Thermal Stability as a Determinant of AAV Serotype Identity

Thermal Stability as a Determinant of AAV Serotype Identity

Currently, there are over 150 ongoing clinical trials utilizing adeno-associated viruses (AAVs) to target various genetic diseases, including hemophilia (AAV2 and AAV8), congenital heart failure (AAV1 and AAV6), cystic fibrosis (AAV2), rheumatoid arthritis (AAV2), and Batten disease (AAVrh.10). Prio...

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Bibliographic Details
Main Authors:	Antonette Bennett, Saajan Patel, Mario Mietzsch, Ariana Jose, Bridget Lins-Austin, Jennifer C. Yu, Brian Bothner, Robert McKenna, Mavis Agbandje-McKenna
Format:	Article
Language:	English
Published:	Elsevier 2017-09-01
Series:	Molecular Therapy: Methods & Clinical Development
Subjects:	adeno-associated virus AAV AAV capsid stability AAV serotype identification AAV vector buffers AAV buffer formulations differential scanning fluorimetry parvovirus stability viral vectors
Online Access:	http://www.sciencedirect.com/science/article/pii/S2329050117300864

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