Reciprocal regulatory circuits coordinating EMT plasticity
Epithelial to mesenchymal transition (EMT) as well as its reversal process, mesenchymal to epithelial transition (MET), are essential and well-controlled cellular processes during embryonic development. Tightly controlled regulatory mechanisms guide an EMT/MET plasticity and enable cells to switch f...
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doaj-a6a86d7f41b54dfa9171d87e5cde07ef2020-11-24T22:02:55ZengShared Science Publishers OGCell Stress2523-02042017-12-011313914010.15698/cst2017.12.117Reciprocal regulatory circuits coordinating EMT plasticityMaren Diepenbruck0Gerhard Christofori1Department of Biomedicine, University of Basel, 4058 Basel, Switzerland.Department of Biomedicine, University of Basel, 4058 Basel, Switzerland.Epithelial to mesenchymal transition (EMT) as well as its reversal process, mesenchymal to epithelial transition (MET), are essential and well-controlled cellular processes during embryonic development. Tightly controlled regulatory mechanisms guide an EMT/MET plasticity and enable cells to switch forth and back between different cell morphologies and functional capabilities to endow the necessity of tissue plasticity. However, aberrant and uncontrolled activation of these processes during malignant tumor progression promotes primary tumor cell invasion, cancer cell dissemination and metastatic outgrowth. In a recent study (Nat Commun; doi: 10.1038/s41467-017-01197-w), we have reported on the post-transcriptional control of normal and cancer-associated EMT by miRNAs and identified a novel, critical double-negative feedback regulation of the thus far unknown miRNA miR1199 and the key EMT transcription factor Zeb1.http://www.cell-stress.com/researcharticles/reciprocal-regulatory-circuits-coordinating-emt-plasticity/EMTinvasionmiRNAsmetastasistranscription factors |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Maren Diepenbruck Gerhard Christofori |
spellingShingle |
Maren Diepenbruck Gerhard Christofori Reciprocal regulatory circuits coordinating EMT plasticity Cell Stress EMT invasion miRNAs metastasis transcription factors |
author_facet |
Maren Diepenbruck Gerhard Christofori |
author_sort |
Maren Diepenbruck |
title |
Reciprocal regulatory circuits coordinating EMT plasticity |
title_short |
Reciprocal regulatory circuits coordinating EMT plasticity |
title_full |
Reciprocal regulatory circuits coordinating EMT plasticity |
title_fullStr |
Reciprocal regulatory circuits coordinating EMT plasticity |
title_full_unstemmed |
Reciprocal regulatory circuits coordinating EMT plasticity |
title_sort |
reciprocal regulatory circuits coordinating emt plasticity |
publisher |
Shared Science Publishers OG |
series |
Cell Stress |
issn |
2523-0204 |
publishDate |
2017-12-01 |
description |
Epithelial to mesenchymal transition (EMT) as well as its reversal process, mesenchymal to epithelial transition (MET), are essential and well-controlled cellular processes during embryonic development. Tightly controlled regulatory mechanisms guide an EMT/MET plasticity and enable cells to switch forth and back between different cell morphologies and functional capabilities to endow the necessity of tissue plasticity. However, aberrant and uncontrolled activation of these processes during malignant tumor progression promotes primary tumor cell invasion, cancer cell dissemination and metastatic outgrowth. In a recent study (Nat Commun; doi: 10.1038/s41467-017-01197-w), we have reported on the post-transcriptional control of normal and cancer-associated EMT by miRNAs and identified a novel, critical double-negative feedback regulation of the thus far unknown miRNA miR1199 and the key EMT transcription factor Zeb1. |
topic |
EMT invasion miRNAs metastasis transcription factors |
url |
http://www.cell-stress.com/researcharticles/reciprocal-regulatory-circuits-coordinating-emt-plasticity/ |
work_keys_str_mv |
AT marendiepenbruck reciprocalregulatorycircuitscoordinatingemtplasticity AT gerhardchristofori reciprocalregulatorycircuitscoordinatingemtplasticity |
_version_ |
1725834021855821824 |