Importance of Proximal Angle in Generation of Abnormal Plaque at Coronary Bifurcation Lesions
BACKGROUND: Changing of linear blood flow to turbulence at branching points predisposes to development of obstructive coronary lesions. We hypothesize that in addition to bifurcation angle (BA), proximal (PA) and third angle (TA) of branching site are important in generating more vertices of blood f...
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doaj-a61d753ec1d249e38d3884cfd36620d62020-12-02T17:52:46ZengThieme Medical and Scientific Publishers Pvt. Ltd.Indian Journal of Cardiovascular Disease in Women2455-78542016-03-01010100801310.1055/s-0038-1656469Importance of Proximal Angle in Generation of Abnormal Plaque at Coronary Bifurcation LesionsK. Deepti0M S Aditya1Senior resident, Department of Cardiology, NIMS, IndiaAssistant Professor, Department of Cardiology, NIMS, IndiaBACKGROUND: Changing of linear blood flow to turbulence at branching points predisposes to development of obstructive coronary lesions. We hypothesize that in addition to bifurcation angle (BA), proximal (PA) and third angle (TA) of branching site are important in generating more vertices of blood flow. METHODS: 65 normal and 36 significantly diseased LAD – D1, 72 normal and 27 significantly diseased LCX – OM, 73 normal and 16 significantly diseased RCA – PDA – PLV and 34 normal and 14 significantly diseased LMCA – LAD – LCX bifurcations were analyzed with QCA. RESULTS: In LAD – D1 normal vs. significantly diseased bifurcations BA and PA were 78.2±13.2 vs. 65.1±11.3 (p <0.000) and 122.7±13.8 vs. 131.6.36±12.5 (p <0.001) respectively. In LCX – OM normal vs. significantly diseased bifurcations BA and PA were 76.8±13.6 vs. 60.7±13.8 (p=0.000) and 125.1±13.5 vs. 137.8±12.8 (p <0.000) respectively. In RCA - PDA – PLV normal vs. significantly diseased bifurcations BA, PA and TA were 91.1±13.8 vs. 71.5±15.9 (p 0.004), 113.0±14.1 vs. 128.4±20.2 (p=0.000), 118.2±21.7 vs. 133.8±12.4 (p=0.007) respectively. In LMCA –LAD – LCX normal vs. significantly diseased bifurcations BA, PA and TA were 84.0±39.1 vs. 73.0±17.6 (p >0. 32), 123.2±26.3 vs. 115.3±30.4 (p > 0.38), 130.3±27.3 vs. 137.5±33.5 (p >0.45) respectively. There was a significant difference but no correlation between the angles in normal and diseased bifurcation segment. We derived logistic regression equations for predicting the disease in different coronary bifurcations. CONCLUSION: In LAD - D1, LCX – OM and RCA – PDA – PLV bifurcations lesser the BA, greater the PA, were more likely to develop significant lesion, which was not true in LMCA – LAD – LCX bifurcation.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1656469bifurcation angleproximal anglecoronary artery disease |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
K. Deepti M S Aditya |
spellingShingle |
K. Deepti M S Aditya Importance of Proximal Angle in Generation of Abnormal Plaque at Coronary Bifurcation Lesions Indian Journal of Cardiovascular Disease in Women bifurcation angle proximal angle coronary artery disease |
author_facet |
K. Deepti M S Aditya |
author_sort |
K. Deepti |
title |
Importance of Proximal Angle in Generation of Abnormal Plaque at Coronary Bifurcation Lesions |
title_short |
Importance of Proximal Angle in Generation of Abnormal Plaque at Coronary Bifurcation Lesions |
title_full |
Importance of Proximal Angle in Generation of Abnormal Plaque at Coronary Bifurcation Lesions |
title_fullStr |
Importance of Proximal Angle in Generation of Abnormal Plaque at Coronary Bifurcation Lesions |
title_full_unstemmed |
Importance of Proximal Angle in Generation of Abnormal Plaque at Coronary Bifurcation Lesions |
title_sort |
importance of proximal angle in generation of abnormal plaque at coronary bifurcation lesions |
publisher |
Thieme Medical and Scientific Publishers Pvt. Ltd. |
series |
Indian Journal of Cardiovascular Disease in Women |
issn |
2455-7854 |
publishDate |
2016-03-01 |
description |
BACKGROUND: Changing of linear blood flow to turbulence at branching points predisposes to development of obstructive coronary lesions. We hypothesize that in addition to bifurcation angle (BA), proximal (PA) and third angle (TA) of branching site are important in generating more vertices of blood flow. METHODS: 65 normal and 36 significantly diseased LAD – D1, 72 normal and 27 significantly diseased LCX – OM, 73 normal and 16 significantly diseased RCA – PDA – PLV and 34 normal and 14 significantly diseased LMCA – LAD – LCX bifurcations were analyzed with QCA. RESULTS: In LAD – D1 normal vs. significantly diseased bifurcations BA and PA were 78.2±13.2 vs. 65.1±11.3 (p <0.000) and 122.7±13.8 vs. 131.6.36±12.5 (p <0.001) respectively. In LCX – OM normal vs. significantly diseased bifurcations BA and PA were 76.8±13.6 vs. 60.7±13.8 (p=0.000) and 125.1±13.5 vs. 137.8±12.8 (p <0.000) respectively. In RCA - PDA – PLV normal vs. significantly diseased bifurcations BA, PA and TA were 91.1±13.8 vs. 71.5±15.9 (p 0.004), 113.0±14.1 vs. 128.4±20.2 (p=0.000), 118.2±21.7 vs. 133.8±12.4 (p=0.007) respectively. In LMCA –LAD – LCX normal vs. significantly diseased bifurcations BA, PA and TA were 84.0±39.1 vs. 73.0±17.6 (p >0. 32), 123.2±26.3 vs. 115.3±30.4 (p > 0.38), 130.3±27.3 vs. 137.5±33.5 (p >0.45) respectively. There was a significant difference but no correlation between the angles in normal and diseased bifurcation segment. We derived logistic regression equations for predicting the disease in different coronary bifurcations. CONCLUSION: In LAD - D1, LCX – OM and RCA – PDA – PLV bifurcations lesser the BA, greater the PA, were more likely to develop significant lesion, which was not true in LMCA – LAD – LCX bifurcation. |
topic |
bifurcation angle proximal angle coronary artery disease |
url |
http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1656469 |
work_keys_str_mv |
AT kdeepti importanceofproximalangleingenerationofabnormalplaqueatcoronarybifurcationlesions AT msaditya importanceofproximalangleingenerationofabnormalplaqueatcoronarybifurcationlesions |
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