Current Approach in Radiochemical Quality Control of the 99mTc-Radiopharmaceuticals: a mini-review
Abstract To present optimized chromatographic systems for radiochemical purity (RCP) evaluation of 99mTc-eluate and 99mTc-radiopharmaceuticals, as well as to assess doses calibrator reliability for routine purposes in hospital radiopharmacies. RCP was determined by different systems and radioactivit...
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doaj-a745c4767e454f21abc1b4866dd8912c2020-11-24T22:16:03ZengInstituto de Tecnologia do Paraná (Tecpar)Brazilian Archives of Biology and Technology1678-43246210.1590/1678-4324-2019180545S1516-89132019000100903Current Approach in Radiochemical Quality Control of the 99mTc-Radiopharmaceuticals: a mini-reviewAna Cláudia Camargo MirandaAna Claudia Ranucci DuranteLeonardo Lima FuscaldiMarycel Figols de BarbozaAbstract To present optimized chromatographic systems for radiochemical purity (RCP) evaluation of 99mTc-eluate and 99mTc-radiopharmaceuticals, as well as to assess doses calibrator reliability for routine purposes in hospital radiopharmacies. RCP was determined by different systems and radioactivity was quantified by TLC-scanner, doses calibrator and gamma-counter. Suitable and optimized systems were presented for RCP analyses. No significant differences were observed between radioactivity counting devices and, thus, doses calibrator showed reliability for RCP determination in hospital radiopharmacies.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132019000100903&lng=en&tlng=en99mTc-radiopharmaceuticalsRadiochemical purityAscendant chromatographyChromatographic systemDose calibrator |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ana Cláudia Camargo Miranda Ana Claudia Ranucci Durante Leonardo Lima Fuscaldi Marycel Figols de Barboza |
spellingShingle |
Ana Cláudia Camargo Miranda Ana Claudia Ranucci Durante Leonardo Lima Fuscaldi Marycel Figols de Barboza Current Approach in Radiochemical Quality Control of the 99mTc-Radiopharmaceuticals: a mini-review Brazilian Archives of Biology and Technology 99mTc-radiopharmaceuticals Radiochemical purity Ascendant chromatography Chromatographic system Dose calibrator |
author_facet |
Ana Cláudia Camargo Miranda Ana Claudia Ranucci Durante Leonardo Lima Fuscaldi Marycel Figols de Barboza |
author_sort |
Ana Cláudia Camargo Miranda |
title |
Current Approach in Radiochemical Quality Control of the 99mTc-Radiopharmaceuticals: a mini-review |
title_short |
Current Approach in Radiochemical Quality Control of the 99mTc-Radiopharmaceuticals: a mini-review |
title_full |
Current Approach in Radiochemical Quality Control of the 99mTc-Radiopharmaceuticals: a mini-review |
title_fullStr |
Current Approach in Radiochemical Quality Control of the 99mTc-Radiopharmaceuticals: a mini-review |
title_full_unstemmed |
Current Approach in Radiochemical Quality Control of the 99mTc-Radiopharmaceuticals: a mini-review |
title_sort |
current approach in radiochemical quality control of the 99mtc-radiopharmaceuticals: a mini-review |
publisher |
Instituto de Tecnologia do Paraná (Tecpar) |
series |
Brazilian Archives of Biology and Technology |
issn |
1678-4324 |
description |
Abstract To present optimized chromatographic systems for radiochemical purity (RCP) evaluation of 99mTc-eluate and 99mTc-radiopharmaceuticals, as well as to assess doses calibrator reliability for routine purposes in hospital radiopharmacies. RCP was determined by different systems and radioactivity was quantified by TLC-scanner, doses calibrator and gamma-counter. Suitable and optimized systems were presented for RCP analyses. No significant differences were observed between radioactivity counting devices and, thus, doses calibrator showed reliability for RCP determination in hospital radiopharmacies. |
topic |
99mTc-radiopharmaceuticals Radiochemical purity Ascendant chromatography Chromatographic system Dose calibrator |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132019000100903&lng=en&tlng=en |
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