Inhibition of VEGF-C modulates distal lymphatic remodeling and secondary metastasis.

Inhibition of VEGF-C modulates distal lymphatic remodeling and secondary metastasis.

Tumor-associated lymphatics are postulated to provide a transit route for disseminating metastatic cells. This notion is supported by preclinical findings that inhibition of pro-lymphangiogenic signaling during tumor development reduces cell spread to sentinel lymph nodes (SLNs). However, it is uncl...

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Bibliographic Details
Main Authors: Alvin Gogineni, Maresa Caunt, Ailey Crow, Chingwei V Lee, Germaine Fuh, Nicholas van Bruggen, Weilan Ye, Robby M Weimer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23874750/?tool=EBI

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