Comparative effectiveness of palliative chemotherapy versus neoadjuvant chemotherapy followed by radical cystectomy versus cystectomy followed by adjuvant chemotherapy versus cystectomy for regional node‐positive bladder cancer: A retrospective analysis: KCSG GU 17‐03
Abstract The regional lymph node‐positive bladder cancer was classified as stage IV in the AJCC 7th edition but was changed to stage IIIB in the 8th edition, revised in 2018. Among the various studies involving immune checkpoint inhibitors, groups that had only lymph node metastasis showed better ou...
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Wiley
2019-09-01
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Series: | Cancer Medicine |
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Online Access: | https://doi.org/10.1002/cam4.2446 |
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Article |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Woo Kyun Bae Hyo Jin Lee Se Hoon Park Jung Hoon Kim Hee Jun Kim Chi Hoon Maeng Inkeun Park Byeong Seok Sohn Jung A. Kim Kyung Hee Lee Do Hyoung Lim Hyun Chang Sung Min Kim Ho Young Kim Hunho Song Seungtaek Lim Jae Ho Byun Hyun Ae Jung |
spellingShingle |
Woo Kyun Bae Hyo Jin Lee Se Hoon Park Jung Hoon Kim Hee Jun Kim Chi Hoon Maeng Inkeun Park Byeong Seok Sohn Jung A. Kim Kyung Hee Lee Do Hyoung Lim Hyun Chang Sung Min Kim Ho Young Kim Hunho Song Seungtaek Lim Jae Ho Byun Hyun Ae Jung Comparative effectiveness of palliative chemotherapy versus neoadjuvant chemotherapy followed by radical cystectomy versus cystectomy followed by adjuvant chemotherapy versus cystectomy for regional node‐positive bladder cancer: A retrospective analysis: KCSG GU 17‐03 Cancer Medicine bladder cancer chemotherapy lymph node radical cystectomy |
author_facet |
Woo Kyun Bae Hyo Jin Lee Se Hoon Park Jung Hoon Kim Hee Jun Kim Chi Hoon Maeng Inkeun Park Byeong Seok Sohn Jung A. Kim Kyung Hee Lee Do Hyoung Lim Hyun Chang Sung Min Kim Ho Young Kim Hunho Song Seungtaek Lim Jae Ho Byun Hyun Ae Jung |
author_sort |
Woo Kyun Bae |
title |
Comparative effectiveness of palliative chemotherapy versus neoadjuvant chemotherapy followed by radical cystectomy versus cystectomy followed by adjuvant chemotherapy versus cystectomy for regional node‐positive bladder cancer: A retrospective analysis: KCSG GU 17‐03 |
title_short |
Comparative effectiveness of palliative chemotherapy versus neoadjuvant chemotherapy followed by radical cystectomy versus cystectomy followed by adjuvant chemotherapy versus cystectomy for regional node‐positive bladder cancer: A retrospective analysis: KCSG GU 17‐03 |
title_full |
Comparative effectiveness of palliative chemotherapy versus neoadjuvant chemotherapy followed by radical cystectomy versus cystectomy followed by adjuvant chemotherapy versus cystectomy for regional node‐positive bladder cancer: A retrospective analysis: KCSG GU 17‐03 |
title_fullStr |
Comparative effectiveness of palliative chemotherapy versus neoadjuvant chemotherapy followed by radical cystectomy versus cystectomy followed by adjuvant chemotherapy versus cystectomy for regional node‐positive bladder cancer: A retrospective analysis: KCSG GU 17‐03 |
title_full_unstemmed |
Comparative effectiveness of palliative chemotherapy versus neoadjuvant chemotherapy followed by radical cystectomy versus cystectomy followed by adjuvant chemotherapy versus cystectomy for regional node‐positive bladder cancer: A retrospective analysis: KCSG GU 17‐03 |
title_sort |
comparative effectiveness of palliative chemotherapy versus neoadjuvant chemotherapy followed by radical cystectomy versus cystectomy followed by adjuvant chemotherapy versus cystectomy for regional node‐positive bladder cancer: a retrospective analysis: kcsg gu 17‐03 |
