Citrate-Induced p85α–PTEN Complex Formation Causes G<sub>2</sub>/M Phase Arrest in Human Pharyngeal Squamous Carcinoma Cell Lines
Citrate is a key intermediate of the tricarboxylic acid cycle and acts as an allosteric signal to regulate the production of cellular ATP. An elevated cytosolic citrate concentration inhibits growth in several types of human cancer cells; however, the underlying mechanism by which citrate induces th...
Main Authors: | Kuang-Chen Hung, Shyang-Guang Wang, Meng-Liang Lin, Shih-Shun Chen |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2019-04-01
|
Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/20/9/2105 |
Similar Items
-
Enhanced SO<sub>2</sub> Absorption Capacity of Sodium Citrate Using Sodium Humate
by: Zhiguo Sun, et al.
Published: (2021-07-01) -
Formononetin Promotes Cell Cycle Arrest via Downregulation of Akt/Cyclin D1/CDK4 in Human Prostate Cancer Cells
by: Tianyu Li, et al.
Published: (2014-10-01) -
Annexin A2 Regulates AKT Upon H<sub>2</sub>O<sub>2</sub>-Dependent Signaling Activation in Cancer Cells
by: Stéphanie Anais Castaldo, et al.
Published: (2019-04-01) -
Fumonisin B<sub>1</sub> Epigenetically Regulates PTEN Expression and Modulates DNA Damage Checkpoint Regulation in HepG2 Liver Cells
by: Thilona Arumugam, et al.
Published: (2020-09-01) -
G<sub>1</sub> Cell Cycle Arrest and Extrinsic Apoptotic Mechanisms Underlying the Anti-Leukemic Activity of CDK7 Inhibitor BS-181
by: Shin Young Park, et al.
Published: (2020-12-01)