Efficacy of Androgen Deprivation Therapy in Patients with Metastatic Castration-Resistant Prostate Cancer Receiving Docetaxel-Based Chemotherapy
Purpose: The purpose of this study was to determine the comparative effectiveness of androgen deprivation therapy (ADT) combined with docetaxel (DTX)-based chemotherapy in Korean and Japanese castration-resistant prostate cancer (CRPC) patient cohorts. Materials and Methods: Metastatic CRPC patie...
Main Authors: | , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Korean Society for Sexual Medicine and Andrology
2020-04-01
|
Series: | The World Journal of Men's Health |
Subjects: |
id |
doaj-a72fb5b672c24e80b85e97a061cca142 |
---|---|
record_format |
Article |
spelling |
doaj-a72fb5b672c24e80b85e97a061cca1422020-11-25T03:51:40ZengKorean Society for Sexual Medicine and AndrologyThe World Journal of Men's Health2287-42082287-46902020-04-0138222623510.5534/wjmh.190029Efficacy of Androgen Deprivation Therapy in Patients with Metastatic Castration-Resistant Prostate Cancer Receiving Docetaxel-Based ChemotherapyKyungchan Min0https://orcid.org/0000-0001-5238-6265Jae-Wook Chung1https://orcid.org/0000-0002-1055-2357Yun-Sok Ha2https://orcid.org/0000-0003-3732-9814Jun Nyung Lee3https://orcid.org/0000-0002-6342-9846Bum Soo Kim4https://orcid.org/0000-0002-4873-3049Hyun Tae Kim5https://orcid.org/0000-0002-4730-3776Tae-Hwan Kim6https://orcid.org/0000-0003-4924-4826Eun Sang Yoo7https://orcid.org/0000-0002-7442-6886Tae Gyun Kwon8https://orcid.org/0000-0002-4390-0952Sung Kwang Chung9https://orcid.org/0000-0003-4709-2718Masatoshi Tanaka10https://orcid.org/0000-0001-5582-8647Shin Egawa11https://orcid.org/0000-0002-9198-5559Takahiro Kimura12https://orcid.org/0000-0002-5673-1553Seock Hwan Choi13https://orcid.org/0000-0003-3796-2601Kyungpook National University Chilgok HospitalKyungpook National University Chilgok HospitalKyungpook National University HospitalKyungpook National University Chilgok HospitalKyungpook National University HospitalKyungpook National University Chilgok HospitalKyungpook National University Chilgok HospitalKyungpook National University HospitalKyungpook National University Chilgok HospitalKyungpook National University HospitalJikei University School of MedicineJikei University School of MedicineJikei University School of MedicineKyungpook National University HospitalPurpose: The purpose of this study was to determine the comparative effectiveness of androgen deprivation therapy (ADT) combined with docetaxel (DTX)-based chemotherapy in Korean and Japanese castration-resistant prostate cancer (CRPC) patient cohorts. Materials and Methods: Metastatic CRPC patients who underwent more than three DTX-based chemotherapy cycles in Korea and Japan between 2002 and 2017 were retrospectively analyzed and divided into the DTX-only (DTX, n=30) and combination (DTX+ADT, n=46) groups. Progression-free survival (PFS) was calculated as the time from the start of chemotherapy to the occurrence of either disease progression (prostate-specific antigen [PSA] progression or radiographic progression) or death. The primary end point was PFS and the secondary end point was overall survival (OS). Results: In the DTX and DTX+ADT groups, the median PFS was 6.0 and 11.0 months (log-rank p=0.053). The multivariate Cox regression analysis revealed that the significant predicting factors of PFS were ADT administration (hazard ratio [HR], 0.478; 95% confidence interval [CI], 0.284–0.804; p=0.005) and number of DTX-based chemotherapy cycles (HR, 0.934; 95% CI, 0.899–0.970; p<0.001). In the DTX and DTX+ADT groups, the median OS was 16.0 and 19.5 months (log-rank p=0.825). Through multiple Cox regression analysis, we found that the significant predicting factors of OS were the PSA nadir level (HR, 1.001; 95% CI, 1.000–1.002; p<0.001) and number of DTX-based chemotherapy cycles (HR, 0.932; 95% CI, 0.876–0.991; p=0.024). Conclusions: Concurrent DTX-based chemotherapy and ADT may be beneficial compared with DTX-based chemotherapy alone in chemotherapy-naïve metastatic CRPC patients in terms of the PFS, but not the OS.antineoplastic hormonal drugsdocetaxelprogression-free survivalprostate cancer |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kyungchan Min Jae-Wook Chung Yun-Sok Ha Jun Nyung Lee Bum Soo Kim Hyun Tae Kim Tae-Hwan Kim Eun Sang Yoo Tae Gyun Kwon Sung Kwang Chung Masatoshi Tanaka Shin Egawa Takahiro Kimura Seock Hwan Choi |
spellingShingle |
Kyungchan Min Jae-Wook Chung Yun-Sok Ha Jun Nyung Lee Bum Soo Kim Hyun Tae Kim Tae-Hwan Kim Eun Sang Yoo Tae Gyun Kwon Sung Kwang Chung Masatoshi Tanaka Shin Egawa Takahiro Kimura Seock Hwan Choi Efficacy of Androgen Deprivation Therapy in Patients with Metastatic Castration-Resistant Prostate Cancer Receiving Docetaxel-Based Chemotherapy The World Journal of Men's Health antineoplastic hormonal drugs docetaxel progression-free survival prostate cancer |
author_facet |
Kyungchan Min Jae-Wook Chung Yun-Sok Ha Jun Nyung Lee Bum Soo Kim Hyun Tae Kim Tae-Hwan Kim Eun Sang Yoo Tae Gyun Kwon Sung Kwang Chung Masatoshi Tanaka Shin Egawa Takahiro Kimura Seock Hwan Choi |
author_sort |
Kyungchan Min |
title |
Efficacy of Androgen Deprivation Therapy in Patients with Metastatic Castration-Resistant Prostate Cancer Receiving Docetaxel-Based Chemotherapy |
title_short |
Efficacy of Androgen Deprivation Therapy in Patients with Metastatic Castration-Resistant Prostate Cancer Receiving Docetaxel-Based Chemotherapy |
title_full |
Efficacy of Androgen Deprivation Therapy in Patients with Metastatic Castration-Resistant Prostate Cancer Receiving Docetaxel-Based Chemotherapy |
title_fullStr |
Efficacy of Androgen Deprivation Therapy in Patients with Metastatic Castration-Resistant Prostate Cancer Receiving Docetaxel-Based Chemotherapy |
title_full_unstemmed |
Efficacy of Androgen Deprivation Therapy in Patients with Metastatic Castration-Resistant Prostate Cancer Receiving Docetaxel-Based Chemotherapy |
title_sort |
efficacy of androgen deprivation therapy in patients with metastatic castration-resistant prostate cancer receiving docetaxel-based chemotherapy |
publisher |
Korean Society for Sexual Medicine and Andrology |
series |
The World Journal of Men's Health |
issn |
2287-4208 2287-4690 |
publishDate |
2020-04-01 |
description |
Purpose: The purpose of this study was to determine the comparative effectiveness of androgen deprivation therapy (ADT)
combined with docetaxel (DTX)-based chemotherapy in Korean and Japanese castration-resistant prostate cancer (CRPC) patient
cohorts.
