Prediction for vascular mild cognitive impairment using the p300 event-related potentials technique

• Main Authors: Yu. V. Sturova, N. R. Plotnikova, G. A. Kostomarova, E. R. Barantsevich, O. V. Posokhina, E. V. Verbitskaya
• Format: Article
• Language: Russian
• Published: Ministry of Healthcare of the Russian Federation. “Kuban State Medical University” 2014-10-01
• Series: Кубанский научный медицинский вестник
• Subjects: умеренные когнитивные расстройства; когнитивные расстройства цереброваскулярной этиологии; слуховые когнитивные вызванные потенциалы р300; латентный период р300; mild cognitive impairment; vascular cognitive impairment; the auditory p300 event-related potentials; p300 latent period
• Online Access: https://ksma.elpub.ru/jour/article/view/219

Evoked potentials technique owing to informativeness and diagnostic value is widely used in clinical and experimental studies. Herein, we investigated whether the auditory P300 event-related potentials predict syndrome vascular mild cognitive impairment. 42 patients with I and II stages of discirulatory encephalopathy (50-70 years) included in clinical study. The discriminant analysis method was used to work out an equation with two variables as predictors - the P300 latent period and patient's age. The diagnostic accuracy of the discriminant equation at a cut-off -0,268 was established through receiver operating characteristic (ROC) analysis (sensitivity 80%, specificity 74,1%).