That’s my story, and I’m sticking to it- an update on B. burgdorferi adhesins
Adhesion is the initial event in the establishment of any infection. Borrelia burgdorferi, the etiological agent of Lyme disease, possesses myriad proteins termed adhesins that facilitate contact with its vertebrate hosts. B. burgdorferi adheres to host tissues through interactions with host cells a...
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doaj-a694ef669af8485bb04a575de80a4cd82020-11-24T20:59:10ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882014-04-01410.3389/fcimb.2014.0004179468That’s my story, and I’m sticking to it- an update on B. burgdorferi adhesinsCatherine Ayn Brissette0Robert A Gaultney1University of North Dakota School of Medicine and Health SciencesUniversity of North Dakota School of Medicine and Health SciencesAdhesion is the initial event in the establishment of any infection. Borrelia burgdorferi, the etiological agent of Lyme disease, possesses myriad proteins termed adhesins that facilitate contact with its vertebrate hosts. B. burgdorferi adheres to host tissues through interactions with host cells and extracellular matrix, as well as other molecules present in serum and extracellular fluids. These interactions, both general and specific, are critical in the establishment of infection. Modulation of borrelial adhesion to host tissues affects the microorganisms ’s ability to colonize, disseminate, and persist. In this review, we update the current knowledge on structure, function, and role in pathogenesis of these sticky B. burgdorferi infection-associated proteins.http://journal.frontiersin.org/Journal/10.3389/fcimb.2014.00041/fullBorrelia burgdorferiDecorinExtracellular MatrixIntegrinsLyme Diseasefibronectin |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Catherine Ayn Brissette Robert A Gaultney |
spellingShingle |
Catherine Ayn Brissette Robert A Gaultney That’s my story, and I’m sticking to it- an update on B. burgdorferi adhesins Frontiers in Cellular and Infection Microbiology Borrelia burgdorferi Decorin Extracellular Matrix Integrins Lyme Disease fibronectin |
author_facet |
Catherine Ayn Brissette Robert A Gaultney |
author_sort |
Catherine Ayn Brissette |
title |
That’s my story, and I’m sticking to it- an update on B. burgdorferi adhesins |
title_short |
That’s my story, and I’m sticking to it- an update on B. burgdorferi adhesins |
title_full |
That’s my story, and I’m sticking to it- an update on B. burgdorferi adhesins |
title_fullStr |
That’s my story, and I’m sticking to it- an update on B. burgdorferi adhesins |
title_full_unstemmed |
That’s my story, and I’m sticking to it- an update on B. burgdorferi adhesins |
title_sort |
that’s my story, and i’m sticking to it- an update on b. burgdorferi adhesins |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cellular and Infection Microbiology |
issn |
2235-2988 |
publishDate |
2014-04-01 |
description |
Adhesion is the initial event in the establishment of any infection. Borrelia burgdorferi, the etiological agent of Lyme disease, possesses myriad proteins termed adhesins that facilitate contact with its vertebrate hosts. B. burgdorferi adheres to host tissues through interactions with host cells and extracellular matrix, as well as other molecules present in serum and extracellular fluids. These interactions, both general and specific, are critical in the establishment of infection. Modulation of borrelial adhesion to host tissues affects the microorganisms ’s ability to colonize, disseminate, and persist. In this review, we update the current knowledge on structure, function, and role in pathogenesis of these sticky B. burgdorferi infection-associated proteins. |
topic |
Borrelia burgdorferi Decorin Extracellular Matrix Integrins Lyme Disease fibronectin |
url |
http://journal.frontiersin.org/Journal/10.3389/fcimb.2014.00041/full |
work_keys_str_mv |
AT catherineaynbrissette thatsmystoryandimstickingtoitanupdateonbburgdorferiadhesins AT robertagaultney thatsmystoryandimstickingtoitanupdateonbburgdorferiadhesins |
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