Bradykinin receptor deficiency or antagonism do not impact the host response during gram-negative pneumonia-derived sepsis

Bradykinin receptor deficiency or antagonism do not impact the host response during gram-negative pneumonia-derived sepsis

Abstract Background Kinins are short peptides with a wide range of proinflammatory properties that are generated from kininogens in the so-called kallikrein-kinin system. Kinins exert their biological activities through stimulation of two distinct receptor subtypes, the kinin or bradykinin B1 and B2...

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Bibliographic Details
Main Authors: Chao Ding, Jack Yang, Cornelis van’t Veer, Tom van der Poll
Format: Article
Language:English
Published: SpringerOpen 2019-03-01
Series:Intensive Care Medicine Experimental
Subjects:
Bradykinin
Pneumonia
Sepsis
Inflammation
Online Access:http://link.springer.com/article/10.1186/s40635-019-0228-3

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