Thyrotropin Receptor Epitope and Human Leukocyte Antigen in Graves’ disease

Thyrotropin Receptor Epitope and Human Leukocyte Antigen in Graves’ disease

Graves’ disease (GD) is an organ-specific autoimmune disease, and Thyrotropin (TSH) receptor (TSHR) is a major autoantigen in this condition. Since the extracellular domain of human TSHR (TSHR-ECD) is shed into the circulation, TSHR-ECD is a preferentially immunogenic portion of TSHR. Both genetic f...

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Bibliographic Details
Main Authors: Hidefumi Inaba, Leslie J De Groot, Takashi Akamizu
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-08-01
Series:Frontiers in Endocrinology
Subjects:
HLA
TSH receptor
epitope
Graves’ disease
anti-TSHR-antibody
Online Access:http://journal.frontiersin.org/Journal/10.3389/fendo.2016.00120/full

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