Chemical Starting Matter for HNF4α Ligand Discovery and Chemogenomics

Chemical Starting Matter for HNF4α Ligand Discovery and Chemogenomics

Hepatocyte nuclear factor 4α (HNF4α) is a ligand-sensing transcription factor and presents as a potential drug target in metabolic diseases and cancer. In humans, mutations in the HNF4α gene cause maturity-onset diabetes of the young (MODY), and the elevated activity of this protein has been associa...

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Bibliographic Details
Main Authors: Isabelle Meijer, Sabine Willems, Xiaomin Ni, Jan Heering, Apirat Chaikuad, Daniel Merk
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
Orphan nuclear receptor
hepatocyte nuclear factor 4α
MODY
type 2 diabetes
fragment-based design
drug discovery
Online Access:https://www.mdpi.com/1422-0067/21/21/7895

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