Comparison of QuantiFERON-TB gold in tube test versus tuberculin skin test for screening of latent tuberculosis infection in Saudi Arabia: A population-based study
Objectives: To compare QuantiFERON-TB gold in tube (QFT-GIT) test with tuberculin skin test (TST) in detecting latent tuberculosis infection (LTBI) among a general population in Saudi Arabia. Methods: A population-based cross-sectional study was conducted between July 2010 and March 2013 among indiv...
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doaj-a6e90abb699c4460ad3c2087d43016342020-11-24T20:47:21ZengWolters Kluwer Medknow PublicationsAnnals of Thoracic Medicine1817-17371998-35572016-01-0111319720110.4103/1817-1737.185759Comparison of QuantiFERON-TB gold in tube test versus tuberculin skin test for screening of latent tuberculosis infection in Saudi Arabia: A population-based studyHanan H BalkhyKamel El BeltagyAiman El-SaedBadr AljasirAbdulhakeem AlthaqafiAdel F AlothmanMohammad AlshalaanHamdan Al-JahdaliObjectives: To compare QuantiFERON-TB gold in tube (QFT-GIT) test with tuberculin skin test (TST) in detecting latent tuberculosis infection (LTBI) among a general population in Saudi Arabia. Methods: A population-based cross-sectional study was conducted between July 2010 and March 2013 among individuals randomly selected from the list of those receiving care at primary healthcare centers in three provinces of Saudi Arabia; Central, Western, and Eastern provinces. Those younger than 5 years, immunocompromised, had a current or previous history of active TB, LTBI, or who were receiving anti-TB medications were excluded. Informed consent was obtained before the study questionnaire was completed. Participants were then evaluated for LTBI using QFT-GIT test followed immediately by TST. Results: Of the 1369 subjects included in the final analysis, QFT-GIT was positive in 124 (9.1%) and TST was positive in 127 (9.3%). Positive concordance was observed in 49 (3.6%) subjects while negative concordance was observed in 1167 (85.2%) subjects. The overall agreement between the two tests was 88.8% with a significant kappa (κ) test (κ = 0.332,P< 0.001). Concordance was significantly higher in younger age, female gender, single status, students, primary education, living in middle-sized families, and never smoked. Conclusions: The overall agreement of TST and QFT-GIT for the detection of LTBI among a Saudi general population was 88.8%. QFT-GIT is probably comparable to TST for detecting LTBI in an intermediate TB burden country with high at birth bacille calmette guerin vaccination coverage. Further prospective studies are needed to compare the ability of both tests to predict TB disease.http://www.thoracicmedicine.org/article.asp?issn=1817-1737;year=2016;volume=11;issue=3;spage=197;epage=201;aulast=BalkhyLatent mycobacterium tuberculosis infectionQuantiFERON-TB gold in tube testSaudi Arabiatuberculin skin test |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hanan H Balkhy Kamel El Beltagy Aiman El-Saed Badr Aljasir Abdulhakeem Althaqafi Adel F Alothman Mohammad Alshalaan Hamdan Al-Jahdali |
spellingShingle |
Hanan H Balkhy Kamel El Beltagy Aiman El-Saed Badr Aljasir Abdulhakeem Althaqafi Adel F Alothman Mohammad Alshalaan Hamdan Al-Jahdali Comparison of QuantiFERON-TB gold in tube test versus tuberculin skin test for screening of latent tuberculosis infection in Saudi Arabia: A population-based study Annals of Thoracic Medicine Latent mycobacterium tuberculosis infection QuantiFERON-TB gold in tube test Saudi Arabia tuberculin skin test |
author_facet |
Hanan H Balkhy Kamel El Beltagy Aiman El-Saed Badr Aljasir Abdulhakeem Althaqafi Adel F Alothman Mohammad Alshalaan Hamdan Al-Jahdali |
author_sort |
Hanan H Balkhy |
title |
Comparison of QuantiFERON-TB gold in tube test versus tuberculin skin test for screening of latent tuberculosis infection in Saudi Arabia: A population-based study |
title_short |
Comparison of QuantiFERON-TB gold in tube test versus tuberculin skin test for screening of latent tuberculosis infection in Saudi Arabia: A population-based study |
title_full |
Comparison of QuantiFERON-TB gold in tube test versus tuberculin skin test for screening of latent tuberculosis infection in Saudi Arabia: A population-based study |
title_fullStr |
Comparison of QuantiFERON-TB gold in tube test versus tuberculin skin test for screening of latent tuberculosis infection in Saudi Arabia: A population-based study |
title_full_unstemmed |
Comparison of QuantiFERON-TB gold in tube test versus tuberculin skin test for screening of latent tuberculosis infection in Saudi Arabia: A population-based study |
title_sort |
comparison of quantiferon-tb gold in tube test versus tuberculin skin test for screening of latent tuberculosis infection in saudi arabia: a population-based study |
publisher |
Wolters Kluwer Medknow Publications |
series |
Annals of Thoracic Medicine |
issn |
1817-1737 1998-3557 |
publishDate |
2016-01-01 |
description |
Objectives: To compare QuantiFERON-TB gold in tube (QFT-GIT) test with tuberculin skin test (TST) in detecting latent tuberculosis infection (LTBI) among a general population in Saudi Arabia.
Methods: A population-based cross-sectional study was conducted between July 2010 and March 2013 among individuals randomly selected from the list of those receiving care at primary healthcare centers in three provinces of Saudi Arabia; Central, Western, and Eastern provinces. Those younger than 5 years, immunocompromised, had a current or previous history of active TB, LTBI, or who were receiving anti-TB medications were excluded. Informed consent was obtained before the study questionnaire was completed. Participants were then evaluated for LTBI using QFT-GIT test followed immediately by TST.
Results: Of the 1369 subjects included in the final analysis, QFT-GIT was positive in 124 (9.1%) and TST was positive in 127 (9.3%). Positive concordance was observed in 49 (3.6%) subjects while negative concordance was observed in 1167 (85.2%) subjects. The overall agreement between the two tests was 88.8% with a significant kappa (κ) test (κ = 0.332,P< 0.001). Concordance was significantly higher in younger age, female gender, single status, students, primary education, living in middle-sized families, and never smoked.
Conclusions: The overall agreement of TST and QFT-GIT for the detection of LTBI among a Saudi general population was 88.8%. QFT-GIT is probably comparable to TST for detecting LTBI in an intermediate TB burden country with high at birth bacille calmette guerin vaccination coverage. Further prospective studies are needed to compare the ability of both tests to predict TB disease. |
topic |
Latent mycobacterium tuberculosis infection QuantiFERON-TB gold in tube test Saudi Arabia tuberculin skin test |
url |
http://www.thoracicmedicine.org/article.asp?issn=1817-1737;year=2016;volume=11;issue=3;spage=197;epage=201;aulast=Balkhy |
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