Materials and Methods: Metastatic CRPC patients who underwent more than three DTX-based chemotherapy cycles in Korea
and Japan between 2002 and 2017 were retrospectively analyzed and divided into the DTX-only (DTX, n=30) and combination
(DTX+ADT, n=46) groups. Progression-free survival (PFS) was calculated as the time from the start of chemotherapy
to the occurrence of either disease progression (prostate-specific antigen [PSA] progression or radiographic progression) or
death. The primary end point was PFS and the secondary end point was overall survival (OS).
Results: In the DTX and DTX+ADT groups, the median PFS was 6.0 and 11.0 months (log-rank p=0.053). The multivariate
Cox regression analysis revealed that the significant predicting factors of PFS were ADT administration (hazard ratio [HR],
0.478; 95% confidence interval [CI], 0.284–0.804; p=0.005) and number of DTX-based chemotherapy cycles (HR, 0.934;
95% CI, 0.899–0.970; p<0.001). In the DTX and DTX+ADT groups, the median OS was 16.0 and 19.5 months (log-rank
p=0.825). Through multiple Cox regression analysis, we found that the significant predicting factors of OS were the PSA nadir
level (HR, 1.001; 95% CI, 1.000–1.002; p<0.001) and number of DTX-based chemotherapy cycles (HR, 0.932; 95% CI,
0.876–0.991; p=0.024).
Conclusions: Concurrent DTX-based chemotherapy and ADT may be beneficial compared with DTX-based chemotherapy
alone in chemotherapy-naïve metastatic CRPC patients in terms of the PFS, but not the OS. |
topic |
antineoplastic hormonal drugs docetaxel progression-free survival prostate cancer |
work_keys_str_mv |
AT kyungchanmin efficacyofandrogendeprivationtherapyinpatientswithmetastaticcastrationresistantprostatecancerreceivingdocetaxelbasedchemotherapy AT jaewookchung efficacyofandrogendeprivationtherapyinpatientswithmetastaticcastrationresistantprostatecancerreceivingdocetaxelbasedchemotherapy AT yunsokha efficacyofandrogendeprivationtherapyinpatientswithmetastaticcastrationresistantprostatecancerreceivingdocetaxelbasedchemotherapy AT junnyunglee efficacyofandrogendeprivationtherapyinpatientswithmetastaticcastrationresistantprostatecancerreceivingdocetaxelbasedchemotherapy AT bumsookim efficacyofandrogendeprivationtherapyinpatientswithmetastaticcastrationresistantprostatecancerreceivingdocetaxelbasedchemotherapy AT hyuntaekim efficacyofandrogendeprivationtherapyinpatientswithmetastaticcastrationresistantprostatecancerreceivingdocetaxelbasedchemotherapy AT taehwankim efficacyofandrogendeprivationtherapyinpatientswithmetastaticcastrationresistantprostatecancerreceivingdocetaxelbasedchemotherapy AT eunsangyoo efficacyofandrogendeprivationtherapyinpatientswithmetastaticcastrationresistantprostatecancerreceivingdocetaxelbasedchemotherapy AT taegyunkwon efficacyofandrogendeprivationtherapyinpatientswithmetastaticcastrationresistantprostatecancerreceivingdocetaxelbasedchemotherapy AT sungkwangchung efficacyofandrogendeprivationtherapyinpatientswithmetastaticcastrationresistantprostatecancerreceivingdocetaxelbasedchemotherapy AT masatoshitanaka efficacyofandrogendeprivationtherapyinpatientswithmetastaticcastrationresistantprostatecancerreceivingdocetaxelbasedchemotherapy AT shinegawa efficacyofandrogendeprivationtherapyinpatientswithmetastaticcastrationresistantprostatecancerreceivingdocetaxelbasedchemotherapy AT takahirokimura efficacyofandrogendeprivationtherapyinpatientswithmetastaticcastrationresistantprostatecancerreceivingdocetaxelbasedchemotherapy AT seockhwanchoi efficacyofandrogendeprivationtherapyinpatientswithmetastaticcastrationresistantprostatecancerreceivingdocetaxelbasedchemotherapy |
_version_ |
1724486195649445888 |