Sebaceous carcinoma masquerade syndrome: Importance of biopsy and histopathological examination

• Main Authors: Ali Salimi, Sabrina Bergeron, Bryan Arthurs, Miguel N. Burnier, Jr.
• Format: Article
• Language: English
• Published: Elsevier 2020-09-01
• Series: Human Pathology: Case Reports
• Subjects: Chalazion; Sebaceous carcinoma; Masquerade syndrome; Pathology; Biopsy
• Online Access: http://www.sciencedirect.com/science/article/pii/S2214330020300596

Sebaceous carcinoma (SebCa), is the second most frequent malignancy of the eyelid. It often presents with non-specific clinical features and is known for mimicking benign inflammatory lesions such as chalazion. The masquerading ability of this highly invasive neoplasm can delay or mislead the diagnosis, resulting in significant morbidity and mortality. Here, we report a rare case of a 91-year-old man presenting with a lesion clinically apparent to a chalazion with a histopathologically proven diagnosis of SebCa adjacent to a chalazion. This report highlights the presentation of sebaceous carcinoma masquerade syndrome and supports a thorough histopathological examination of all surgically excised chalazions.