LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling

LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling

The liver X receptors (LXRs) are transcriptional regulators of lipid homeostasis that also have potent anti-inflammatory effects. The molecular basis for their anti-inflammatory effects is incompletely understood, but has been proposed to involve the indirect tethering of LXRs to inflammatory gene p...

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Bibliographic Details
Main Authors: Ayaka Ito, Cynthia Hong, Xin Rong, Xuewei Zhu, Elizabeth J Tarling, Per Niklas Hedde, Enrico Gratton, John Parks, Peter Tontonoz
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-07-01
Series:eLife
Subjects:
nuclear receptor
LXR
lipid metabolism
Toll-like receptor
Online Access:https://elifesciences.org/articles/08009

Internet

https://elifesciences.org/articles/08009

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