Synthesis of a New ent-Cyclozonarone Angular Analog, and Comparison of Its Cytotoxicity and Apoptotic Effects with ent-Cyclozonarone

Synthesis of a New ent-Cyclozonarone Angular Analog, and Comparison of Its Cytotoxicity and Apoptotic Effects with ent-Cyclozonarone

The synthesis of a newangular analog 11 of cyclozonarone was achieved via Diels-Alder reaction between a sesquiterpene-1,3-diene and 1,4-benzoquinone. The cytotoxic activity of ent-cyclozonarone [(+)-10] and the angular (−)-cyclozonarone analog 11 has been determined in three human cancer cell lines...

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Bibliographic Details
Main Authors: Mauricio Cuellar Fritis, Valentina Ulloa Valdivia, Joan Villena García, Cristóbal Carrasco Rojas, Luis Espinoza Catalán, Cristian Salas Sánchez, Iván Montenegro Venegas, Natalia Quiñones Sobarzo
Format: Article
Language:English
Published: MDPI AG 2013-05-01
Series:Molecules
Subjects:
sesquiterpenequinone
ent-cyclozonarone
cancer cells
cytotoxicity
apoptosis
caspase 3
mitochondrial membrane permeability
Online Access:http://www.mdpi.com/1420-3049/18/5/5517

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