The quaternary architecture of RARβ–RXRα heterodimer facilitates domain–domain signal transmission

The quaternary architecture of RARβ–RXRα heterodimer facilitates domain–domain signal transmission

Nuclear receptors (NR) are multidomain proteins, which makes their crystallization challenging. Here the authors present the crystal structure of the retinoic acid receptor β–retinoic X receptor α (RARβ–RXRα) heterodimer bound to DNA, ligands and coactivator peptides, which shows that NR quaternary...

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Main Authors: Vikas Chandra, Dalei Wu, Sheng Li, Nalini Potluri, Youngchang Kim, Fraydoon Rastinejad
Format: Article
Language:English
Published: Nature Publishing Group 2017-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00981-y
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spelling doaj-a6df162dc85447f4af921752869d12fa2021-05-11T07:25:19ZengNature Publishing GroupNature Communications2041-17232017-10-01811910.1038/s41467-017-00981-yThe quaternary architecture of RARβ–RXRα heterodimer facilitates domain–domain signal transmissionVikas Chandra0Dalei Wu1Sheng Li2Nalini Potluri3Youngchang Kim4Fraydoon Rastinejad5Integrative Metabolism Program, Sanford Burnham Prebys Medical Discovery InstituteIntegrative Metabolism Program, Sanford Burnham Prebys Medical Discovery InstituteDepartment of Medicine and UCSD DXMS Proteomics Resource, University of California, San DiegoIntegrative Metabolism Program, Sanford Burnham Prebys Medical Discovery InstituteStructural Biology Center, Biosciences Division, Argonne National LaboratoryIntegrative Metabolism Program, Sanford Burnham Prebys Medical Discovery InstituteNuclear receptors (NR) are multidomain proteins, which makes their crystallization challenging. Here the authors present the crystal structure of the retinoic acid receptor β–retinoic X receptor α (RARβ–RXRα) heterodimer bound to DNA, ligands and coactivator peptides, which shows that NR quaternary architectures are variable.https://doi.org/10.1038/s41467-017-00981-y
collection DOAJ
language English
format Article
sources DOAJ
author Vikas Chandra
Dalei Wu
Sheng Li
Nalini Potluri
Youngchang Kim
Fraydoon Rastinejad
spellingShingle Vikas Chandra
Dalei Wu
Sheng Li
Nalini Potluri
Youngchang Kim
Fraydoon Rastinejad
The quaternary architecture of RARβ–RXRα heterodimer facilitates domain–domain signal transmission
Nature Communications
author_facet Vikas Chandra
Dalei Wu
Sheng Li
Nalini Potluri
Youngchang Kim
Fraydoon Rastinejad
author_sort Vikas Chandra
title The quaternary architecture of RARβ–RXRα heterodimer facilitates domain–domain signal transmission
title_short The quaternary architecture of RARβ–RXRα heterodimer facilitates domain–domain signal transmission
title_full The quaternary architecture of RARβ–RXRα heterodimer facilitates domain–domain signal transmission
title_fullStr The quaternary architecture of RARβ–RXRα heterodimer facilitates domain–domain signal transmission
title_full_unstemmed The quaternary architecture of RARβ–RXRα heterodimer facilitates domain–domain signal transmission
title_sort quaternary architecture of rarβ–rxrα heterodimer facilitates domain–domain signal transmission
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-10-01
description Nuclear receptors (NR) are multidomain proteins, which makes their crystallization challenging. Here the authors present the crystal structure of the retinoic acid receptor β–retinoic X receptor α (RARβ–RXRα) heterodimer bound to DNA, ligands and coactivator peptides, which shows that NR quaternary architectures are variable.
url https://doi.org/10.1038/s41467-017-00981-y
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