Novel CBG Derivatives Can Reduce Inflammation, Pain and Obesity
Interest in CBG (cannabigerol) has been growing in the past few years, due to its anti-inflammatory properties and other therapeutic benefits. Here we report the synthesis of three new CBG derivatives (HUM-223, HUM-233 and HUM-234) and show them to possess anti-inflammatory and analgesic properties....
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doaj-a6ffb15a4ba14101a91c716db021ac582021-09-26T00:46:37ZengMDPI AGMolecules1420-30492021-09-01265601560110.3390/molecules26185601Novel CBG Derivatives Can Reduce Inflammation, Pain and ObesityNatalya M. Kogan0Yarden Lavi1Louise M. Topping2Richard. O. Williams3Fiona E. McCann4Zhanna Yekhtin5Marc Feldmann6Ruth Gallily7Raphael Mechoulam8Medical Faculty, Institute for Drug Research, Hebrew University, Jerusalem 91120, IsraelMedical Faculty, Institute for Drug Research, Hebrew University, Jerusalem 91120, IsraelKennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UKKennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK180 Life Sciences, Menlo Park, CA 94025, USALautenberg Center of Immunology and Cancer Research, The Hebrew University of Jerusalem, Jerusalem 91120, IsraelKennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UKLautenberg Center of Immunology and Cancer Research, The Hebrew University of Jerusalem, Jerusalem 91120, IsraelMedical Faculty, Institute for Drug Research, Hebrew University, Jerusalem 91120, IsraelInterest in CBG (cannabigerol) has been growing in the past few years, due to its anti-inflammatory properties and other therapeutic benefits. Here we report the synthesis of three new CBG derivatives (HUM-223, HUM-233 and HUM-234) and show them to possess anti-inflammatory and analgesic properties. In addition, unlike CBG, HUM-234 also prevents obesity in mice fed a high-fat diet (HFD). The metabolic state of the treated mice on HFD is significantly better than that of vehicle-treated mice, and their liver slices show significantly less steatosis than untreated HFD or CBG-treated ones from HFD mice. We believe that HUM-223, HUM-233 and HUM-234 have the potential for development as novel drug candidates for the treatment of inflammatory conditions, and in the case of HUM-234, potentially for obesity where there is a huge unmet need.https://www.mdpi.com/1420-3049/26/18/5601cannabinoidcannabigerolanti-inflammatoryobesity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Natalya M. Kogan Yarden Lavi Louise M. Topping Richard. O. Williams Fiona E. McCann Zhanna Yekhtin Marc Feldmann Ruth Gallily Raphael Mechoulam |
spellingShingle |
Natalya M. Kogan Yarden Lavi Louise M. Topping Richard. O. Williams Fiona E. McCann Zhanna Yekhtin Marc Feldmann Ruth Gallily Raphael Mechoulam Novel CBG Derivatives Can Reduce Inflammation, Pain and Obesity Molecules cannabinoid cannabigerol anti-inflammatory obesity |
author_facet |
Natalya M. Kogan Yarden Lavi Louise M. Topping Richard. O. Williams Fiona E. McCann Zhanna Yekhtin Marc Feldmann Ruth Gallily Raphael Mechoulam |
author_sort |
Natalya M. Kogan |
title |
Novel CBG Derivatives Can Reduce Inflammation, Pain and Obesity |
title_short |
Novel CBG Derivatives Can Reduce Inflammation, Pain and Obesity |
title_full |
Novel CBG Derivatives Can Reduce Inflammation, Pain and Obesity |
title_fullStr |
Novel CBG Derivatives Can Reduce Inflammation, Pain and Obesity |
title_full_unstemmed |
Novel CBG Derivatives Can Reduce Inflammation, Pain and Obesity |
title_sort |
novel cbg derivatives can reduce inflammation, pain and obesity |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2021-09-01 |
description |
Interest in CBG (cannabigerol) has been growing in the past few years, due to its anti-inflammatory properties and other therapeutic benefits. Here we report the synthesis of three new CBG derivatives (HUM-223, HUM-233 and HUM-234) and show them to possess anti-inflammatory and analgesic properties. In addition, unlike CBG, HUM-234 also prevents obesity in mice fed a high-fat diet (HFD). The metabolic state of the treated mice on HFD is significantly better than that of vehicle-treated mice, and their liver slices show significantly less steatosis than untreated HFD or CBG-treated ones from HFD mice. We believe that HUM-223, HUM-233 and HUM-234 have the potential for development as novel drug candidates for the treatment of inflammatory conditions, and in the case of HUM-234, potentially for obesity where there is a huge unmet need. |
topic |
cannabinoid cannabigerol anti-inflammatory obesity |
url |
https://www.mdpi.com/1420-3049/26/18/5601 |
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