Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood
To comprehend the genetic regulatory mechanisms underlying brain-related traits in humans, Qi et al. estimate the correlation of expression and DNA methylation QTL effects in cis between blood and brain and show that using blood eQTL/mQTL data of large sample size can increase power in gene discove...
Main Authors: | , , , , , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2018-06-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-018-04558-1 |
id |
doaj-a6120d781df04a21806a6667b60aa876 |
---|---|
record_format |
Article |
spelling |
doaj-a6120d781df04a21806a6667b60aa8762021-05-11T10:18:23ZengNature Publishing GroupNature Communications2041-17232018-06-019111210.1038/s41467-018-04558-1Identifying gene targets for brain-related traits using transcriptomic and methylomic data from bloodTing Qi0Yang Wu1Jian Zeng2Futao Zhang3Angli Xue4Longda Jiang5Zhihong Zhu6Kathryn Kemper7Loic Yengo8Zhili Zheng9eQTLGen ConsortiumRiccardo E. Marioni10Grant W. Montgomery11Ian J. Deary12Naomi R. Wray13Peter M. Visscher14Allan F. McRae15Jian Yang16Institute for Molecular Bioscience, The University of QueenslandInstitute for Molecular Bioscience, The University of QueenslandInstitute for Molecular Bioscience, The University of QueenslandInstitute for Molecular Bioscience, The University of QueenslandInstitute for Molecular Bioscience, The University of QueenslandInstitute for Molecular Bioscience, The University of QueenslandInstitute for Molecular Bioscience, The University of QueenslandInstitute for Molecular Bioscience, The University of QueenslandInstitute for Molecular Bioscience, The University of QueenslandInstitute for Molecular Bioscience, The University of QueenslandMedical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of EdinburghInstitute for Molecular Bioscience, The University of QueenslandDepartment of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, University of EdinburghInstitute for Molecular Bioscience, The University of QueenslandInstitute for Molecular Bioscience, The University of QueenslandInstitute for Molecular Bioscience, The University of QueenslandInstitute for Molecular Bioscience, The University of QueenslandTo comprehend the genetic regulatory mechanisms underlying brain-related traits in humans, Qi et al. estimate the correlation of expression and DNA methylation QTL effects in cis between blood and brain and show that using blood eQTL/mQTL data of large sample size can increase power in gene discovery for brain-related traits and diseases.https://doi.org/10.1038/s41467-018-04558-1 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ting Qi Yang Wu Jian Zeng Futao Zhang Angli Xue Longda Jiang Zhihong Zhu Kathryn Kemper Loic Yengo Zhili Zheng eQTLGen Consortium Riccardo E. Marioni Grant W. Montgomery Ian J. Deary Naomi R. Wray Peter M. Visscher Allan F. McRae Jian Yang |
spellingShingle |
Ting Qi Yang Wu Jian Zeng Futao Zhang Angli Xue Longda Jiang Zhihong Zhu Kathryn Kemper Loic Yengo Zhili Zheng eQTLGen Consortium Riccardo E. Marioni Grant W. Montgomery Ian J. Deary Naomi R. Wray Peter M. Visscher Allan F. McRae Jian Yang Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood Nature Communications |
author_facet |
Ting Qi Yang Wu Jian Zeng Futao Zhang Angli Xue Longda Jiang Zhihong Zhu Kathryn Kemper Loic Yengo Zhili Zheng eQTLGen Consortium Riccardo E. Marioni Grant W. Montgomery Ian J. Deary Naomi R. Wray Peter M. Visscher Allan F. McRae Jian Yang |
author_sort |
Ting Qi |
title |
Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood |
title_short |
Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood |
title_full |
Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood |
title_fullStr |
Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood |
title_full_unstemmed |
Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood |
title_sort |
identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2018-06-01 |
description |
To comprehend the genetic regulatory mechanisms underlying brain-related traits in humans, Qi et al. estimate the correlation of expression and DNA methylation QTL effects in cis between blood and brain and show that using blood eQTL/mQTL data of large sample size can increase power in gene discovery for brain-related traits and diseases. |
url |
https://doi.org/10.1038/s41467-018-04558-1 |
work_keys_str_mv |
AT tingqi identifyinggenetargetsforbrainrelatedtraitsusingtranscriptomicandmethylomicdatafromblood AT yangwu identifyinggenetargetsforbrainrelatedtraitsusingtranscriptomicandmethylomicdatafromblood AT jianzeng identifyinggenetargetsforbrainrelatedtraitsusingtranscriptomicandmethylomicdatafromblood AT futaozhang identifyinggenetargetsforbrainrelatedtraitsusingtranscriptomicandmethylomicdatafromblood AT anglixue identifyinggenetargetsforbrainrelatedtraitsusingtranscriptomicandmethylomicdatafromblood AT longdajiang identifyinggenetargetsforbrainrelatedtraitsusingtranscriptomicandmethylomicdatafromblood AT zhihongzhu identifyinggenetargetsforbrainrelatedtraitsusingtranscriptomicandmethylomicdatafromblood AT kathrynkemper identifyinggenetargetsforbrainrelatedtraitsusingtranscriptomicandmethylomicdatafromblood AT loicyengo identifyinggenetargetsforbrainrelatedtraitsusingtranscriptomicandmethylomicdatafromblood AT zhilizheng identifyinggenetargetsforbrainrelatedtraitsusingtranscriptomicandmethylomicdatafromblood AT eqtlgenconsortium identifyinggenetargetsforbrainrelatedtraitsusingtranscriptomicandmethylomicdatafromblood AT riccardoemarioni identifyinggenetargetsforbrainrelatedtraitsusingtranscriptomicandmethylomicdatafromblood AT grantwmontgomery identifyinggenetargetsforbrainrelatedtraitsusingtranscriptomicandmethylomicdatafromblood AT ianjdeary identifyinggenetargetsforbrainrelatedtraitsusingtranscriptomicandmethylomicdatafromblood AT naomirwray identifyinggenetargetsforbrainrelatedtraitsusingtranscriptomicandmethylomicdatafromblood AT petermvisscher identifyinggenetargetsforbrainrelatedtraitsusingtranscriptomicandmethylomicdatafromblood AT allanfmcrae identifyinggenetargetsforbrainrelatedtraitsusingtranscriptomicandmethylomicdatafromblood AT jianyang identifyinggenetargetsforbrainrelatedtraitsusingtranscriptomicandmethylomicdatafromblood |
_version_ |
1721448420011409408 |