Formononetin Regulates Multiple Oncogenic Signaling Cascades and Enhances Sensitivity to Bortezomib in a Multiple Myeloma Mouse Model

Formononetin Regulates Multiple Oncogenic Signaling Cascades and Enhances Sensitivity to Bortezomib in a Multiple Myeloma Mouse Model

Here, we determined the anti-neoplastic actions of formononetin (FT) against multiple myeloma (MM) and elucidated its possible mode of action. It was observed that FT enhanced the apoptosis caused by bortezomib (Bor) and mitigated proliferation in MM cells, and these events are regulated by nuclear...

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Bibliographic Details
Main Authors: Chulwon Kim, Jong Hyun Lee, Jeong-Hyeon Ko, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Omar H.M. Shair, Gautam Sethi, Kwang Seok Ahn
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Biomolecules
Subjects:
Formononetin
bortezomib
NF-κB
PI3K/AKT
AP-1
Online Access:https://www.mdpi.com/2218-273X/9/7/262

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