Agr typing of Staphylococcus aureus species isolated from clinical samples in training hospitals of Isfahan and Shahrekord

• Main Authors: Saeid Javdan, Tahmine Narimani, Milad Shahini Shams Abadi, Abolfazl Gholipour
• Format: Article
• Language: English
• Published: BMC 2019-06-01
• Series: BMC Research Notes
• Subjects: Staphylococcus aureus; Agr type; mecA gene; Antibiotic resistance; Methicillin
• Online Access: http://link.springer.com/article/10.1186/s13104-019-4396-8

Abstract Objective As an opportunistic pathogen, Staphylococcus aureus is associated with serious nosocomial infections and growing antimicrobial resistance against beta-lactams among S. aureus strains has become a global challenge. The current study was designed to investigate the presence of agr genes among S. aureus strains recovered from clinical samples in university hospitals of Isfahan and Shahrekord. Results A total of 150 S. aureus isolates were screened by Disk diffusion method (DDM) and conventional PCR. The minimum (17.3%) and maximum (46%) antibiotic resistance rates were found in vancomycin and cefoxitin, respectively. The majority of our isolates were classified as agr type I followed by type II, type IV, and type III. The statistical analysis showed a significant correlation between agr type I and antibiotic resistance against cefoxitin and erythromycin (p = 0.04 and p = 0.03, respectively). Based on our findings, the agr typing could be considered an effective approach for molecular tracking of S. aureus infections.