The Role of Sialyl-Tn in Cancer
Activation of an aberrant glycosylation pathway in cancer cells can lead to expression of the onco-foetal sialyl-Tn (sTn) antigen. STn is a truncated O-glycan containing a sialic acid α-2,6 linked to GalNAc α-O-Ser/Thr and is linked with an adverse outcome and poor prognosis in cancer patients. The...
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doaj-a6d8a50bf5aa417ead81c203a6f92add2020-11-24T22:22:24ZengMDPI AGInternational Journal of Molecular Sciences1422-00672016-02-0117327510.3390/ijms17030275ijms17030275The Role of Sialyl-Tn in CancerJennifer Munkley0Institute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne NE1 3BZ, UKActivation of an aberrant glycosylation pathway in cancer cells can lead to expression of the onco-foetal sialyl-Tn (sTn) antigen. STn is a truncated O-glycan containing a sialic acid α-2,6 linked to GalNAc α-O-Ser/Thr and is linked with an adverse outcome and poor prognosis in cancer patients. The biosynthesis of the sTn antigen has been linked to the expression of the sialytransferase ST6GalNAc1, and also to mutations in and loss of heterozygosity of the COSMC gene. sTn neo- or over-expression occurs in many types of epithelial cancer including gastric, colon, breast, lung, oesophageal, prostate and endometrial cancer. sTn is believed to be carried by a variety of glycoproteins and may influence protein function and be involved in tumour development. This review discusses how the role of sTn in cancer development and tumour cell invasiveness might be organ specific and occur through different mechanisms depending on each cancer type or subtype. As the sTn-antigen is expressed early in carcinogenesis targeting sTn in cancer may enable the targeting of tumours from the earliest stage.http://www.mdpi.com/1422-0067/17/3/275sialyl-TncancerO-glycansST6GalNAc1COSMCglycosylation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jennifer Munkley |
spellingShingle |
Jennifer Munkley The Role of Sialyl-Tn in Cancer International Journal of Molecular Sciences sialyl-Tn cancer O-glycans ST6GalNAc1 COSMC glycosylation |
author_facet |
Jennifer Munkley |
author_sort |
Jennifer Munkley |
title |
The Role of Sialyl-Tn in Cancer |
title_short |
The Role of Sialyl-Tn in Cancer |
title_full |
The Role of Sialyl-Tn in Cancer |
title_fullStr |
The Role of Sialyl-Tn in Cancer |
title_full_unstemmed |
The Role of Sialyl-Tn in Cancer |
title_sort |
role of sialyl-tn in cancer |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2016-02-01 |
description |
Activation of an aberrant glycosylation pathway in cancer cells can lead to expression of the onco-foetal sialyl-Tn (sTn) antigen. STn is a truncated O-glycan containing a sialic acid α-2,6 linked to GalNAc α-O-Ser/Thr and is linked with an adverse outcome and poor prognosis in cancer patients. The biosynthesis of the sTn antigen has been linked to the expression of the sialytransferase ST6GalNAc1, and also to mutations in and loss of heterozygosity of the COSMC gene. sTn neo- or over-expression occurs in many types of epithelial cancer including gastric, colon, breast, lung, oesophageal, prostate and endometrial cancer. sTn is believed to be carried by a variety of glycoproteins and may influence protein function and be involved in tumour development. This review discusses how the role of sTn in cancer development and tumour cell invasiveness might be organ specific and occur through different mechanisms depending on each cancer type or subtype. As the sTn-antigen is expressed early in carcinogenesis targeting sTn in cancer may enable the targeting of tumours from the earliest stage. |
topic |
sialyl-Tn cancer O-glycans ST6GalNAc1 COSMC glycosylation |
url |
http://www.mdpi.com/1422-0067/17/3/275 |
work_keys_str_mv |
AT jennifermunkley theroleofsialyltnincancer AT jennifermunkley roleofsialyltnincancer |
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