Current Approach in Radiochemical Quality Control of the 99mTc-Radiopharmaceuticals: a mini-review

• Main Authors: Ana Cláudia Camargo Miranda, Ana Claudia Ranucci Durante, Leonardo Lima Fuscaldi, Marycel Figols de Barboza
• Format: Article
• Language: English
• Published: Instituto de Tecnologia do Paraná (Tecpar)
• Series: Brazilian Archives of Biology and Technology
• Subjects: 99mTc-radiopharmaceuticals; Radiochemical purity; Ascendant chromatography; Chromatographic system; Dose calibrator
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132019000100903&lng=en&tlng=en

Abstract To present optimized chromatographic systems for radiochemical purity (RCP) evaluation of 99mTc-eluate and 99mTc-radiopharmaceuticals, as well as to assess doses calibrator reliability for routine purposes in hospital radiopharmacies. RCP was determined by different systems and radioactivity was quantified by TLC-scanner, doses calibrator and gamma-counter. Suitable and optimized systems were presented for RCP analyses. No significant differences were observed between radioactivity counting devices and, thus, doses calibrator showed reliability for RCP determination in hospital radiopharmacies.