Increased acetylation of microtubules rescues human tau-induced microtubule defects and neuromuscular junction abnormalities in Drosophila

Tau normally associates with and stabilizes microtubules (MTs), but is hyperphosphorylated and aggregated into neurofibrillary tangles in Alzheimer's disease and related neurodegenerative diseases, which are collectively known as tauopathies. MTs are regulated by different forms of post-transla...

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Bibliographic Details
Main Authors: Chuan-Xi Mao, Xue Wen, Shan Jin, Yong Q. Zhang
Format: Article
Language:English
Published: The Company of Biologists 2017-10-01
Series:Disease Models & Mechanisms
Subjects:
Online Access:http://dmm.biologists.org/content/10/10/1245

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