomeof23cooperativeosteosarcomastudygroupcosspatients AT theklavonkalle highgradeosteosarcomaofthefootpresentationtreatmentprognosticfactorsandoutcomeof23cooperativeosteosarcomastudygroupcosspatients AT matthiaskevric highgradeosteosarcomaofthefootpresentationtreatmentprognosticfactorsandoutcomeof23cooperativeosteosarcomastudygroupcosspatients AT mathiaswerner highgradeosteosarcomaofthefootpresentationtreatmentprognosticfactorsandoutcomeof23cooperativeosteosarcomastudygroupcosspatients AT reinhardwindhager highgradeosteosarcomaofthefootpresentationtreatmentprognosticfactorsandoutcomeof23cooperativeosteosarcomastudygroupcosspatients AT thomaswirth highgradeosteosarcomaofthefootpresentationtreatmentprognosticfactorsandoutcomeof23cooperativeosteosarcomastudygroupcosspatients AT stefansbielack highgradeosteosarcomaofthefootpresentationtreatmentprognosticfactorsandoutcomeof23cooperativeosteosarcomastudygroupcosspatients |
_version_ |
1725169596850241536 |