Deep whole-genome sequencing reveals recent selection signatures linked to evolution and disease risk of Japanese

Deep whole-genome sequencing reveals recent selection signatures linked to evolution and disease risk of Japanese

Recent natural selection left signals in human genomes. Here, Okada et al. generate high-depth whole-genome sequence (WGS) data (25.9×) from 2,234 Japanese people of the BioBank Japan Project (BBJ), and identify signals of recent natural selection which overlap variants associated with human traits....

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Main Authors: Yukinori Okada, Yukihide Momozawa, Saori Sakaue, Masahiro Kanai, Kazuyoshi Ishigaki, Masato Akiyama, Toshihiro Kishikawa, Yasumichi Arai, Takashi Sasaki, Kenjiro Kosaki, Makoto Suematsu, Koichi Matsuda, Kazuhiko Yamamoto, Michiaki Kubo, Nobuyoshi Hirose, Yoichiro Kamatani
Format: Article
Language:English
Published: Nature Publishing Group 2018-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03274-0
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spelling doaj-a7100fc58b45430b96a43754e2ef8a432021-05-11T09:54:47ZengNature Publishing GroupNature Communications2041-17232018-04-019111010.1038/s41467-018-03274-0Deep whole-genome sequencing reveals recent selection signatures linked to evolution and disease risk of JapaneseYukinori Okada0Yukihide Momozawa1Saori Sakaue2Masahiro Kanai3Kazuyoshi Ishigaki4Masato Akiyama5Toshihiro Kishikawa6Yasumichi Arai7Takashi Sasaki8Kenjiro Kosaki9Makoto Suematsu10Koichi Matsuda11Kazuhiko Yamamoto12Michiaki Kubo13Nobuyoshi Hirose14Yoichiro Kamatani15Department of Statistical Genetics, Osaka University Graduate School of MedicineLaboratory for Genotyping Development, RIKEN Center for Integrative Medical SciencesDepartment of Statistical Genetics, Osaka University Graduate School of MedicineDepartment of Statistical Genetics, Osaka University Graduate School of MedicineLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical SciencesLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical SciencesDepartment of Statistical Genetics, Osaka University Graduate School of MedicineCenter for Supercentenarian Medical Research, Keio University School of MedicineCenter for Supercentenarian Medical Research, Keio University School of MedicineCenter for Medical Genetics, Keio University School of MedicineDepartment of Biochemistry, Keio University School of MedicineDepartment of Computational Biology and Medical Sciences, Graduate school of Frontier Sciences, The University of TokyoLaboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical SciencesRIKEN Center for Integrative Medical SciencesCenter for Supercentenarian Medical Research, Keio University School of MedicineLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical SciencesRecent natural selection left signals in human genomes. Here, Okada et al. generate high-depth whole-genome sequence (WGS) data (25.9×) from 2,234 Japanese people of the BioBank Japan Project (BBJ), and identify signals of recent natural selection which overlap variants associated with human traits.https://doi.org/10.1038/s41467-018-03274-0
collection DOAJ
language English
format Article
sources DOAJ
author Yukinori Okada
Yukihide Momozawa
Saori Sakaue
Masahiro Kanai
Kazuyoshi Ishigaki
Masato Akiyama
Toshihiro Kishikawa
Yasumichi Arai
Takashi Sasaki
Kenjiro Kosaki
Makoto Suematsu
Koichi Matsuda
Kazuhiko Yamamoto
Michiaki Kubo
Nobuyoshi Hirose
Yoichiro Kamatani
spellingShingle Yukinori Okada
Yukihide Momozawa
Saori Sakaue
Masahiro Kanai
Kazuyoshi Ishigaki
Masato Akiyama
Toshihiro Kishikawa
Yasumichi Arai
Takashi Sasaki
Kenjiro Kosaki
Makoto Suematsu
Koichi Matsuda
Kazuhiko Yamamoto
Michiaki Kubo
Nobuyoshi Hirose
Yoichiro Kamatani
Deep whole-genome sequencing reveals recent selection signatures linked to evolution and disease risk of Japanese
Nature Communications
author_facet Yukinori Okada
Yukihide Momozawa
Saori Sakaue
Masahiro Kanai
Kazuyoshi Ishigaki
Masato Akiyama
Toshihiro Kishikawa
Yasumichi Arai
Takashi Sasaki
Kenjiro Kosaki
Makoto Suematsu
Koichi Matsuda
Kazuhiko Yamamoto
Michiaki Kubo
Nobuyoshi Hirose
Yoichiro Kamatani
author_sort Yukinori Okada
title Deep whole-genome sequencing reveals recent selection signatures linked to evolution and disease risk of Japanese
title_short Deep whole-genome sequencing reveals recent selection signatures linked to evolution and disease risk of Japanese
title_full Deep whole-genome sequencing reveals recent selection signatures linked to evolution and disease risk of Japanese
title_fullStr Deep whole-genome sequencing reveals recent selection signatures linked to evolution and disease risk of Japanese
title_full_unstemmed Deep whole-genome sequencing reveals recent selection signatures linked to evolution and disease risk of Japanese
title_sort deep whole-genome sequencing reveals recent selection signatures linked to evolution and disease risk of japanese
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-04-01
description Recent natural selection left signals in human genomes. Here, Okada et al. generate high-depth whole-genome sequence (WGS) data (25.9×) from 2,234 Japanese people of the BioBank Japan Project (BBJ), and identify signals of recent natural selection which overlap variants associated with human traits.
url https://doi.org/10.1038/s41467-018-03274-0
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