The platelet receptor CLEC-2 blocks neutrophil mediated hepatic recovery in acetaminophen induced acute liver failure

The molecular mechanisms that drive irreversible acute liver failure remain poorly characterized. Here, the authors show that the recently discovered platelet receptor CLEC-2 (C-type lectin-like receptor) perpetuates and worsens liver damage during acute liver injury by blocking restorative neutroph...

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Main Authors:	Abhishek Chauhan, Lozan Sheriff, Mohammed T. Hussain, Gwilym J. Webb, Daniel A. Patten, Emma L. Shepherd, Robert Shaw, Christopher J. Weston, Debashis Haldar, Samuel Bourke, Rajan Bhandari, Stephanie Watson, David H. Adams, Steve P. Watson, Patricia F. Lalor
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-04-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-15584-3

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spelling	doaj-a6f8dbdcb34b42c0a82ada447cf8eac92021-05-11T08:31:13ZengNature Publishing GroupNature Communications2041-17232020-04-0111111210.1038/s41467-020-15584-3The platelet receptor CLEC-2 blocks neutrophil mediated hepatic recovery in acetaminophen induced acute liver failureAbhishek Chauhan0Lozan Sheriff1Mohammed T. Hussain2Gwilym J. Webb3Daniel A. Patten4Emma L. Shepherd5Robert Shaw6Christopher J. Weston7Debashis Haldar8Samuel Bourke9Rajan Bhandari10Stephanie Watson11David H. Adams12Steve P. Watson13Patricia F. Lalor14Centre for Liver and Gastrointestinal Research, Institute of Immunology and Inflammation, and National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre, The Medical School, University of BirminghamCentre for Liver and Gastrointestinal Research, Institute of Immunology and Inflammation, and National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre, The Medical School, University of BirminghamCentre for Liver and Gastrointestinal Research, Institute of Immunology and Inflammation, and National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre, The Medical School, University of BirminghamCentre for Liver and Gastrointestinal Research, Institute of Immunology and Inflammation, and National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre, The Medical School, University of BirminghamCentre for Liver and Gastrointestinal Research, Institute of Immunology and Inflammation, and National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre, The Medical School, University of BirminghamCentre for Liver and Gastrointestinal Research, Institute of Immunology and Inflammation, and National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre, The Medical School, University of BirminghamTechnology Hub, College of Medical and Dental Sciences, University of BirminghamCentre for Liver and Gastrointestinal Research, Institute of Immunology and Inflammation, and National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre, The Medical School, University of BirminghamCentre for Liver and Gastrointestinal Research, Institute of Immunology and Inflammation, and National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre, The Medical School, University of BirminghamCentre for Liver and Gastrointestinal Research, Institute of Immunology and Inflammation, and National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre, The Medical School, University of BirminghamCentre for Liver and Gastrointestinal Research, Institute of Immunology and Inflammation, and National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre, The Medical School, University of BirminghamInstitute of Cardiovascular Sciences, The Medical School, University of BirminghamCentre for Liver and Gastrointestinal Research, Institute of Immunology and Inflammation, and National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre, The Medical School, University of BirminghamInstitute of Cardiovascular Sciences, The Medical School, University of BirminghamCentre for Liver and Gastrointestinal Research, Institute of Immunology and Inflammation, and National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre, The Medical School, University of BirminghamThe molecular mechanisms that drive irreversible acute liver failure remain poorly characterized. Here, the authors show that the recently discovered platelet receptor CLEC-2 (C-type lectin-like receptor) perpetuates and worsens liver damage during acute liver injury by blocking restorative neutrophil driven inflammation.https://doi.org/10.1038/s41467-020-15584-3
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Abhishek Chauhan Lozan Sheriff Mohammed T. Hussain Gwilym J. Webb Daniel A. Patten Emma L. Shepherd Robert Shaw Christopher J. Weston Debashis Haldar Samuel Bourke Rajan Bhandari Stephanie Watson David H. Adams Steve P. Watson Patricia F. Lalor
spellingShingle	Abhishek Chauhan Lozan Sheriff Mohammed T. Hussain Gwilym J. Webb Daniel A. Patten Emma L. Shepherd Robert Shaw Christopher J. Weston Debashis Haldar Samuel Bourke Rajan Bhandari Stephanie Watson David H. Adams Steve P. Watson Patricia F. Lalor The platelet receptor CLEC-2 blocks neutrophil mediated hepatic recovery in acetaminophen induced acute liver failure Nature Communications
author_facet	Abhishek Chauhan Lozan Sheriff Mohammed T. Hussain Gwilym J. Webb Daniel A. Patten Emma L. Shepherd Robert Shaw Christopher J. Weston Debashis Haldar Samuel Bourke Rajan Bhandari Stephanie Watson David H. Adams Steve P. Watson Patricia F. Lalor
author_sort	Abhishek Chauhan
title	The platelet receptor CLEC-2 blocks neutrophil mediated hepatic recovery in acetaminophen induced acute liver failure
title_short	The platelet receptor CLEC-2 blocks neutrophil mediated hepatic recovery in acetaminophen induced acute liver failure
title_full	The platelet receptor CLEC-2 blocks neutrophil mediated hepatic recovery in acetaminophen induced acute liver failure
title_fullStr	The platelet receptor CLEC-2 blocks neutrophil mediated hepatic recovery in acetaminophen induced acute liver failure
title_full_unstemmed	The platelet receptor CLEC-2 blocks neutrophil mediated hepatic recovery in acetaminophen induced acute liver failure
title_sort	platelet receptor clec-2 blocks neutrophil mediated hepatic recovery in acetaminophen induced acute liver failure
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-04-01
description	The molecular mechanisms that drive irreversible acute liver failure remain poorly characterized. Here, the authors show that the recently discovered platelet receptor CLEC-2 (C-type lectin-like receptor) perpetuates and worsens liver damage during acute liver injury by blocking restorative neutrophil driven inflammation.
url	https://doi.org/10.1038/s41467-020-15584-3
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The platelet receptor CLEC-2 blocks neutrophil mediated hepatic recovery in acetaminophen induced acute liver failure

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