Electroacupuncture Plus Auricular Acupressure for Chemotherapy-Associated Insomnia in Breast Cancer Patients: A Pilot Randomized Controlled Trial
Objective: Chemotherapy-associated insomnia is a highly prevalent complaint in breast cancer patients. This study was undertaken to evaluate the safety, feasibility, and preliminary effectiveness of electroacupuncture plus auricular acupressure for chemotherapy-associated insomnia in patients with b...
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doaj-a6e336fc4ab04350af7e82e6769501e32021-05-26T22:33:29ZengSAGE PublishingIntegrative Cancer Therapies1534-73541552-695X2021-05-012010.1177/15347354211019103Electroacupuncture Plus Auricular Acupressure for Chemotherapy-Associated Insomnia in Breast Cancer Patients: A Pilot Randomized Controlled TrialJialing Zhang M.Med0Zongshi Qin M.Med1Tsz Him So MBBS, BChinMed2Haiyong Chen PhD3Wing Lok Lam PhD4Lo Lo Yam B.Med5Pui Yan Chan BSocSc6Lixing Lao PhD7Zhang-Jin Zhang PhD8School of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, ChinaSchool of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, ChinaDepartment of Clinical Oncology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, ChinaSchool of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, ChinaSchool of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, ChinaSchool of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, ChinaSchool of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, ChinaVirginia University of Integrative Medicine, Fairfax, VA, USADepartment of Chinese Medicine, The University of Hong Kong-Shenzhen Hospital (HKU-SZH), Shenzhen, Guangdong, ChinaObjective: Chemotherapy-associated insomnia is a highly prevalent complaint in breast cancer patients. This study was undertaken to evaluate the safety, feasibility, and preliminary effectiveness of electroacupuncture plus auricular acupressure for chemotherapy-associated insomnia in patients with breast cancer. Materials and Methods: In this randomized, wait-list controlled trial, thirty breast cancer patients under or post chemotherapy with insomnia were randomly allocated to the acupuncture or wait-list control group. Participants in acupuncture group received electroacupuncture plus auricular acupressure treatment twice weekly for 6 weeks. Participants in wait-list group received the same regimen of treatment after 6-week of waiting period. Insomnia Severity Index (ISI) served as the primary outcome measurement. Secondary outcomes were sleep parameters recorded with sleep diary and actiwatch, as well as the scores of Pittsburgh Sleep Quality Index (PSQI), Hospital Anxiety and Depression Scale (HADS), and Functional Assessment of Cancer Therapy-Breast Cancer (FACT-B). Results: Twenty-eight participants completed study (13 in the acupuncture group vs 15 in the wait-list control group). At week-6 post-intervention, ISI score change from baseline showed significant between-group difference favoring acupuncture group of −2.9 points (95% CI: −5.2 to −0.6, P = .014). The acupuncture group showed greater improvements in the total sleep time recorded by sleep diary ( P = .026), scores of PSQI ( P = .012), HADS-depression ( P = .020), and FACT-B ( P < .001) compared with the control group. Improvements were maintained at week-10 and week-14 follow-ups. Conclusions: Acupuncture is safe, feasible, and effective for chemotherapy-associated insomnia in breast cancer patients under or post chemotherapy. A larger sample size randomized clinical trial is warranted to confirm the present findings. Clinical Trial Registration: NCT03762694.https://doi.org/10.1177/15347354211019103 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jialing Zhang M.Med Zongshi Qin M.Med Tsz Him So MBBS, BChinMed Haiyong Chen PhD Wing Lok Lam PhD Lo Lo Yam B.Med Pui Yan Chan BSocSc Lixing Lao PhD Zhang-Jin Zhang PhD |
spellingShingle |
Jialing Zhang M.Med Zongshi Qin M.Med Tsz Him So MBBS, BChinMed Haiyong Chen PhD Wing Lok Lam PhD Lo Lo Yam B.Med Pui Yan Chan BSocSc Lixing Lao PhD Zhang-Jin Zhang PhD Electroacupuncture Plus Auricular Acupressure for Chemotherapy-Associated Insomnia in Breast Cancer Patients: A Pilot Randomized Controlled Trial Integrative Cancer Therapies |
author_facet |
Jialing Zhang M.Med Zongshi Qin M.Med Tsz Him So MBBS, BChinMed Haiyong Chen PhD Wing Lok Lam PhD Lo Lo Yam B.Med Pui Yan Chan BSocSc Lixing Lao PhD Zhang-Jin Zhang PhD |
author_sort |
Jialing Zhang M.Med |
title |
Electroacupuncture Plus Auricular Acupressure for Chemotherapy-Associated Insomnia in Breast Cancer Patients: A Pilot Randomized Controlled Trial |
title_short |
Electroacupuncture Plus Auricular Acupressure for Chemotherapy-Associated Insomnia in Breast Cancer Patients: A Pilot Randomized Controlled Trial |
title_full |
Electroacupuncture Plus Auricular Acupressure for Chemotherapy-Associated Insomnia in Breast Cancer Patients: A Pilot Randomized Controlled Trial |
title_fullStr |
Electroacupuncture Plus Auricular Acupressure for Chemotherapy-Associated Insomnia in Breast Cancer Patients: A Pilot Randomized Controlled Trial |
title_full_unstemmed |
Electroacupuncture Plus Auricular Acupressure for Chemotherapy-Associated Insomnia in Breast Cancer Patients: A Pilot Randomized Controlled Trial |
title_sort |
electroacupuncture plus auricular acupressure for chemotherapy-associated insomnia in breast cancer patients: a pilot randomized controlled trial |
publisher |
SAGE Publishing |
series |
Integrative Cancer Therapies |
issn |
1534-7354 1552-695X |
publishDate |
2021-05-01 |
description |
Objective: Chemotherapy-associated insomnia is a highly prevalent complaint in breast cancer patients. This study was undertaken to evaluate the safety, feasibility, and preliminary effectiveness of electroacupuncture plus auricular acupressure for chemotherapy-associated insomnia in patients with breast cancer. Materials and Methods: In this randomized, wait-list controlled trial, thirty breast cancer patients under or post chemotherapy with insomnia were randomly allocated to the acupuncture or wait-list control group. Participants in acupuncture group received electroacupuncture plus auricular acupressure treatment twice weekly for 6 weeks. Participants in wait-list group received the same regimen of treatment after 6-week of waiting period. Insomnia Severity Index (ISI) served as the primary outcome measurement. Secondary outcomes were sleep parameters recorded with sleep diary and actiwatch, as well as the scores of Pittsburgh Sleep Quality Index (PSQI), Hospital Anxiety and Depression Scale (HADS), and Functional Assessment of Cancer Therapy-Breast Cancer (FACT-B). Results: Twenty-eight participants completed study (13 in the acupuncture group vs 15 in the wait-list control group). At week-6 post-intervention, ISI score change from baseline showed significant between-group difference favoring acupuncture group of −2.9 points (95% CI: −5.2 to −0.6, P = .014). The acupuncture group showed greater improvements in the total sleep time recorded by sleep diary ( P = .026), scores of PSQI ( P = .012), HADS-depression ( P = .020), and FACT-B ( P < .001) compared with the control group. Improvements were maintained at week-10 and week-14 follow-ups. Conclusions: Acupuncture is safe, feasible, and effective for chemotherapy-associated insomnia in breast cancer patients under or post chemotherapy. A larger sample size randomized clinical trial is warranted to confirm the present findings. Clinical Trial Registration: NCT03762694. |
url |
https://doi.org/10.1177/15347354211019103 |
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