ACUTE EFFECTS OF SYNTHETIC CANNABINOIDS ON VENTRICULAR REPOLARIZATION
Objective: The usage of synthetic cannabinoids (SCs) has increased both in Turkey and all worldwide. Here, we evaluate if SCs cause ventricular repolarization abnormalities using initial and after 12th-hour electrocardiograms in patients with acute intoxication of SCs. We examined changes in the QTc...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Association of medical doctors Sanamed Novi Pazar
2020-12-01
|
Series: | Sanamed |
Subjects: | |
Online Access: | http://www.sanamed.rs/OJS/index.php/Sanamed/article/view/453/241 |
id |
doaj-a6502c99dce844cdaca88756ea13cfa6 |
---|---|
record_format |
Article |
spelling |
doaj-a6502c99dce844cdaca88756ea13cfa62021-01-03T05:02:28ZengAssociation of medical doctors Sanamed Novi PazarSanamed1452-662X2217-81712020-12-0115324925410.24125/sanamed.v15i3.453ACUTE EFFECTS OF SYNTHETIC CANNABINOIDS ON VENTRICULAR REPOLARIZATIONBerat Uguz0Selma Tiryakioglu1Evren Dal2Aysu Kivrak Tihan3Kivanc Yalin4Hakan Ozkan5Bursa City Hospital, Department of Cardiology, Bursa, TurkeyBursa City Hospital, Department of Cardiology, Bursa, TurkeyBursa City Hospital, Department of Emergency, Bursa, TurkeyBursa City Hospital, Department of Psychiatry, Bursa, TurkeyIstanbul University Cerrahpasa Medical Faculty, Department of Cardiology, Istanbul, TurkeyMedicana Hospital, Department of Cardiology, Bursa, TurkeyObjective: The usage of synthetic cannabinoids (SCs) has increased both in Turkey and all worldwide. Here, we evaluate if SCs cause ventricular repolarization abnormalities using initial and after 12th-hour electrocardiograms in patients with acute intoxication of SCs. We examined changes in the QTc and cTp-e parameters to demonstrate ventricular repolarization effects of the usage of SCs. Material and Methods: We used a prospective study design. Twenty patients were included who visited the emergency department, complaining of clouding of consciousness after using SCs. The QT, QTc and Tp-e intervals and several other electrocardiographic parameters were measured at baseline and 12 hours after the usage of SCs. Results: The QRS duration was significantly decreased (102.1±15.5 ms vs 95.0±10.7 ms; p=0.022). We noted a significant decrease in cQT measurements at the end of the 12th hour (426.6±47.2 ms vs 390.4±42.9 ms; p=0.002). Similarly, the Tp-e and cTp-e values decreased significantly when SCs lost its acute effect (93.4±21.1 ms vs 77.4±21.0 ms; p=0.014, 105.3±28.5 ms vs 88.1±21.5 ms; p=0.01). Conclusions: The usage of SCs affects ventricular repolarization heterogeneity based on QTc and Tp-e intervals.http://www.sanamed.rs/OJS/index.php/Sanamed/article/view/453/241synthetic cannabinoidsbonzaiventricular repolarization heterogeneityadverse cardiovascular effects |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Berat Uguz Selma Tiryakioglu Evren Dal Aysu Kivrak Tihan Kivanc Yalin Hakan Ozkan |
spellingShingle |
Berat Uguz Selma Tiryakioglu Evren Dal Aysu Kivrak Tihan Kivanc Yalin Hakan Ozkan ACUTE EFFECTS OF SYNTHETIC CANNABINOIDS ON VENTRICULAR REPOLARIZATION Sanamed synthetic cannabinoids bonzai ventricular repolarization heterogeneity adverse cardiovascular effects |
author_facet |
Berat Uguz Selma Tiryakioglu Evren Dal Aysu Kivrak Tihan Kivanc Yalin Hakan Ozkan |
author_sort |
Berat Uguz |
title |
ACUTE EFFECTS OF SYNTHETIC CANNABINOIDS ON VENTRICULAR REPOLARIZATION |
title_short |
ACUTE EFFECTS OF SYNTHETIC CANNABINOIDS ON VENTRICULAR REPOLARIZATION |
title_full |
ACUTE EFFECTS OF SYNTHETIC CANNABINOIDS ON VENTRICULAR REPOLARIZATION |
title_fullStr |
ACUTE EFFECTS OF SYNTHETIC CANNABINOIDS ON VENTRICULAR REPOLARIZATION |
title_full_unstemmed |
ACUTE EFFECTS OF SYNTHETIC CANNABINOIDS ON VENTRICULAR REPOLARIZATION |
title_sort |
acute effects of synthetic cannabinoids on ventricular repolarization |
publisher |
Association of medical doctors Sanamed Novi Pazar |
series |
Sanamed |
issn |
1452-662X 2217-8171 |
publishDate |
2020-12-01 |
description |
Objective: The usage of synthetic cannabinoids (SCs) has increased both in Turkey and all worldwide. Here, we evaluate if SCs cause ventricular repolarization abnormalities using initial and after 12th-hour electrocardiograms in patients with acute intoxication of SCs. We examined changes in the QTc and cTp-e parameters to demonstrate ventricular repolarization effects of the usage of SCs.
Material and Methods: We used a prospective study design. Twenty patients were included who visited the emergency department, complaining of clouding of consciousness after using SCs. The QT, QTc and Tp-e intervals and several other electrocardiographic parameters were measured at baseline and 12 hours after the usage of SCs.
Results: The QRS duration was significantly decreased (102.1±15.5 ms vs 95.0±10.7 ms; p=0.022). We noted a significant decrease in cQT measurements at the end of the 12th hour (426.6±47.2 ms vs 390.4±42.9 ms; p=0.002). Similarly, the Tp-e and cTp-e values decreased significantly when SCs lost its acute effect (93.4±21.1 ms vs 77.4±21.0 ms; p=0.014, 105.3±28.5 ms vs 88.1±21.5 ms; p=0.01).
Conclusions: The usage of SCs affects ventricular repolarization heterogeneity based on QTc and Tp-e intervals. |
topic |
synthetic cannabinoids bonzai ventricular repolarization heterogeneity adverse cardiovascular effects |
url |
http://www.sanamed.rs/OJS/index.php/Sanamed/article/view/453/241 |
work_keys_str_mv |
AT beratuguz acuteeffectsofsyntheticcannabinoidsonventricularrepolarization AT selmatiryakioglu acuteeffectsofsyntheticcannabinoidsonventricularrepolarization AT evrendal acuteeffectsofsyntheticcannabinoidsonventricularrepolarization AT aysukivraktihan acuteeffectsofsyntheticcannabinoidsonventricularrepolarization AT kivancyalin acuteeffectsofsyntheticcannabinoidsonventricularrepolarization AT hakanozkan acuteeffectsofsyntheticcannabinoidsonventricularrepolarization |
_version_ |
1724351132972613632 |