Gut dysbiosis and mortality in hemodialysis patients
Abstract Little is known about the relationship between gut dysbiosis, inflammation, and adverse outcomes in patients with chronic kidney disease. We examined the association of microbial diversity with all-cause mortality in hemodialysis patients. The gut microbiota was assessed by 16S ribosomal RN...
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2021-03-01
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doaj-a7595e65c443421181e5bce1768933392021-03-11T12:50:28ZengNature Publishing Groupnpj Biofilms and Microbiomes2055-50082021-03-01711910.1038/s41522-021-00191-xGut dysbiosis and mortality in hemodialysis patientsTing-Yun Lin0Ping-Hsun Wu1Yi-Ting Lin2Szu-Chun Hung3Division of Nephrology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and School of Medicine, Tzu Chi UniversityDivision of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical UniversityFaculty of Medicine, College of Medicine, Kaohsiung Medical UniversityDivision of Nephrology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and School of Medicine, Tzu Chi UniversityAbstract Little is known about the relationship between gut dysbiosis, inflammation, and adverse outcomes in patients with chronic kidney disease. We examined the association of microbial diversity with all-cause mortality in hemodialysis patients. The gut microbiota was assessed by 16S ribosomal RNA gene sequencing. During a median follow-up of 2.1 years, the adjusted risk of death among patients with higher diversity (above median) was 74% lower than that among patients with lower diversity (below median). We then compared the microbial composition between nonsurvivors and survivors in a matched case-control study. We observed significantly lower microbial diversity and higher proinflammatory cytokines among nonsurvivors than survivors. Specifically, the relative abundance of Succinivibrio and Anaerostipes, two short-chain fatty acid-producing bacteria, was markedly reduced in nonsurvivors. Thus, a unique gut microbial composition is associated with an increased risk of mortality among hemodialysis patients and may be used to identify subjects with a poor prognosis.https://doi.org/10.1038/s41522-021-00191-x |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ting-Yun Lin Ping-Hsun Wu Yi-Ting Lin Szu-Chun Hung |
spellingShingle |
Ting-Yun Lin Ping-Hsun Wu Yi-Ting Lin Szu-Chun Hung Gut dysbiosis and mortality in hemodialysis patients npj Biofilms and Microbiomes |
author_facet |
Ting-Yun Lin Ping-Hsun Wu Yi-Ting Lin Szu-Chun Hung |
author_sort |
Ting-Yun Lin |
title |
Gut dysbiosis and mortality in hemodialysis patients |
title_short |
Gut dysbiosis and mortality in hemodialysis patients |
title_full |
Gut dysbiosis and mortality in hemodialysis patients |
title_fullStr |
Gut dysbiosis and mortality in hemodialysis patients |
title_full_unstemmed |
Gut dysbiosis and mortality in hemodialysis patients |
title_sort |
gut dysbiosis and mortality in hemodialysis patients |
publisher |
Nature Publishing Group |
series |
npj Biofilms and Microbiomes |
issn |
2055-5008 |
publishDate |
2021-03-01 |
description |
Abstract Little is known about the relationship between gut dysbiosis, inflammation, and adverse outcomes in patients with chronic kidney disease. We examined the association of microbial diversity with all-cause mortality in hemodialysis patients. The gut microbiota was assessed by 16S ribosomal RNA gene sequencing. During a median follow-up of 2.1 years, the adjusted risk of death among patients with higher diversity (above median) was 74% lower than that among patients with lower diversity (below median). We then compared the microbial composition between nonsurvivors and survivors in a matched case-control study. We observed significantly lower microbial diversity and higher proinflammatory cytokines among nonsurvivors than survivors. Specifically, the relative abundance of Succinivibrio and Anaerostipes, two short-chain fatty acid-producing bacteria, was markedly reduced in nonsurvivors. Thus, a unique gut microbial composition is associated with an increased risk of mortality among hemodialysis patients and may be used to identify subjects with a poor prognosis. |
url |
https://doi.org/10.1038/s41522-021-00191-x |
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