Unravelling the immune signature of Plasmodium falciparum transmission-reducing immunity
Naturally acquired antibodies may inhibit Plasmodium survival in mosquitoes, alter malaria transmission dynamics, and form the basis for transmission-blocking vaccines. Here, using sera from malaria-exposed individuals, Stone et al. reveal novel antibody correlates of transmission-reducing activity.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2018-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-02646-2 |
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doaj-a727fd054ca84e01a19890f2a0ecb7bd2021-05-11T09:33:02ZengNature Publishing GroupNature Communications2041-17232018-02-019111410.1038/s41467-017-02646-2Unravelling the immune signature of Plasmodium falciparum transmission-reducing immunityWill J. R. Stone0Joseph J. Campo1André Lin Ouédraogo2Lisette Meerstein-Kessel3Isabelle Morlais4Dari Da5Anna Cohuet6Sandrine Nsango7Colin J. Sutherland8Marga van de Vegte-Bolmer9Rianne Siebelink-Stoter10Geert-Jan van Gemert11Wouter Graumans12Kjerstin Lanke13Adam D. Shandling14Jozelyn V. Pablo15Andy A. Teng16Sophie Jones17Roos M. de Jong18Amanda Fabra-García19John Bradley20Will Roeffen21Edwin Lasonder22Giuliana Gremo23Evelin Schwarzer24Chris J. Janse25Susheel K. Singh26Michael Theisen27Phil Felgner28Matthias Marti29Chris Drakeley30Robert Sauerwein31Teun Bousema32Matthijs M. Jore33Radboud Institute for Health Sciences, Radboud University Medical CenterAntigen Discovery Inc.Institute for Disease ModelingRadboud Institute for Health Sciences, Radboud University Medical CenterOrganisation de Coordination pour la lutte contre les Endémies en Afrique CentraleInstitut de Recherche en Sciences de la SantéInstitut de Recherche pour le Développement, MIVEGEC (IRD, CNRS, Univ. Montpellier)Organisation de Coordination pour la lutte contre les Endémies en Afrique CentraleDepartment of Immunology and Infection, London School of Hygiene and Tropical MedicineRadboud Institute for Molecular Life Sciences, Radboud University Medical CenterRadboud Institute for Molecular Life Sciences, Radboud University Medical CenterRadboud Institute for Molecular Life Sciences, Radboud University Medical CenterRadboud Institute for Molecular Life Sciences, Radboud University Medical CenterRadboud Institute for Molecular Life Sciences, Radboud University Medical CenterAntigen Discovery Inc.Antigen Discovery Inc.Antigen Discovery Inc.Department of Immunology and Infection, London School of Hygiene and Tropical MedicineRadboud Institute for Molecular Life Sciences, Radboud University Medical CenterRadboud Institute for Molecular Life Sciences, Radboud University Medical CenterMedical Research Council Tropical Epidemiology Group, London School of Hygiene and Tropical MedicineRadboud Institute for Molecular Life Sciences, Radboud University Medical CenterSchool of Biomedical and Healthcare Sciences, Plymouth University, Drakes CircusDepartment of Oncology, University of TorinoDepartment of Oncology, University of TorinoDepartment of Parasitology, Leiden University Medical Center (LUMC)Department for Congenital Diseases, Statens Serum InstitutDepartment for Congenital Diseases, Statens Serum InstitutDepartment of Medicine, University of California IrvineDepartment of Immunology and Infectious Diseases, Harvard School of Public HealthDepartment of Immunology and Infection, London School of Hygiene and Tropical MedicineRadboud Institute for Health Sciences, Radboud University Medical CenterRadboud Institute for Health Sciences, Radboud University Medical CenterRadboud Institute for Molecular Life Sciences, Radboud University Medical CenterNaturally acquired antibodies may inhibit Plasmodium survival in mosquitoes, alter malaria transmission dynamics, and form the basis for transmission-blocking vaccines. Here, using sera from malaria-exposed individuals, Stone et al. reveal novel antibody correlates of transmission-reducing activity.https://doi.org/10.1038/s41467-017-02646-2 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Will J. R. Stone Joseph J. Campo André Lin Ouédraogo Lisette Meerstein-Kessel Isabelle Morlais Dari Da Anna Cohuet Sandrine Nsango Colin J. Sutherland Marga van de Vegte-Bolmer Rianne Siebelink-Stoter Geert-Jan van Gemert Wouter Graumans Kjerstin Lanke Adam D. Shandling Jozelyn V. Pablo Andy A. Teng Sophie Jones Roos M. de Jong Amanda Fabra-García John Bradley Will Roeffen Edwin Lasonder Giuliana Gremo Evelin Schwarzer Chris J. Janse Susheel K. Singh Michael Theisen Phil Felgner Matthias Marti Chris Drakeley Robert Sauerwein Teun Bousema Matthijs M. Jore |
| spellingShingle |
Will J. R. Stone Joseph J. Campo André Lin Ouédraogo Lisette Meerstein-Kessel Isabelle Morlais Dari Da Anna Cohuet Sandrine Nsango Colin J. Sutherland Marga van de Vegte-Bolmer Rianne Siebelink-Stoter Geert-Jan van Gemert Wouter Graumans Kjerstin Lanke Adam D. Shandling Jozelyn V. Pablo Andy A. Teng Sophie Jones Roos M. de Jong Amanda Fabra-García John Bradley Will Roeffen Edwin Lasonder Giuliana Gremo Evelin Schwarzer Chris J. Janse Susheel K. Singh Michael Theisen Phil Felgner Matthias Marti Chris Drakeley Robert Sauerwein Teun Bousema Matthijs M. Jore Unravelling the immune signature of Plasmodium falciparum transmission-reducing immunity Nature Communications |
| author_facet |
Will J. R. Stone Joseph J. Campo André Lin Ouédraogo Lisette Meerstein-Kessel Isabelle Morlais Dari Da Anna Cohuet Sandrine Nsango Colin J. Sutherland Marga van de Vegte-Bolmer Rianne Siebelink-Stoter Geert-Jan van Gemert Wouter Graumans Kjerstin Lanke Adam D. Shandling Jozelyn V. Pablo Andy A. Teng Sophie Jones Roos M. de Jong Amanda Fabra-García John Bradley Will Roeffen Edwin Lasonder Giuliana Gremo Evelin Schwarzer Chris J. Janse Susheel K. Singh Michael Theisen Phil Felgner Matthias Marti Chris Drakeley Robert Sauerwein Teun Bousema Matthijs M. Jore |
| author_sort |
Will J. R. Stone |
| title |
Unravelling the immune signature of Plasmodium falciparum transmission-reducing immunity |
| title_short |
Unravelling the immune signature of Plasmodium falciparum transmission-reducing immunity |
| title_full |
Unravelling the immune signature of Plasmodium falciparum transmission-reducing immunity |
| title_fullStr |
Unravelling the immune signature of Plasmodium falciparum transmission-reducing immunity |
| title_full_unstemmed |
Unravelling the immune signature of Plasmodium falciparum transmission-reducing immunity |
| title_sort |
unravelling the immune signature of plasmodium falciparum transmission-reducing immunity |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2018-02-01 |
| description |
Naturally acquired antibodies may inhibit Plasmodium survival in mosquitoes, alter malaria transmission dynamics, and form the basis for transmission-blocking vaccines. Here, using sera from malaria-exposed individuals, Stone et al. reveal novel antibody correlates of transmission-reducing activity. |
| url |
https://doi.org/10.1038/s41467-017-02646-2 |
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1721449679817801728 |