publisher |
Wiley |
series |
Cancer Medicine |
issn |
2045-7634 |
publishDate |
2019-09-01 |
description |
Abstract The regional lymph node‐positive bladder cancer was classified as stage IV in the AJCC 7th edition but was changed to stage IIIB in the 8th edition, revised in 2018. Among the various studies involving immune checkpoint inhibitors, groups that had only lymph node metastasis showed better outcomes than those with distant metastasis. Therefore, it is necessary to rethink the treatment strategy for lymph node‐positive bladder cancer. The aim of this study was to compare the treatment outcomes of chemotherapy, surgery, and combination therapy in patients with lymph node‐positive bladder cancer. From 1 January 2010 to 31 December 2015, patients with bladder cancer presenting local lymph node metastasis at the time of diagnosis were treated with a single treatment strategy, with either radical cystectomy or chemotherapy or with a combined strategy using both. Treatment outcomes were retrospectively analyzed on the basis of clinical indices and survival time. Out of 230 patients with bladder cancer, 44 (19.1%) were treated with palliative chemotherapy, 30 (13.0%) with neoadjuvant chemotherapy followed by cystectomy, 129 (56.1%) with cystectomy followed by adjuvant chemotherapy, and 27 (11.7%) with cystectomy alone. Median survival among all groups was 30.4 months. For each group, median overall survival was 19.3, 49.1, 42.6, and 11.2 months, respectively. This study represents an advancement in understanding the impact of clinical treatment patterns of lymph node‐positive bladder cancer through comparison of survival data of patients treated with different therapeutic strategies. Combined treatment resulted in better outcomes than did single treatments. |
topic |
bladder cancer chemotherapy lymph node radical cystectomy |
url |
https://doi.org/10.1002/cam4.2446 |
work_keys_str_mv |
AT wookyunbae comparativeeffectivenessofpalliativechemotherapyversusneoadjuvantchemotherapyfollowedbyradicalcystectomyversuscystectomyfollowedbyadjuvantchemotherapyversuscystectomyforregionalnodepositivebladdercanceraretrospectiveanalysiskcsggu1703 AT hyojinlee comparativeeffectivenessofpalliativechemotherapyversusneoadjuvantchemotherapyfollowedbyradicalcystectomyversuscystectomyfollowedbyadjuvantchemotherapyversuscystectomyforregionalnodepositivebladdercanceraretrospectiveanalysiskcsggu1703 AT sehoonpark comparativeeffectivenessofpalliativechemotherapyversusneoadjuvantchemotherapyfollowedbyradicalcystectomyversuscystectomyfollowedbyadjuvantchemotherapyversuscystectomyforregionalnodepositivebladdercanceraretrospectiveanalysiskcsggu1703 AT junghoonkim comparativeeffectivenessofpalliativechemotherapyversusneoadjuvantchemotherapyfollowedbyradicalcystectomyversuscystectomyfollowedbyadjuvantchemotherapyversuscystectomyforregionalnodepositivebladdercanceraretrospectiveanalysiskcsggu1703 AT heejunkim comparativeeffectivenessofpalliativechemotherapyversusneoadjuvantchemotherapyfollowedbyradicalcystectomyversuscystectomyfollowedbyadjuvantchemotherapyversuscystectomyforregionalnodepositivebladdercanceraretrospectiveanalysiskcsggu1703 AT chihoonmaeng comparativeeffectivenessofpalliativechemotherapyversusneoadjuvantchemotherapyfollowedbyradicalcystectomyversuscystectomyfollowedbyadjuvantchemotherapyversuscystectomyforregionalnodepositivebladdercanceraretrospectiveanalysiskcsggu1703 AT inkeunpark comparativeeffectivenessofpalliativechemotherapyversusneoadjuvantchemotherapyfollowedbyradicalcystectomyversuscystectomyfollowedbyadjuvantchemotherapyversuscystectomyforregionalnodepositivebladdercanceraretrospectiveanalysiskcsggu1703 