Mouse Mammary Tumor Virus Promoter-Containing Retroviral Promoter Conversion Vectors for Gene-Directed Enzyme Prodrug Therapy are Functional in Vitro and in Vivo

Mouse Mammary Tumor Virus Promoter-Containing Retroviral Promoter Conversion Vectors for Gene-Directed Enzyme Prodrug Therapy are Functional in Vitro and in Vivo

Gene directed-enzyme prodrug therapy (GDEPT) is an approach for sensitization of tumor cells to an enzymatically activated, otherwise nontoxic, prodrug. Cytochrome P450 2B1 (CYP2B1) metabolizes the prodrugs cyclophosphamide (CPA) and ifosfamide (IFA) to produce the cytotoxic substances phosphoramide...

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Bibliographic Details
Main Authors:	Reinhard Klein, Bärbel Ruttkowski, Sonja Schwab, Thomas Peterbauer, Brian Salmons, Walter H. Günzburg, Christine Hohenadl
Format:	Article
Language:	English
Published:	Hindawi Limited 2008-01-01
Series:	Journal of Biomedicine and Biotechnology
Online Access:	http://dx.doi.org/10.1155/2008/683505

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