The ASIC3/P2X3 cognate receptor is a pain-relevant and ligand-gated cationic channel
Two subclasses of ligand-gated ion channels (ASIC3 and P2X3) are both present at sensory neurons and might be therefore subject to receptor crosstalk. Here authors use electrophysiology, biochemistry and co-immunoprecipitation to show that the two ion channels interact and affect P2X3 currents.
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Nature Publishing Group
2018-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-03728-5 |
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doaj-a74b5c103f5b4b358a8a947c36ebe64a2021-05-11T09:25:05ZengNature Publishing GroupNature Communications2041-17232018-04-019111810.1038/s41467-018-03728-5The ASIC3/P2X3 cognate receptor is a pain-relevant and ligand-gated cationic channelGabriele Stephan0Lumei Huang1Yong Tang2Sandra Vilotti3Elsa Fabbretti4Ye Yu5Wolfgang Nörenberg6Heike Franke7Flóra Gölöncsér8Beáta Sperlágh9Anke Dopychai10Ralf Hausmann11Günther Schmalzing12Patrizia Rubini13Peter Illes14Rudolf-Boehm-Institut für Pharmakologie und Toxikologie, University of LeipzigRudolf-Boehm-Institut für Pharmakologie und Toxikologie, University of LeipzigAcupuncture and Tuina School, Chengdu University of Traditional Chinese MedicineNeurobiology Sector, International School for Advanced StudiesDepartment of Life Sciences, University of TriesteInstitute of Neuroscience and State Key Laboratory of NeuroscienceRudolf-Boehm-Institut für Pharmakologie und Toxikologie, University of LeipzigRudolf-Boehm-Institut für Pharmakologie und Toxikologie, University of LeipzigLaboratory of Molecular Pharmacology, Institute of Experimental Medicine, Hungarian Academy of SciencesLaboratory of Molecular Pharmacology, Institute of Experimental Medicine, Hungarian Academy of SciencesMolecular Pharmacology, Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen UniversityMolecular Pharmacology, Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen UniversityMolecular Pharmacology, Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen UniversityRudolf-Boehm-Institut für Pharmakologie und Toxikologie, University of LeipzigRudolf-Boehm-Institut für Pharmakologie und Toxikologie, University of LeipzigTwo subclasses of ligand-gated ion channels (ASIC3 and P2X3) are both present at sensory neurons and might be therefore subject to receptor crosstalk. Here authors use electrophysiology, biochemistry and co-immunoprecipitation to show that the two ion channels interact and affect P2X3 currents.https://doi.org/10.1038/s41467-018-03728-5 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Gabriele Stephan Lumei Huang Yong Tang Sandra Vilotti Elsa Fabbretti Ye Yu Wolfgang Nörenberg Heike Franke Flóra Gölöncsér Beáta Sperlágh Anke Dopychai Ralf Hausmann Günther Schmalzing Patrizia Rubini Peter Illes |
| spellingShingle |
Gabriele Stephan Lumei Huang Yong Tang Sandra Vilotti Elsa Fabbretti Ye Yu Wolfgang Nörenberg Heike Franke Flóra Gölöncsér Beáta Sperlágh Anke Dopychai Ralf Hausmann Günther Schmalzing Patrizia Rubini Peter Illes The ASIC3/P2X3 cognate receptor is a pain-relevant and ligand-gated cationic channel Nature Communications |
| author_facet |
Gabriele Stephan Lumei Huang Yong Tang Sandra Vilotti Elsa Fabbretti Ye Yu Wolfgang Nörenberg Heike Franke Flóra Gölöncsér Beáta Sperlágh Anke Dopychai Ralf Hausmann Günther Schmalzing Patrizia Rubini Peter Illes |
| author_sort |
Gabriele Stephan |
| title |
The ASIC3/P2X3 cognate receptor is a pain-relevant and ligand-gated cationic channel |
| title_short |
The ASIC3/P2X3 cognate receptor is a pain-relevant and ligand-gated cationic channel |
| title_full |
The ASIC3/P2X3 cognate receptor is a pain-relevant and ligand-gated cationic channel |
| title_fullStr |
The ASIC3/P2X3 cognate receptor is a pain-relevant and ligand-gated cationic channel |
| title_full_unstemmed |
The ASIC3/P2X3 cognate receptor is a pain-relevant and ligand-gated cationic channel |
| title_sort |
asic3/p2x3 cognate receptor is a pain-relevant and ligand-gated cationic channel |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2018-04-01 |
| description |
Two subclasses of ligand-gated ion channels (ASIC3 and P2X3) are both present at sensory neurons and might be therefore subject to receptor crosstalk. Here authors use electrophysiology, biochemistry and co-immunoprecipitation to show that the two ion channels interact and affect P2X3 currents. |
| url |
https://doi.org/10.1038/s41467-018-03728-5 |
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