Lack of Frank Agrammatism in the Nonfluent Agrammatic Variant of Primary Progressive Aphasia
Background/Aims: Frank agrammatism, defined as the omission and/or substitution of grammatical morphemes with associated grammatical errors, is variably reported in patients with nonfluent variant primary progressive aphasia (nfPPA). This study addressed whether frank agrammatism is typical in agram...
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doaj-a6b8d83052e2468e9a7f8663c366797e2020-11-25T03:41:46ZengKarger PublishersDementia and Geriatric Cognitive Disorders Extra1664-54642016-09-016340742310.1159/000448944448944Lack of Frank Agrammatism in the Nonfluent Agrammatic Variant of Primary Progressive AphasiaNaida L. GrahamCarol LeonardDavid F. Tang-WaiSandra BlackTiffany W. ChowChris J.M. ScottAlicia A. McNeelyMario MasellisElizabeth RochonBackground/Aims: Frank agrammatism, defined as the omission and/or substitution of grammatical morphemes with associated grammatical errors, is variably reported in patients with nonfluent variant primary progressive aphasia (nfPPA). This study addressed whether frank agrammatism is typical in agrammatic nfPPA patients when this feature is not required for diagnosis. Method: We assessed grammatical production in 9 patients who satisfied current diagnostic criteria. Although the focus was agrammatism, motor speech skills were also evaluated to determine whether dysfluency arose primarily from apraxia of speech (AOS), instead of, or in addition to, agrammatism. Volumetric MRI analyses provided impartial imaging-supported diagnosis. Results: The majority of cases exhibited neither frank agrammatism nor AOS. Conclusion: There are nfPPA patients with imaging-supported diagnosis and preserved motor speech skills who do not exhibit frank agrammatism, and this may persist beyond the earliest stages of the illness. Because absence of frank agrammatism is a subsidiary diagnostic feature in the logopenic variant of PPA, this result has implications for differentiation of the nonfluent and logopenic variants, and indicates that PPA patients with nonfluent speech in the absence of frank agrammatism or AOS do not necessarily have the logopenic variant.http://www.karger.com/Article/FullText/448944Diagnostic criteriaFrontotemporal dementiaApraxia of speechDifferential diagnosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Naida L. Graham Carol Leonard David F. Tang-Wai Sandra Black Tiffany W. Chow Chris J.M. Scott Alicia A. McNeely Mario Masellis Elizabeth Rochon |
spellingShingle |
Naida L. Graham Carol Leonard David F. Tang-Wai Sandra Black Tiffany W. Chow Chris J.M. Scott Alicia A. McNeely Mario Masellis Elizabeth Rochon Lack of Frank Agrammatism in the Nonfluent Agrammatic Variant of Primary Progressive Aphasia Dementia and Geriatric Cognitive Disorders Extra Diagnostic criteria Frontotemporal dementia Apraxia of speech Differential diagnosis |
author_facet |
Naida L. Graham Carol Leonard David F. Tang-Wai Sandra Black Tiffany W. Chow Chris J.M. Scott Alicia A. McNeely Mario Masellis Elizabeth Rochon |
author_sort |
Naida L. Graham |
title |
Lack of Frank Agrammatism in the Nonfluent Agrammatic Variant of Primary Progressive Aphasia |
title_short |
Lack of Frank Agrammatism in the Nonfluent Agrammatic Variant of Primary Progressive Aphasia |
title_full |
Lack of Frank Agrammatism in the Nonfluent Agrammatic Variant of Primary Progressive Aphasia |
title_fullStr |
Lack of Frank Agrammatism in the Nonfluent Agrammatic Variant of Primary Progressive Aphasia |
title_full_unstemmed |
Lack of Frank Agrammatism in the Nonfluent Agrammatic Variant of Primary Progressive Aphasia |
title_sort |
lack of frank agrammatism in the nonfluent agrammatic variant of primary progressive aphasia |
publisher |
Karger Publishers |
series |
Dementia and Geriatric Cognitive Disorders Extra |
issn |
1664-5464 |
publishDate |
2016-09-01 |
description |
Background/Aims: Frank agrammatism, defined as the omission and/or substitution of grammatical morphemes with associated grammatical errors, is variably reported in patients with nonfluent variant primary progressive aphasia (nfPPA). This study addressed whether frank agrammatism is typical in agrammatic nfPPA patients when this feature is not required for diagnosis. Method: We assessed grammatical production in 9 patients who satisfied current diagnostic criteria. Although the focus was agrammatism, motor speech skills were also evaluated to determine whether dysfluency arose primarily from apraxia of speech (AOS), instead of, or in addition to, agrammatism. Volumetric MRI analyses provided impartial imaging-supported diagnosis. Results: The majority of cases exhibited neither frank agrammatism nor AOS. Conclusion: There are nfPPA patients with imaging-supported diagnosis and preserved motor speech skills who do not exhibit frank agrammatism, and this may persist beyond the earliest stages of the illness. Because absence of frank agrammatism is a subsidiary diagnostic feature in the logopenic variant of PPA, this result has implications for differentiation of the nonfluent and logopenic variants, and indicates that PPA patients with nonfluent speech in the absence of frank agrammatism or AOS do not necessarily have the logopenic variant. |
topic |
Diagnostic criteria Frontotemporal dementia Apraxia of speech Differential diagnosis |
url |
http://www.karger.com/Article/FullText/448944 |
work_keys_str_mv |
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