AT byeongseoksohn comparativeeffectivenessofpalliativechemotherapyversusneoadjuvantchemotherapyfollowedbyradicalcystectomyversuscystectomyfollowedbyadjuvantchemotherapyversuscystectomyforregionalnodepositivebladdercanceraretrospectiveanalysiskcsggu1703 AT jungakim comparativeeffectivenessofpalliativechemotherapyversusneoadjuvantchemotherapyfollowedbyradicalcystectomyversuscystectomyfollowedbyadjuvantchemotherapyversuscystectomyforregionalnodepositivebladdercanceraretrospectiveanalysiskcsggu1703 AT kyungheelee comparativeeffectivenessofpalliativechemotherapyversusneoadjuvantchemotherapyfollowedbyradicalcystectomyversuscystectomyfollowedbyadjuvantchemotherapyversuscystectomyforregionalnodepositivebladdercanceraretrospectiveanalysiskcsggu1703 AT dohyounglim comparativeeffectivenessofpalliativechemotherapyversusneoadjuvantchemotherapyfollowedbyradicalcystectomyversuscystectomyfollowedbyadjuvantchemotherapyversuscystectomyforregionalnodepositivebladdercanceraretrospectiveanalysiskcsggu1703 AT hyunchang comparativeeffectivenessofpalliativechemotherapyversusneoadjuvantchemotherapyfollowedbyradicalcystectomyversuscystectomyfollowedbyadjuvantchemotherapyversuscystectomyforregionalnodepositivebladdercanceraretrospectiveanalysiskcsggu1703 AT sungminkim comparativeeffectivenessofpalliativechemotherapyversusneoadjuvantchemotherapyfollowedbyradicalcystectomyversuscystectomyfollowedbyadjuvantchemotherapyversuscystectomyforregionalnodepositivebladdercanceraretrospectiveanalysiskcsggu1703 AT hoyoungkim comparativeeffectivenessofpalliativechemotherapyversusneoadjuvantchemotherapyfollowedbyradicalcystectomyversuscystectomyfollowedbyadjuvantchemotherapyversuscystectomyforregionalnodepositivebladdercanceraretrospectiveanalysiskcsggu1703 AT hunhosong comparativeeffectivenessofpalliativechemotherapyversusneoadjuvantchemotherapyfollowedbyradicalcystectomyversuscystectomyfollowedbyadjuvantchemotherapyversuscystectomyforregionalnodepositivebladdercanceraretrospectiveanalysiskcsggu1703 AT seungtaeklim comparativeeffectivenessofpalliativechemotherapyversusneoadjuvantchemotherapyfollowedbyradicalcystectomyversuscystectomyfollowedbyadjuvantchemotherapyversuscystectomyforregionalnodepositivebladdercanceraretrospectiveanalysiskcsggu1703 AT jaehobyun comparativeeffectivenessofpalliativechemotherapyversusneoadjuvantchemotherapyfollowedbyradicalcystectomyversuscystectomyfollowedbyadjuvantchemotherapyversuscystectomyforregionalnodepositivebladdercanceraretrospectiveanalysiskcsggu1703 AT hyunaejung comparativeeffectivenessofpalliativechemotherapyversusneoadjuvantchemotherapyfollowedbyradicalcystectomyversuscystectomyfollowedbyadjuvantchemotherapyversuscystectomyforregionalnodepositivebladdercanceraretrospectiveanalysiskcsggu1703 |
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doaj-a632dcede3e44a2f8402536e55bc7bdf2020-11-24T20:51:10ZengWileyCancer Medicine2045-76342019-09-018125431543710.1002/cam4.2446Comparative effectiveness of palliative chemotherapy versus neoadjuvant chemotherapy followed by radical cystectomy versus cystectomy followed by adjuvant chemotherapy versus cystectomy for regional node‐positive bladder cancer: A retrospective analysis: KCSG GU 17‐03Woo Kyun Bae0Hyo Jin Lee1Se Hoon Park2Jung Hoon Kim3Hee Jun Kim4Chi Hoon Maeng5Inkeun Park6Byeong Seok Sohn7Jung A. Kim8Kyung Hee Lee9Do Hyoung Lim10Hyun Chang11Sung Min Kim12Ho Young Kim13Hunho Song14Seungtaek Lim15Jae Ho Byun16Hyun Ae Jung17Department of Hemato‐Oncology Chonnam National University Medical School Gwangju Republic of KoreaDepartment of Internal Medicine