Circulating Exosomal Integrin β3 Is Associated with Intracranial Failure and Survival in Lung Cancer Patients Receiving Cranial Irradiation for Brain Metastases: A Prospective Observational Study

Circulating Exosomal Integrin β3 Is Associated with Intracranial Failure and Survival in Lung Cancer Patients Receiving Cranial Irradiation for Brain Metastases: A Prospective Observational Study

Brain metastasis (BM) is a major problem in patients with cancer. Exosomes or extracellular vesicles (EV) and integrins contribute to the development of BM, and exosomal integrins have been shown to determine organotropic metastasis. We hypothesized that circulating EV integrins are able to influenc...

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Bibliographic Details
Main Authors: Guann-Yiing Chen, Jason Chia-Hsien Cheng, Ya-Fang Chen, James Chih-Hsin Yang, Feng-Ming Hsu
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Cancers
Subjects:
brain metastasis
whole brain radiotherapy
circulating exosomes
exosomal integrins
extracellular vesicles
biomarker
Online Access:https://www.mdpi.com/2072-6694/13/3/380

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