CLINICAL PARTICULARITIES AND DIAGNOSTIC METHODS IN THE HYDATIDIFORM MOLE

• Main Authors: Eduard Crauciuc, Eugen Ungureanu, Ovidiu Toma, Dragos Crauciuc, Mariana Bratu
• Format: Article
• Language: English
• Published: "Alexandru Ioan Cuza" University of Iași 2013-12-01
• Series: Analele Ştiinţifice Ale Universităţii Alexandru Ioan Cuza din Iași,Sectiunea II A : Genetica si Biologie Moleculara
• Online Access: http://www.gbm.bio.uaic.ro/index.php/gbm/article/view/1094

Aim of this study was to establish a significant way to the prognosis improvement in trophoblastic pathology in patients with hydatidiform mole. Objective. A mole is a particularity of embryonic development where a pregnancy occurs paradoxically without an embryo (the mole pregnancy) and develops only its placental tissue. It is important to demonstrate that the clinical diagnostic should always be completed by a histo-pathological diagnostic and also by the description of the natural history of the disease until the time of diagnostic. Material and method. The cases included in the study (n=45) were hospitalized in ”Elena Doamna” Clinical Hospital Iaşi, in the period of time between 2008 and 2013, and diagnosed with hydatidiform mole. The study was a retrospective one, case-control type. Starting from the already diagnosed illness and following the clinical and paraclinical parameters outlined in literature, the objective of the study was to establish the main risk factors that trigger the molar pregnancy. Results. The epidemiological characteristics show the following main risk factors for a molar pregnancy: age over 30, urban area, tobacco and alcohol consumption. The mean values of βHCG decreased significantly after the hydatidiform mole was removed, from 26,624 to 9,859 mUI/ml (p<0.05).Conclusions. Every woman with a history of hydatidiform mole has an increased risk of developing carcinoma. After the complete or partial removal of the hydatidiform mole, it is necessary to monitor the values of βHCG twice a month until they stabilize.