Clinical Characteristics and Influencing Factors of Esophageal Squamous Cell Carcinoma Patients with Brain Metastases and Their Influence on Survival
Objective To investigate the clinical characteristics and influencing factors of patients with brain metastases from esophageal squamous cell carcinoma (BM-ESCC) and their impact on survival. Methods We retrospectively analyzed the clinical data of 67 patients with newly diagnosed BM-ESCC from Decem...
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2020-06-01
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doaj-a65a0e0a53b4408282ce4c967b5ac06b2020-11-25T03:31:14ZzhoMagazine House of Cancer Research on Prevention and TreatmentZhongliu Fangzhi Yanjiu1000-85781000-85782020-06-0147643744010.3971/j.issn.1000-8578.2020.19.08298578.2020.19.0829Clinical Characteristics and Influencing Factors of Esophageal Squamous Cell Carcinoma Patients with Brain Metastases and Their Influence on SurvivalLUO Huachun0FU Zhichao1FENG Jing2SHEN Zhiyong3YING Wenmin4CAI Lyujuan5CHENG Huihua6Department of Radiotherapy Oncology, Joint Logistics 900 Hospital, Fuzhou 350025, ChinaDepartment of Radiotherapy Oncology, Joint Logistics 900 Hospital, Fuzhou 350025, ChinaDepartment of Radiotherapy Oncology, Joint Logistics 900 Hospital, Fuzhou 350025, ChinaDepartment of Radiotherapy Oncology, Joint Logistics 900 Hospital, Fuzhou 350025, ChinaDepartment of Radiotherapy Oncology, Joint Logistics 900 Hospital, Fuzhou 350025, ChinaDepartment of Radiotherapy Oncology, Joint Logistics 900 Hospital, Fuzhou 350025, ChinaDepartment of Radiotherapy Oncology, Joint Logistics 900 Hospital, Fuzhou 350025, ChinaObjective To investigate the clinical characteristics and influencing factors of patients with brain metastases from esophageal squamous cell carcinoma (BM-ESCC) and their impact on survival. Methods We retrospectively analyzed the clinical data of 67 patients with newly diagnosed BM-ESCC from December 2000 to December 2016 in our hospital, to analyze the correlation of brain metastases with clinicopathological characteristics and the survival. Results The number of BM-ESCC was positively correlated with T and N stages (P < 0.05). The median survival time was 9.65 months. Logistic regression analysis showed that N2 and N3 were risk factors for brain metastasis in patients with esophageal squamous cell carcinoma, and the risk of brain metastasis in patients with N0 and N1 was lower (P < 0.05). Log rank survival analysis reveal that patients with one brain metastasis had a significantly longer survial than those with two and three brain metastasis (P < 0.05); patients with N0+N1 stage had better prognosis than those with N2 and N3 (P < 0.05). Cox regression model showed that T3+T4 stage, N3 stage and whole brain radiotherapy were independent prognostic factors for BM-ESCC patients (P < 0.05). Conclusion In esophageal squamous cell carcinoma patients with brain metastases, the number of brain metastases is positively correlated with T and N stages; the higher N stage is, the higher the risk of brain metastases is; the higher T and N stages are, the worse the prognosis is; whole brain radiotherapy could offer better survival benefits.http://html.rhhz.net/ZLFZYJ/html/8578.2020.19.0829.htmesophageal squamous cell carcinomabrain metastasisrisk factorsprognosiswhole-brain radiotherapy |
collection |
DOAJ |
language |
zho |
format |
Article |
sources |
DOAJ |
author |
LUO Huachun FU Zhichao FENG Jing SHEN Zhiyong YING Wenmin CAI Lyujuan CHENG Huihua |
spellingShingle |
LUO Huachun FU Zhichao FENG Jing SHEN Zhiyong YING Wenmin CAI Lyujuan CHENG Huihua Clinical Characteristics and Influencing Factors of Esophageal Squamous Cell Carcinoma Patients with Brain Metastases and Their Influence on Survival Zhongliu Fangzhi Yanjiu esophageal squamous cell carcinoma brain metastasis risk factors prognosis whole-brain radiotherapy |
author_facet |
LUO Huachun FU Zhichao FENG Jing SHEN Zhiyong YING Wenmin CAI Lyujuan CHENG Huihua |
author_sort |
LUO Huachun |
title |
Clinical Characteristics and Influencing Factors of Esophageal Squamous Cell Carcinoma Patients with Brain Metastases and Their Influence on Survival |
title_short |
Clinical Characteristics and Influencing Factors of Esophageal Squamous Cell Carcinoma Patients with Brain Metastases and Their Influence on Survival |
title_full |
Clinical Characteristics and Influencing Factors of Esophageal Squamous Cell Carcinoma Patients with Brain Metastases and Their Influence on Survival |
title_fullStr |
Clinical Characteristics and Influencing Factors of Esophageal Squamous Cell Carcinoma Patients with Brain Metastases and Their Influence on Survival |
title_full_unstemmed |
Clinical Characteristics and Influencing Factors of Esophageal Squamous Cell Carcinoma Patients with Brain Metastases and Their Influence on Survival |
title_sort |
clinical characteristics and influencing factors of esophageal squamous cell carcinoma patients with brain metastases and their influence on survival |
publisher |
Magazine House of Cancer Research on Prevention and Treatment |
series |
Zhongliu Fangzhi Yanjiu |
issn |
1000-8578 1000-8578 |
publishDate |
2020-06-01 |
description |
Objective To investigate the clinical characteristics and influencing factors of patients with brain metastases from esophageal squamous cell carcinoma (BM-ESCC) and their impact on survival. Methods We retrospectively analyzed the clinical data of 67 patients with newly diagnosed BM-ESCC from December 2000 to December 2016 in our hospital, to analyze the correlation of brain metastases with clinicopathological characteristics and the survival. Results The number of BM-ESCC was positively correlated with T and N stages (P < 0.05). The median survival time was 9.65 months. Logistic regression analysis showed that N2 and N3 were risk factors for brain metastasis in patients with esophageal squamous cell carcinoma, and the risk of brain metastasis in patients with N0 and N1 was lower (P < 0.05). Log rank survival analysis reveal that patients with one brain metastasis had a significantly longer survial than those with two and three brain metastasis (P < 0.05); patients with N0+N1 stage had better prognosis than those with N2 and N3 (P < 0.05). Cox regression model showed that T3+T4 stage, N3 stage and whole brain radiotherapy were independent prognostic factors for BM-ESCC patients (P < 0.05). Conclusion In esophageal squamous cell carcinoma patients with brain metastases, the number of brain metastases is positively correlated with T and N stages; the higher N stage is, the higher the risk of brain metastases is; the higher T and N stages are, the worse the prognosis is; whole brain radiotherapy could offer better survival benefits. |
topic |
esophageal squamous cell carcinoma brain metastasis risk factors prognosis whole-brain radiotherapy |
url |
http://html.rhhz.net/ZLFZYJ/html/8578.2020.19.0829.htm |
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