Anti-HIV-1 ADCC and HIV-1 Env Can Be Partners in Reducing Latent HIV Reservoir

Anti-HIV-1 ADCC and HIV-1 Env Can Be Partners in Reducing Latent HIV Reservoir

BackgroundPersistence of HIV reservoir even in suppressive ART is the key obstacle in HIV-1 cure. We evaluated the ability of HIV-1 C Env to reactivate the latently infected resting memory CD4 cells and the ability of polyclonal HIV antibodies mediating ADCC to lyse the reactivated targets.Methodolo...

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Bibliographic Details
Main Authors: Poonam Suryawanshi, Rajani Bagul, Ashwini Shete, Madhuri Thakar
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
anti-HIV antibodies
latent HIV
ADCC
HIV Env
HIV
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.663919/full

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