Postmortem Studies of Fetal Grafts in Parkinson’s Disease: What Lessons Have We Learned?
Neural transplantation is a potential therapeutic method for Parkinson’s disease (PD). Fetal dopaminergic (DA) neurons have been important transplantation cell sources in the history of replacement therapy for PD. Several decades of preclinical animal experiments and clinical trials using fetal DA n...
Main Authors: | , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2021-05-01
|
Series: | Frontiers in Cell and Developmental Biology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.666675/full |
id |
doaj-a660a87f78d84555a78d19f1217c76fb |
---|---|
record_format |
Article |
spelling |
doaj-a660a87f78d84555a78d19f1217c76fb2021-05-13T05:06:58ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-05-01910.3389/fcell.2021.666675666675Postmortem Studies of Fetal Grafts in Parkinson’s Disease: What Lessons Have We Learned?Jia-Yi Li0Jia-Yi Li1Wen Li2Wen Li3Laboratory of Neurodegenerative Diseases and Repair, Institute of Health Sciences, China Medical University, Shenyang, ChinaNeural Plasticity and Repair Unit, Wallenberg Neuroscience Centre, Department of Experimental Medical Science, Lund University, Lund, SwedenLaboratory of Neurodegenerative Diseases and Repair, Institute of Health Sciences, China Medical University, Shenyang, ChinaNeural Plasticity and Repair Unit, Wallenberg Neuroscience Centre, Department of Experimental Medical Science, Lund University, Lund, SwedenNeural transplantation is a potential therapeutic method for Parkinson’s disease (PD). Fetal dopaminergic (DA) neurons have been important transplantation cell sources in the history of replacement therapy for PD. Several decades of preclinical animal experiments and clinical trials using fetal DA neuron transplantation in PD therapy have shown not only promising results but also problems. In order to reveal possible factors influencing the clinical outcomes, we reviewed fetal DA neuron transplantation therapies from 1970s to present, with a special focus on postmortem studies. Firstly, we gave a general description of the clinical outcomes and neuroanatomy of grafted cases; secondly, we summarized the main available postmortem studies, including the cell survival, reinnervation, and pathology development. In the end, we further discussed the link between function and structure of the grafts, seeking for the possible factors contributing to a functional graft. With our review, we hope to provide references for future transplantation trials from a histological point of view.https://www.frontiersin.org/articles/10.3389/fcell.2021.666675/fullParkinson’s diseasegraftsLewy pathologypostmortem studiestransplantation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jia-Yi Li Jia-Yi Li Wen Li Wen Li |
spellingShingle |
Jia-Yi Li Jia-Yi Li Wen Li Wen Li Postmortem Studies of Fetal Grafts in Parkinson’s Disease: What Lessons Have We Learned? Frontiers in Cell and Developmental Biology Parkinson’s disease grafts Lewy pathology postmortem studies transplantation |
author_facet |
Jia-Yi Li Jia-Yi Li Wen Li Wen Li |
author_sort |
Jia-Yi Li |
title |
Postmortem Studies of Fetal Grafts in Parkinson’s Disease: What Lessons Have We Learned? |
title_short |
Postmortem Studies of Fetal Grafts in Parkinson’s Disease: What Lessons Have We Learned? |
title_full |
Postmortem Studies of Fetal Grafts in Parkinson’s Disease: What Lessons Have We Learned? |
title_fullStr |
Postmortem Studies of Fetal Grafts in Parkinson’s Disease: What Lessons Have We Learned? |
title_full_unstemmed |
Postmortem Studies of Fetal Grafts in Parkinson’s Disease: What Lessons Have We Learned? |
title_sort |
postmortem studies of fetal grafts in parkinson’s disease: what lessons have we learned? |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cell and Developmental Biology |
issn |
2296-634X |
publishDate |
2021-05-01 |
description |
Neural transplantation is a potential therapeutic method for Parkinson’s disease (PD). Fetal dopaminergic (DA) neurons have been important transplantation cell sources in the history of replacement therapy for PD. Several decades of preclinical animal experiments and clinical trials using fetal DA neuron transplantation in PD therapy have shown not only promising results but also problems. In order to reveal possible factors influencing the clinical outcomes, we reviewed fetal DA neuron transplantation therapies from 1970s to present, with a special focus on postmortem studies. Firstly, we gave a general description of the clinical outcomes and neuroanatomy of grafted cases; secondly, we summarized the main available postmortem studies, including the cell survival, reinnervation, and pathology development. In the end, we further discussed the link between function and structure of the grafts, seeking for the possible factors contributing to a functional graft. With our review, we hope to provide references for future transplantation trials from a histological point of view. |
topic |
Parkinson’s disease grafts Lewy pathology postmortem studies transplantation |
url |
https://www.frontiersin.org/articles/10.3389/fcell.2021.666675/full |
work_keys_str_mv |
AT jiayili postmortemstudiesoffetalgraftsinparkinsonsdiseasewhatlessonshavewelearned AT jiayili postmortemstudiesoffetalgraftsinparkinsonsdiseasewhatlessonshavewelearned AT wenli postmortemstudiesoffetalgraftsinparkinsonsdiseasewhatlessonshavewelearned AT wenli postmortemstudiesoffetalgraftsinparkinsonsdiseasewhatlessonshavewelearned |
_version_ |
1721442802085134336 |