Effect and current reseaches of extracellular matrix remodeling on primary open angle glaucoma
Glaucoma is characterized by optic atrophy and visual field defect. The pathological elevated intraocular pressure is the leading risk factor for glaucoma. The pathological characteristic of glaucoma is apoptosis of retinal ganglion cells(RGCs)and their axon loss. Changes of the amounts and composit...
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doaj-a699af1fd6b9487582a9be25f1647a0f2020-11-24T21:04:45ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51231672-51232016-04-0116465465610.3980/j.issn.1672-5123.2016.4.16Effect and current reseaches of extracellular matrix remodeling on primary open angle glaucomaYu Pang0Ling Yu1Department of Ophthalmology, the First Affiliated Hospital of Sichuan Medical University, Luzhou 646000, Sichuan Province, ChinaDepartment of Ophthalmology, the First Affiliated Hospital of Sichuan Medical University, Luzhou 646000, Sichuan Province, ChinaGlaucoma is characterized by optic atrophy and visual field defect. The pathological elevated intraocular pressure is the leading risk factor for glaucoma. The pathological characteristic of glaucoma is apoptosis of retinal ganglion cells(RGCs)and their axon loss. Changes of the amounts and compositions of the extracellular matrix(ECM)play a crucial role in the structure of trabecular meshwork, lamina cribrose of opitic nerve head and the apoptosis of RGCs. The expression of transforming growth factor-β2(TGF-β2)increases in trabecular meshwork and aqueous humor for glaucomatic patients, which leads to elevated intraocular pressure by secretion and accumulation of ECM. Elevated intraocular pressure causes changes in ECM of optic nerve head and retina, resulting in blocked transport of neurotrophins, the high level of matrix metalloproteinase(MMPs)-9 and low level of laminin respectively, which eventually lead to the apoptosis of RGCs. Therefore, it is important to understand the relationship between ECM and glaucoma, which may provide a new direction for glaucomatous pathogenesis and therapy.http://ies.ijo.cn/cn_publish/2016/4/201604016.pdfextracellular matrixprimary open angle glaucomaretinal ganglion cells |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yu Pang Ling Yu |
spellingShingle |
Yu Pang Ling Yu Effect and current reseaches of extracellular matrix remodeling on primary open angle glaucoma Guoji Yanke Zazhi extracellular matrix primary open angle glaucoma retinal ganglion cells |
author_facet |
Yu Pang Ling Yu |
author_sort |
Yu Pang |
title |
Effect and current reseaches of extracellular matrix remodeling on primary open angle glaucoma |
title_short |
Effect and current reseaches of extracellular matrix remodeling on primary open angle glaucoma |
title_full |
Effect and current reseaches of extracellular matrix remodeling on primary open angle glaucoma |
title_fullStr |
Effect and current reseaches of extracellular matrix remodeling on primary open angle glaucoma |
title_full_unstemmed |
Effect and current reseaches of extracellular matrix remodeling on primary open angle glaucoma |
title_sort |
effect and current reseaches of extracellular matrix remodeling on primary open angle glaucoma |
publisher |
Press of International Journal of Ophthalmology (IJO PRESS) |
series |
Guoji Yanke Zazhi |
issn |
1672-5123 1672-5123 |
publishDate |
2016-04-01 |
description |
Glaucoma is characterized by optic atrophy and visual field defect. The pathological elevated intraocular pressure is the leading risk factor for glaucoma. The pathological characteristic of glaucoma is apoptosis of retinal ganglion cells(RGCs)and their axon loss. Changes of the amounts and compositions of the extracellular matrix(ECM)play a crucial role in the structure of trabecular meshwork, lamina cribrose of opitic nerve head and the apoptosis of RGCs. The expression of transforming growth factor-β2(TGF-β2)increases in trabecular meshwork and aqueous humor for glaucomatic patients, which leads to elevated intraocular pressure by secretion and accumulation of ECM. Elevated intraocular pressure causes changes in ECM of optic nerve head and retina, resulting in blocked transport of neurotrophins, the high level of matrix metalloproteinase(MMPs)-9 and low level of laminin respectively, which eventually lead to the apoptosis of RGCs. Therefore, it is important to understand the relationship between ECM and glaucoma, which may provide a new direction for glaucomatous pathogenesis and therapy. |
topic |
extracellular matrix primary open angle glaucoma retinal ganglion cells |
url |
http://ies.ijo.cn/cn_publish/2016/4/201604016.pdf |
work_keys_str_mv |
AT yupang effectandcurrentreseachesofextracellularmatrixremodelingonprimaryopenangleglaucoma AT lingyu effectandcurrentreseachesofextracellularmatrixremodelingonprimaryopenangleglaucoma |
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