Pharmacologic Prophylaxis and Treatment of Venous Thromboembolism after Knee Arthroplasty

The objective of this study was to evaluate the efficacy of unfractionated heparin, warfarin and low molecular weight heparins (LMWH) used for the prevention of venous thromboembolism in arthroplastic surgery of the knee joint. Methods: In this prospective study from August 2002 to November 2004, 60...

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Main Authors: Jamal S Shawabkeh, Malek M Ghnaimat, Ammar M Hijazi
Format: Article
Language:English
Published: Sultan Qaboos University 2007-04-01
Series:Sultan Qaboos University Medical Journal
Subjects:
Online Access:https://journals.squ.edu.om/index.php/squmj/article/view/1277
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spelling doaj-a6fe23444fcb4ad2900bf8c40f7adc2e2020-11-25T02:55:14ZengSultan Qaboos UniversitySultan Qaboos University Medical Journal 2075-051X2075-05282007-04-017147501205Pharmacologic Prophylaxis and Treatment of Venous Thromboembolism after Knee ArthroplastyJamal S Shawabkeh0Malek M Ghnaimat1Ammar M Hijazi2Orthopedic Department, Royal Jordanian Medical Services, P O Box 517, Amman 11118, JordanOrthopedic Department, Royal Jordanian Medical Services, P O Box 517, Amman 11118, JordanOrthopedic Department, Royal Jordanian Medical Services, P O Box 517, Amman 11118, JordanThe objective of this study was to evaluate the efficacy of unfractionated heparin, warfarin and low molecular weight heparins (LMWH) used for the prevention of venous thromboembolism in arthroplastic surgery of the knee joint. Methods: In this prospective study from August 2002 to November 2004, 60 patients were included and divided into three groups with equal numbers, with each group receiving different treatment protocol. Postoperatively, the occurrence of symptomatic deep vein thrombosis (DVT) or pulmonary embolism (PE) was recorded during the first 30 days after surgery and at a routine follow-up visit. Results: A significantly lower prevalence of DVT and PE was found in patients using warfarin and LMWH as prophylaxis in comparison with patients using unfractionated heparin. Conclusion: Warfarin and low molecular weight heparins are more beneficial and effective than unfractionated heparin for DVT and PE prophylaxis in arthroplastic knee surgeries.https://journals.squ.edu.om/index.php/squmj/article/view/1277arthroplasty, deep vein thrombosis (dvt), prophylaxis, low molecular weight heparin, warfarin.
collection DOAJ
language English
format Article
sources DOAJ
author Jamal S Shawabkeh
Malek M Ghnaimat
Ammar M Hijazi
spellingShingle Jamal S Shawabkeh
Malek M Ghnaimat
Ammar M Hijazi
Pharmacologic Prophylaxis and Treatment of Venous Thromboembolism after Knee Arthroplasty
Sultan Qaboos University Medical Journal
arthroplasty, deep vein thrombosis (dvt), prophylaxis, low molecular weight heparin, warfarin.
author_facet Jamal S Shawabkeh
Malek M Ghnaimat
Ammar M Hijazi
author_sort Jamal S Shawabkeh
title Pharmacologic Prophylaxis and Treatment of Venous Thromboembolism after Knee Arthroplasty
title_short Pharmacologic Prophylaxis and Treatment of Venous Thromboembolism after Knee Arthroplasty
title_full Pharmacologic Prophylaxis and Treatment of Venous Thromboembolism after Knee Arthroplasty
title_fullStr Pharmacologic Prophylaxis and Treatment of Venous Thromboembolism after Knee Arthroplasty
title_full_unstemmed Pharmacologic Prophylaxis and Treatment of Venous Thromboembolism after Knee Arthroplasty
title_sort pharmacologic prophylaxis and treatment of venous thromboembolism after knee arthroplasty
publisher Sultan Qaboos University
series Sultan Qaboos University Medical Journal
issn 2075-051X
2075-0528
publishDate 2007-04-01
description The objective of this study was to evaluate the efficacy of unfractionated heparin, warfarin and low molecular weight heparins (LMWH) used for the prevention of venous thromboembolism in arthroplastic surgery of the knee joint. Methods: In this prospective study from August 2002 to November 2004, 60 patients were included and divided into three groups with equal numbers, with each group receiving different treatment protocol. Postoperatively, the occurrence of symptomatic deep vein thrombosis (DVT) or pulmonary embolism (PE) was recorded during the first 30 days after surgery and at a routine follow-up visit. Results: A significantly lower prevalence of DVT and PE was found in patients using warfarin and LMWH as prophylaxis in comparison with patients using unfractionated heparin. Conclusion: Warfarin and low molecular weight heparins are more beneficial and effective than unfractionated heparin for DVT and PE prophylaxis in arthroplastic knee surgeries.
topic arthroplasty, deep vein thrombosis (dvt), prophylaxis, low molecular weight heparin, warfarin.
url https://journals.squ.edu.om/index.php/squmj/article/view/1277
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AT malekmghnaimat pharmacologicprophylaxisandtreatmentofvenousthromboembolismafterkneearthroplasty
AT ammarmhijazi pharmacologicprophylaxisandtreatmentofvenousthromboembolismafterkneearthroplasty
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