Lower Serum Levels of Uric Acid in Uterine Fi¬broids and Fibro-cystic Breast Disease Patients in Dongying City, China

• Main Authors: Qicai CHEN, Juan XIAO, Pengpeng ZHANG, Lili CHEN, Xiaoxiao CHEN, Shumei WANG
• Format: Article
• Language: English
• Published: Tehran University of Medical Sciences 2016-05-01
• Series: Iranian Journal of Public Health
• Online Access: http://ijph.tums.ac.ir/index.php/ijph/article/view/6795

<p><strong>Background:</strong> Increasing serum levels of uric acid (SUA) after menopause in women brought up a hypothesis that estrogenic effect may protectively regulate SUA. Estrogenic effect is a major etiology of uterine fibroids and fibrocystic breast disease. The study aimed<strong> </strong>to<strong> </strong>explore SUA among patients suffering from these diseases to enhance the hypothesis.<strong> </strong></p><p><strong>Methods</strong><strong>: </strong>Overall<strong>, </strong>1349 female participants were selected into three cases: CaseⅠhaving uterine fibroids (n=568), CaseⅡ having fibrocycstic breast disease (n=608) and CaseⅢ having uterine fibroids combining with fibrocycstic breast disease (n=173); 4206 participants without these diseases were selected as controls. Based on health check-up data from 2011 to 2012, in Dongying Shengli Oilfield Central Hospital, a cross-sectional study was conducted to examine the difference in SUA between the case and control. We adjusted covariates by generalized linear regression mode.</p><p><strong>Results</strong><strong>:</strong> From 19 to 44 yr, SUA of CaseⅠ to CaseⅢ were lower than controls by 8.46 umol/L (<em>P</em>=0.011), 5.88umol/L (<em>P</em>=0.014) and 9.39 umol/L (<em>P</em>=0.059), respectively. From 45-54 yr, no significant differences were between three cases and controls. In CaseⅠand its control: from 54-59 yr, differences were not significant; from 60 to 72 yr, SUA in CaseⅠwas lower than the control by 32.02umol/L (<em>P</em>=0.003). <strong></strong></p><p><strong>Conclusion</strong><strong>:</strong> Participants of uterine fibroids and fibrocystic breast disease had a lower SUA except the stage of menopause, which indirectly supported that estrogenic effect, may protectively decrease SUA.</p><p> </p><p><strong>Keywords:</strong> Uric acid, Estrogenic effect, Leiomyoma and fibrocyst, Breast disease</p><p><strong> </strong></p>