Chungnam National University College of Medicine Daejeon Republic of KoreaDivision of Hematology‐Oncology, Department of Medicine, Samsung Medical Center Sungkyunkwan University School of Medicine Seoul KoreaDepartment of Hemato‐Oncology Gyeongsang National University hospital Jinju Republic of KoreaDepartment of Internal Medicine Chung‐Ang University College of Medicine Seoul KoreaDivision of Medical Oncology‐Hematology, Department of Medicine, College of Medicine Kyung Hee University Hospital Seoul Republic of KoreaDivision of Medical Oncology, Department of Internal medicine Gachon University Gil Medical Center Incheon Republic of KoreaDepartment of Internal Medicine Inje University Sanggye Paik Hospital Seoul Republic of KoreaDivision of Medical Oncology‐Hematology, Department of Medicine, College of Medicine Kangdong Kyung Hee University Hospital Seoul Republic of KoreaDepartment of Hemato‐Oncology, College of Medicine Yeungnam University Daegu Republic of KoreaDepartment of Hemato‐Oncology Dankook University Hospital Cheonan Republic of KoreaDepartment of Medical Oncology Catholic Kwandong University International St. Mary's Hospital Incheon Republic of KoreaDivision of Hematology‐Oncology, Department of Medicine, Samsung Changwon Sungkyunkwan University School of Medicine Changwon KoreaDepartment of Internal Medicine, College of Medicine, Hallym University Medical Center Hallym University Anyang KoreaDepartment of Internal Medicine, College of Medicine, Kangdong Sacred Heart Hospital Hallym University Seoul South KoreaDepartment of Internal Medicine Wonju Severance Christian Hospital Wonju KoreaDivision of Oncology, Department of Internal Medicine, Incheon St. Mary's Hospital The Catholic University of Korea Incheon KoreaDivision of Hematology‐Oncology, Department of Medicine, Samsung Medical Center Sungkyunkwan University School of Medicine Seoul KoreaAbstract The regional lymph node‐positive bladder cancer was classified as stage IV in the AJCC 7th edition but was changed to stage IIIB in the 8th edition, revised in 2018. Among the various studies involving immune checkpoint inhibitors, groups that had only lymph node metastasis showed better outcomes than those with distant metastasis. Therefore, it is necessary to rethink the treatment strategy for lymph node‐positive bladder cancer. The aim of this study was to compare the treatment outcomes of chemotherapy, surgery, and combination therapy in patients with lymph node‐positive bladder cancer. From 1 January 2010 to 31 December 2015, patients with bladder cancer presenting local lymph node metastasis at the time of diagnosis were treated with a single treatment strategy, with either radical cystectomy or chemotherapy or with a combined strategy using both. Treatment outcomes were retrospectively analyzed on the basis of clinical indices and survival time. Out of 230 patients with bladder cancer, 44 (19.1%) were treated with palliative chemotherapy, 30 (13.0%) with neoadjuvant chemotherapy followed by cystectomy, 129 (56.1%) with cystectomy followed by adjuvant chemotherapy, and 27 (11.7%) with cystectomy alone. Median survival among all groups was 30.4 months. For each group, median overall survival was 19.3, 49.1, 42.6, and 11.2 months, respectively. This study represents an advancement in understanding the impact of clinical treatment patterns of lymph node‐positive bladder cancer through comparison of survival data of patients treated with different therapeutic strategies. Combined treatment resulted in better outcomes than did single treatments.https://doi.org/10.1002/cam4.2446bladder cancerchemotherapylymph noderadical cystectomy |