Lower Serum Levels of Uric Acid in Uterine Fi¬broids and Fibro-cystic Breast Disease Patients in Dongying City, China
<p><strong>Background:</strong> Increasing serum levels of uric acid (SUA) after menopause in women brought up a hypothesis that estrogenic effect may protectively regulate SUA. Estrogenic effect is a major etiology of uterine fibroids and fibrocystic breast disease. The study aime...
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Tehran University of Medical Sciences
2016-05-01
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Series: | Iranian Journal of Public Health |
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doaj-a60d8c42d4a345dca1929ec20dfe72282020-12-02T07:26:58ZengTehran University of Medical SciencesIranian Journal of Public Health2251-60852251-60932016-05-014555966054901Lower Serum Levels of Uric Acid in Uterine Fi¬broids and Fibro-cystic Breast Disease Patients in Dongying City, ChinaQicai CHENJuan XIAOPengpeng ZHANGLili CHENXiaoxiao CHENShumei WANG<p><strong>Background:</strong> Increasing serum levels of uric acid (SUA) after menopause in women brought up a hypothesis that estrogenic effect may protectively regulate SUA. Estrogenic effect is a major etiology of uterine fibroids and fibrocystic breast disease. The study aimed<strong> </strong>to<strong> </strong>explore SUA among patients suffering from these diseases to enhance the hypothesis.<strong> </strong></p><p><strong>Methods</strong><strong>: </strong>Overall<strong>, </strong>1349 female participants were selected into three cases: CaseⅠhaving uterine fibroids (n=568), CaseⅡ having fibrocycstic breast disease (n=608) and CaseⅢ having uterine fibroids combining with fibrocycstic breast disease (n=173); 4206 participants without these diseases were selected as controls. Based on health check-up data from 2011 to 2012, in Dongying Shengli Oilfield Central Hospital, a cross-sectional study was conducted to examine the difference in SUA between the case and control. We adjusted covariates by generalized linear regression mode.</p><p><strong>Results</strong><strong>:</strong> From 19 to 44 yr, SUA of CaseⅠ to CaseⅢ were lower than controls by 8.46 umol/L (<em>P</em>=0.011), 5.88umol/L (<em>P</em>=0.014) and 9.39 umol/L (<em>P</em>=0.059), respectively. From 45-54 yr, no significant differences were between three cases and controls. In CaseⅠand its control: from 54-59 yr, differences were not significant; from 60 to 72 yr, SUA in CaseⅠwas lower than the control by 32.02umol/L (<em>P</em>=0.003). <strong></strong></p><p><strong>Conclusion</strong><strong>:</strong> Participants of uterine fibroids and fibrocystic breast disease had a lower SUA except the stage of menopause, which indirectly supported that estrogenic effect, may protectively decrease SUA.</p><p> </p><p><strong>Keywords:</strong> Uric acid, Estrogenic effect, Leiomyoma and fibrocyst, Breast disease</p><p><strong> </strong></p>http://ijph.tums.ac.ir/index.php/ijph/article/view/6795 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Qicai CHEN Juan XIAO Pengpeng ZHANG Lili CHEN Xiaoxiao CHEN Shumei WANG |
spellingShingle |
Qicai CHEN Juan XIAO Pengpeng ZHANG Lili CHEN Xiaoxiao CHEN Shumei WANG Lower Serum Levels of Uric Acid in Uterine Fi¬broids and Fibro-cystic Breast Disease Patients in Dongying City, China Iranian Journal of Public Health |
author_facet |
Qicai CHEN Juan XIAO Pengpeng ZHANG Lili CHEN Xiaoxiao CHEN Shumei WANG |
author_sort |
Qicai CHEN |
title |
Lower Serum Levels of Uric Acid in Uterine Fi¬broids and Fibro-cystic Breast Disease Patients in Dongying City, China |
title_short |
Lower Serum Levels of Uric Acid in Uterine Fi¬broids and Fibro-cystic Breast Disease Patients in Dongying City, China |
title_full |
Lower Serum Levels of Uric Acid in Uterine Fi¬broids and Fibro-cystic Breast Disease Patients in Dongying City, China |
title_fullStr |
Lower Serum Levels of Uric Acid in Uterine Fi¬broids and Fibro-cystic Breast Disease Patients in Dongying City, China |
title_full_unstemmed |
Lower Serum Levels of Uric Acid in Uterine Fi¬broids and Fibro-cystic Breast Disease Patients in Dongying City, China |
title_sort |
lower serum levels of uric acid in uterine fi¬broids and fibro-cystic breast disease patients in dongying city, china |
publisher |
Tehran University of Medical Sciences |
series |
Iranian Journal of Public Health |
issn |
2251-6085 2251-6093 |
publishDate |
2016-05-01 |
description |
<p><strong>Background:</strong> Increasing serum levels of uric acid (SUA) after menopause in women brought up a hypothesis that estrogenic effect may protectively regulate SUA. Estrogenic effect is a major etiology of uterine fibroids and fibrocystic breast disease. The study aimed<strong> </strong>to<strong> </strong>explore SUA among patients suffering from these diseases to enhance the hypothesis.<strong> </strong></p><p><strong>Methods</strong><strong>: </strong>Overall<strong>, </strong>1349 female participants were selected into three cases: CaseⅠhaving uterine fibroids (n=568), CaseⅡ having fibrocycstic breast disease (n=608) and CaseⅢ having uterine fibroids combining with fibrocycstic breast disease (n=173); 4206 participants without these diseases were selected as controls. Based on health check-up data from 2011 to 2012, in Dongying Shengli Oilfield Central Hospital, a cross-sectional study was conducted to examine the difference in SUA between the case and control. We adjusted covariates by generalized linear regression mode.</p><p><strong>Results</strong><strong>:</strong> From 19 to 44 yr, SUA of CaseⅠ to CaseⅢ were lower than controls by 8.46 umol/L (<em>P</em>=0.011), 5.88umol/L (<em>P</em>=0.014) and 9.39 umol/L (<em>P</em>=0.059), respectively. From 45-54 yr, no significant differences were between three cases and controls. In CaseⅠand its control: from 54-59 yr, differences were not significant; from 60 to 72 yr, SUA in CaseⅠwas lower than the control by 32.02umol/L (<em>P</em>=0.003). <strong></strong></p><p><strong>Conclusion</strong><strong>:</strong> Participants of uterine fibroids and fibrocystic breast disease had a lower SUA except the stage of menopause, which indirectly supported that estrogenic effect, may protectively decrease SUA.</p><p> </p><p><strong>Keywords:</strong> Uric acid, Estrogenic effect, Leiomyoma and fibrocyst, Breast disease</p><p><strong> </strong></p> |
url |
http://ijph.tums.ac.ir/index.php/ijph/article/view/6795 |
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