Novel CBG Derivatives Can Reduce Inflammation, Pain and Obesity

Interest in CBG (cannabigerol) has been growing in the past few years, due to its anti-inflammatory properties and other therapeutic benefits. Here we report the synthesis of three new CBG derivatives (HUM-223, HUM-233 and HUM-234) and show them to possess anti-inflammatory and analgesic properties....

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Main Authors:	Natalya M. Kogan, Yarden Lavi, Louise M. Topping, Richard. O. Williams, Fiona E. McCann, Zhanna Yekhtin, Marc Feldmann, Ruth Gallily, Raphael Mechoulam
Format:	Article
Language:	English
Published:	MDPI AG 2021-09-01
Series:	Molecules
Subjects:	cannabinoid cannabigerol anti-inflammatory obesity
Online Access:	https://www.mdpi.com/1420-3049/26/18/5601

id	doaj-a6ffb15a4ba14101a91c716db021ac58
record_format	Article
spelling	doaj-a6ffb15a4ba14101a91c716db021ac582021-09-26T00:46:37ZengMDPI AGMolecules1420-30492021-09-01265601560110.3390/molecules26185601Novel CBG Derivatives Can Reduce Inflammation, Pain and ObesityNatalya M. Kogan0Yarden Lavi1Louise M. Topping2Richard. O. Williams3Fiona E. McCann4Zhanna Yekhtin5Marc Feldmann6Ruth Gallily7Raphael Mechoulam8Medical Faculty, Institute for Drug Research, Hebrew University, Jerusalem 91120, IsraelMedical Faculty, Institute for Drug Research, Hebrew University, Jerusalem 91120, IsraelKennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UKKennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK180 Life Sciences, Menlo Park, CA 94025, USALautenberg Center of Immunology and Cancer Research, The Hebrew University of Jerusalem, Jerusalem 91120, IsraelKennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UKLautenberg Center of Immunology and Cancer Research, The Hebrew University of Jerusalem, Jerusalem 91120, IsraelMedical Faculty, Institute for Drug Research, Hebrew University, Jerusalem 91120, IsraelInterest in CBG (cannabigerol) has been growing in the past few years, due to its anti-inflammatory properties and other therapeutic benefits. Here we report the synthesis of three new CBG derivatives (HUM-223, HUM-233 and HUM-234) and show them to possess anti-inflammatory and analgesic properties. In addition, unlike CBG, HUM-234 also prevents obesity in mice fed a high-fat diet (HFD). The metabolic state of the treated mice on HFD is significantly better than that of vehicle-treated mice, and their liver slices show significantly less steatosis than untreated HFD or CBG-treated ones from HFD mice. We believe that HUM-223, HUM-233 and HUM-234 have the potential for development as novel drug candidates for the treatment of inflammatory conditions, and in the case of HUM-234, potentially for obesity where there is a huge unmet need.https://www.mdpi.com/1420-3049/26/18/5601cannabinoidcannabigerolanti-inflammatoryobesity
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Natalya M. Kogan Yarden Lavi Louise M. Topping Richard. O. Williams Fiona E. McCann Zhanna Yekhtin Marc Feldmann Ruth Gallily Raphael Mechoulam
spellingShingle	Natalya M. Kogan Yarden Lavi Louise M. Topping Richard. O. Williams Fiona E. McCann Zhanna Yekhtin Marc Feldmann Ruth Gallily Raphael Mechoulam Novel CBG Derivatives Can Reduce Inflammation, Pain and Obesity Molecules cannabinoid cannabigerol anti-inflammatory obesity
author_facet	Natalya M. Kogan Yarden Lavi Louise M. Topping Richard. O. Williams Fiona E. McCann Zhanna Yekhtin Marc Feldmann Ruth Gallily Raphael Mechoulam
author_sort	Natalya M. Kogan
title	Novel CBG Derivatives Can Reduce Inflammation, Pain and Obesity
title_short	Novel CBG Derivatives Can Reduce Inflammation, Pain and Obesity
title_full	Novel CBG Derivatives Can Reduce Inflammation, Pain and Obesity
title_fullStr	Novel CBG Derivatives Can Reduce Inflammation, Pain and Obesity
title_full_unstemmed	Novel CBG Derivatives Can Reduce Inflammation, Pain and Obesity
title_sort	novel cbg derivatives can reduce inflammation, pain and obesity
publisher	MDPI AG
series	Molecules
issn	1420-3049
publishDate	2021-09-01
description	Interest in CBG (cannabigerol) has been growing in the past few years, due to its anti-inflammatory properties and other therapeutic benefits. Here we report the synthesis of three new CBG derivatives (HUM-223, HUM-233 and HUM-234) and show them to possess anti-inflammatory and analgesic properties. In addition, unlike CBG, HUM-234 also prevents obesity in mice fed a high-fat diet (HFD). The metabolic state of the treated mice on HFD is significantly better than that of vehicle-treated mice, and their liver slices show significantly less steatosis than untreated HFD or CBG-treated ones from HFD mice. We believe that HUM-223, HUM-233 and HUM-234 have the potential for development as novel drug candidates for the treatment of inflammatory conditions, and in the case of HUM-234, potentially for obesity where there is a huge unmet need.
topic	cannabinoid cannabigerol anti-inflammatory obesity
url	https://www.mdpi.com/1420-3049/26/18/5601
work_keys_str_mv	AT natalyamkogan novelcbgderivativescanreduceinflammationpainandobesity AT yardenlavi novelcbgderivativescanreduceinflammationpainandobesity AT louisemtopping novelcbgderivativescanreduceinflammationpainandobesity AT richardowilliams novelcbgderivativescanreduceinflammationpainandobesity AT fionaemccann novelcbgderivativescanreduceinflammationpainandobesity AT zhannayekhtin novelcbgderivativescanreduceinflammationpainandobesity AT marcfeldmann novelcbgderivativescanreduceinflammationpainandobesity AT ruthgallily novelcbgderivativescanreduceinflammationpainandobesity AT raphaelmechoulam novelcbgderivativescanreduceinflammationpainandobesity
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Novel CBG Derivatives Can Reduce Inflammation, Pain and Obesity

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