Subtracting the sequence bias from partially digested MNase-seq data reveals a general contribution of TFIIS to nucleosome positioning

Subtracting the sequence bias from partially digested MNase-seq data reveals a general contribution of TFIIS to nucleosome positioning

Abstract Background TFIIS stimulates RNA cleavage by RNA polymerase II and promotes the resolution of backtracking events. TFIIS acts in the chromatin context, but its contribution to the chromatin landscape has not yet been investigated. Co-transcriptional chromatin alterations include subtle chang...

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Bibliographic Details
Main Authors: Gabriel Gutiérrez, Gonzalo Millán-Zambrano, Daniel A. Medina, Antonio Jordán-Pla, José E. Pérez-Ortín, Xenia Peñate, Sebastián Chávez
Format: Article
Language:English
Published: BMC 2017-12-01
Series:Epigenetics & Chromatin
Subjects:
Nucleosome mapping
MNase-seq
MNase-sensitive nucleosomes
TFIIS
Nucleosomal fuzziness
Online Access:http://link.springer.com/article/10.1186/s13072-017-0165-x

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