Reinforcing one-carbon metabolism via folic acid/Folr1 promotes β-cell differentiation

Regeneration of insulin-producing beta-cells may become a future alternative treatment of diabetes. Here the authors report a genetic screen in a zebrafish model that mimics the loss of beta-cells in diabetes, and identified that the folate receptor Folr1 or folinic acid treatment can stimulate beta...

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Main Authors:	Christos Karampelias, Habib Rezanejad, Mandy Rosko, Likun Duan, Jing Lu, Laura Pazzagli, Philippe Bertolino, Carolyn E. Cesta, Xiaojing Liu, Gregory S. Korbutt, Olov Andersson
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-06-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-021-23673-0

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spelling	doaj-a728a4a3f5614b2a9d19997422e580552021-06-13T11:16:09ZengNature Publishing GroupNature Communications2041-17232021-06-0112111310.1038/s41467-021-23673-0Reinforcing one-carbon metabolism via folic acid/Folr1 promotes β-cell differentiationChristos Karampelias0Habib Rezanejad1Mandy Rosko2Likun Duan3Jing Lu4Laura Pazzagli5Philippe Bertolino6Carolyn E. Cesta7Xiaojing Liu8Gregory S. Korbutt9Olov Andersson10Department of Cell and Molecular Biology, Karolinska InstitutetDepartment of Surgery and Alberta Diabetes Institute, University of AlbertaDepartment of Surgery and Alberta Diabetes Institute, University of AlbertaDepartment of Molecular and Structural Biochemistry, NC State UniversityDepartment of Cell and Molecular Biology, Karolinska InstitutetCentre for Pharmacoepidemiology, Department of Medicine Solna, Karolinska InstitutetCancer Research Centre of Lyon, INSERM U1052, CNRS UMR5286, Claude Bernard UniversityCentre for Pharmacoepidemiology, Department of Medicine Solna, Karolinska InstitutetDepartment of Molecular and Structural Biochemistry, NC State UniversityDepartment of Surgery and Alberta Diabetes Institute, University of AlbertaDepartment of Cell and Molecular Biology, Karolinska InstitutetRegeneration of insulin-producing beta-cells may become a future alternative treatment of diabetes. Here the authors report a genetic screen in a zebrafish model that mimics the loss of beta-cells in diabetes, and identified that the folate receptor Folr1 or folinic acid treatment can stimulate beta-cell regeneration.https://doi.org/10.1038/s41467-021-23673-0
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Christos Karampelias Habib Rezanejad Mandy Rosko Likun Duan Jing Lu Laura Pazzagli Philippe Bertolino Carolyn E. Cesta Xiaojing Liu Gregory S. Korbutt Olov Andersson
spellingShingle	Christos Karampelias Habib Rezanejad Mandy Rosko Likun Duan Jing Lu Laura Pazzagli Philippe Bertolino Carolyn E. Cesta Xiaojing Liu Gregory S. Korbutt Olov Andersson Reinforcing one-carbon metabolism via folic acid/Folr1 promotes β-cell differentiation Nature Communications
author_facet	Christos Karampelias Habib Rezanejad Mandy Rosko Likun Duan Jing Lu Laura Pazzagli Philippe Bertolino Carolyn E. Cesta Xiaojing Liu Gregory S. Korbutt Olov Andersson
author_sort	Christos Karampelias
title	Reinforcing one-carbon metabolism via folic acid/Folr1 promotes β-cell differentiation
title_short	Reinforcing one-carbon metabolism via folic acid/Folr1 promotes β-cell differentiation
title_full	Reinforcing one-carbon metabolism via folic acid/Folr1 promotes β-cell differentiation
title_fullStr	Reinforcing one-carbon metabolism via folic acid/Folr1 promotes β-cell differentiation
title_full_unstemmed	Reinforcing one-carbon metabolism via folic acid/Folr1 promotes β-cell differentiation
title_sort	reinforcing one-carbon metabolism via folic acid/folr1 promotes β-cell differentiation
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-06-01
description	Regeneration of insulin-producing beta-cells may become a future alternative treatment of diabetes. Here the authors report a genetic screen in a zebrafish model that mimics the loss of beta-cells in diabetes, and identified that the folate receptor Folr1 or folinic acid treatment can stimulate beta-cell regeneration.
url	https://doi.org/10.1038/s41467-021-23673-0
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Reinforcing one-carbon metabolism via folic acid/Folr1 promotes β-cell differentiation

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