Molecular dynamics-based refinement and validation for sub-5 Å cryo-electron microscopy maps
Two structure determination methods, based on the molecular dynamics flexible fitting (MDFF) paradigm, are presented that resolve sub-5 Å cryo-electron microscopy (EM) maps with either single structures or ensembles of such structures. The methods, denoted cascade MDFF and resolution exchange MDFF,...
Main Authors: | Abhishek Singharoy, Ivan Teo, Ryan McGreevy, John E Stone, Jianhua Zhao, Klaus Schulten |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2016-07-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/16105 |
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