Increasing maternal age is associated with taller stature and reduced abdominal fat in their children.
BACKGROUND: Maternal age at childbirth continues to increase worldwide. We aimed to assess whether increasing maternal age is associated with changes in childhood height, body composition, and metabolism. METHODS: 277 healthy pre-pubertal children, born 37-41 weeks gestation were studied. Assessment...
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doaj-a6420645c1ea42809f7b6d9477ac654a2020-11-24T21:53:57ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0183e5886910.1371/journal.pone.0058869Increasing maternal age is associated with taller stature and reduced abdominal fat in their children.Tim SavageJosé G B DerraikHarriet L MilesFran MouatPaul L HofmanWayne S CutfieldBACKGROUND: Maternal age at childbirth continues to increase worldwide. We aimed to assess whether increasing maternal age is associated with changes in childhood height, body composition, and metabolism. METHODS: 277 healthy pre-pubertal children, born 37-41 weeks gestation were studied. Assessments included: height and weight corrected for parental measurements, DEXA-derived body composition, fasting lipids, glucose, insulin, and hormonal profiles. Subjects were separated according to maternal age at childbirth: <30, 30-35, and >35 years. RESULTS: Our cohort consisted of 126 girls and 151 boys, aged 7.4 ± 2.2 years (range 3-10); maternal age at childbirth was 33.3 ± 4.7 years (range 19-44). Children of mothers aged >35 and 30-35 years at childbirth were taller than children of mothers aged <30 years by 0.26 (p = 0.002) and 0.23 (p = 0.042) SDS, respectively. There was a reduction in childhood BMISDS with increasing maternal age at childbirth, and children of mothers aged >35 years at childbirth were 0.61 SDS slimmer than those of mothers <30 years (p = 0.049). Children of mothers aged 30-35 (p = 0.022) and >35 (p = 0.036) years at childbirth had abdominal adiposity reduced by 10% and 13%, respectively, compared to those in the <30 group. Children of mothers aged 30-35 years at childbirth displayed a 19% increase in IGF-I concentrations compared to offspring in <30 group (p = 0.042). Conversely, IGF-II concentrations were lower among the children born to mothers aged 30-35 (6.5%; p = 0.004) and >35 (8.1%; p = 0.005) compared to those of mothers aged <30 years. Girls of mothers aged 30-35 years at childbirth also displayed improved HOMA-IR insulin sensitivity (p = 0.010) compared to girls born to mothers aged <30 years. CONCLUSIONS: Increasing maternal age at childbirth is associated with a more favourable phenotype (taller stature and reduced abdominal fat) in their children, as well as improved insulin sensitivity in girls.http://europepmc.org/articles/PMC3604016?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tim Savage José G B Derraik Harriet L Miles Fran Mouat Paul L Hofman Wayne S Cutfield |
spellingShingle |
Tim Savage José G B Derraik Harriet L Miles Fran Mouat Paul L Hofman Wayne S Cutfield Increasing maternal age is associated with taller stature and reduced abdominal fat in their children. PLoS ONE |
author_facet |
Tim Savage José G B Derraik Harriet L Miles Fran Mouat Paul L Hofman Wayne S Cutfield |
author_sort |
Tim Savage |
title |
Increasing maternal age is associated with taller stature and reduced abdominal fat in their children. |
title_short |
Increasing maternal age is associated with taller stature and reduced abdominal fat in their children. |
title_full |
Increasing maternal age is associated with taller stature and reduced abdominal fat in their children. |
title_fullStr |
Increasing maternal age is associated with taller stature and reduced abdominal fat in their children. |
title_full_unstemmed |
Increasing maternal age is associated with taller stature and reduced abdominal fat in their children. |
title_sort |
increasing maternal age is associated with taller stature and reduced abdominal fat in their children. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2013-01-01 |
description |
BACKGROUND: Maternal age at childbirth continues to increase worldwide. We aimed to assess whether increasing maternal age is associated with changes in childhood height, body composition, and metabolism. METHODS: 277 healthy pre-pubertal children, born 37-41 weeks gestation were studied. Assessments included: height and weight corrected for parental measurements, DEXA-derived body composition, fasting lipids, glucose, insulin, and hormonal profiles. Subjects were separated according to maternal age at childbirth: <30, 30-35, and >35 years. RESULTS: Our cohort consisted of 126 girls and 151 boys, aged 7.4 ± 2.2 years (range 3-10); maternal age at childbirth was 33.3 ± 4.7 years (range 19-44). Children of mothers aged >35 and 30-35 years at childbirth were taller than children of mothers aged <30 years by 0.26 (p = 0.002) and 0.23 (p = 0.042) SDS, respectively. There was a reduction in childhood BMISDS with increasing maternal age at childbirth, and children of mothers aged >35 years at childbirth were 0.61 SDS slimmer than those of mothers <30 years (p = 0.049). Children of mothers aged 30-35 (p = 0.022) and >35 (p = 0.036) years at childbirth had abdominal adiposity reduced by 10% and 13%, respectively, compared to those in the <30 group. Children of mothers aged 30-35 years at childbirth displayed a 19% increase in IGF-I concentrations compared to offspring in <30 group (p = 0.042). Conversely, IGF-II concentrations were lower among the children born to mothers aged 30-35 (6.5%; p = 0.004) and >35 (8.1%; p = 0.005) compared to those of mothers aged <30 years. Girls of mothers aged 30-35 years at childbirth also displayed improved HOMA-IR insulin sensitivity (p = 0.010) compared to girls born to mothers aged <30 years. CONCLUSIONS: Increasing maternal age at childbirth is associated with a more favourable phenotype (taller stature and reduced abdominal fat) in their children, as well as improved insulin sensitivity in girls. |
url |
http://europepmc.org/articles/PMC3604016?pdf=render |
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