Frequent high-risk HPV co-infections excluding types 16 or 18 in cervical neoplasia in Guadeloupe
Abstract Background Cervical cancer is the fourth cancer worldwide. The Human Papilloma Virus is responsible for 99% of the cases but the distribution of its genotypes varies among populations. We aimed to identify HPV genotypes distribution in women with grade 2/3 cervical intraepithelial dysplasia...
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doaj-a728422d6d544708b1b032aaf4efb2f82021-03-21T12:50:54ZengBMCBMC Cancer1471-24072021-03-012111910.1186/s12885-021-07940-3Frequent high-risk HPV co-infections excluding types 16 or 18 in cervical neoplasia in GuadeloupeStanie Gaete0Aviane Auguste1Bernard Bhakkan2Jessica Peruvien3Cecile Herrmann-Storck4Youri Socrier5Abdoulaye Diedhiou6Jacqueline Deloumeaux7Biological Resources Center Karubiotec™, BRIF n° KARUBIOTEC-GUA-00971Guadeloupe cancer registry, University Hospital of GuadeloupeGuadeloupe cancer registry, University Hospital of GuadeloupeGuadeloupe cancer registry, University Hospital of GuadeloupeVirology-Microbiology Unit, University Hospital of GuadeloupePathology Laboratory ALIZESPathology Laboratory, University Hospital of GuadeloupeBiological Resources Center Karubiotec™, BRIF n° KARUBIOTEC-GUA-00971Abstract Background Cervical cancer is the fourth cancer worldwide. The Human Papilloma Virus is responsible for 99% of the cases but the distribution of its genotypes varies among populations. We aimed to identify HPV genotypes distribution in women with grade 2/3 cervical intraepithelial dysplasia or invasive cervical cancer in Guadeloupe, a French Caribbean territory with a population mainly of African descent. Methods We used paraffin-embedded tumors for viral DNA extraction from women diagnosed between 2014 and 2016 and identified by the population-based cancer registry. The HPV Genotyping was performed with the InnoLIPA HPV Genotyping Extra kit®. Results Overall, 213 samples out of the 321 eligible records were analyzed. The HPV status was positive for 94% of the cases. The five most common oncogenic HPV genotypes were HPV31 (47%), HPV33 (38%), HPV16 (32%), HPV44 (31%) and HPV26 (28%). HPV18 was found in only in 5% of the cases. Among the studied cases, 94% had multiple infections. More than 60% of single infections were HPV16-related, accounting for 35% of HPV16 infections. Conclusions These results show a different distribution of oncogenic HPVs in Guadeloupe with “31 > 33 > 16” and a high frequency of multiple infections. Despite a lower coverage, the nine-valent vaccine is nevertheless adequate.https://doi.org/10.1186/s12885-021-07940-3Human papilloma virusCervical cancerCaribbeanGuadeloupe |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Stanie Gaete Aviane Auguste Bernard Bhakkan Jessica Peruvien Cecile Herrmann-Storck Youri Socrier Abdoulaye Diedhiou Jacqueline Deloumeaux |
spellingShingle |
Stanie Gaete Aviane Auguste Bernard Bhakkan Jessica Peruvien Cecile Herrmann-Storck Youri Socrier Abdoulaye Diedhiou Jacqueline Deloumeaux Frequent high-risk HPV co-infections excluding types 16 or 18 in cervical neoplasia in Guadeloupe BMC Cancer Human papilloma virus Cervical cancer Caribbean Guadeloupe |
author_facet |
Stanie Gaete Aviane Auguste Bernard Bhakkan Jessica Peruvien Cecile Herrmann-Storck Youri Socrier Abdoulaye Diedhiou Jacqueline Deloumeaux |
author_sort |
Stanie Gaete |
title |
Frequent high-risk HPV co-infections excluding types 16 or 18 in cervical neoplasia in Guadeloupe |
title_short |
Frequent high-risk HPV co-infections excluding types 16 or 18 in cervical neoplasia in Guadeloupe |
title_full |
Frequent high-risk HPV co-infections excluding types 16 or 18 in cervical neoplasia in Guadeloupe |
title_fullStr |
Frequent high-risk HPV co-infections excluding types 16 or 18 in cervical neoplasia in Guadeloupe |
title_full_unstemmed |
Frequent high-risk HPV co-infections excluding types 16 or 18 in cervical neoplasia in Guadeloupe |
title_sort |
frequent high-risk hpv co-infections excluding types 16 or 18 in cervical neoplasia in guadeloupe |
publisher |
BMC |
series |
BMC Cancer |
issn |
1471-2407 |
publishDate |
2021-03-01 |
description |
Abstract Background Cervical cancer is the fourth cancer worldwide. The Human Papilloma Virus is responsible for 99% of the cases but the distribution of its genotypes varies among populations. We aimed to identify HPV genotypes distribution in women with grade 2/3 cervical intraepithelial dysplasia or invasive cervical cancer in Guadeloupe, a French Caribbean territory with a population mainly of African descent. Methods We used paraffin-embedded tumors for viral DNA extraction from women diagnosed between 2014 and 2016 and identified by the population-based cancer registry. The HPV Genotyping was performed with the InnoLIPA HPV Genotyping Extra kit®. Results Overall, 213 samples out of the 321 eligible records were analyzed. The HPV status was positive for 94% of the cases. The five most common oncogenic HPV genotypes were HPV31 (47%), HPV33 (38%), HPV16 (32%), HPV44 (31%) and HPV26 (28%). HPV18 was found in only in 5% of the cases. Among the studied cases, 94% had multiple infections. More than 60% of single infections were HPV16-related, accounting for 35% of HPV16 infections. Conclusions These results show a different distribution of oncogenic HPVs in Guadeloupe with “31 > 33 > 16” and a high frequency of multiple infections. Despite a lower coverage, the nine-valent vaccine is nevertheless adequate. |
topic |
Human papilloma virus Cervical cancer Caribbean Guadeloupe |
url |
https://doi.org/10.1186/s12885-021-07940-3 |
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