Efficacy of Paclitaxel in a Patient with Inoperable Pulmonary Vein Leiomyosarcoma
Pulmonary vein leiomyosarcoma is extremely rare and has a poor prognosis. Surgical resection with a wide margin seems to offer the only chance of cure. The role of adjuvant therapy is controversial, and the exact efficacy of chemotherapy has not been observed. In this report, we present an 18-year-o...
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doaj-a75f3b9ede344faa900fb90c214f811b2020-11-24T23:53:51ZengKarger PublishersCase Reports in Oncology1662-65752017-06-0110256457010.1159/000477657477657Efficacy of Paclitaxel in a Patient with Inoperable Pulmonary Vein LeiomyosarcomaShinji KounamiHiroshi TsujimotoTakayuki IchikawaMegumi YoshiyamaMitsuru YuzakiYoshiharu NishimuraHiroyuki SuzukiPulmonary vein leiomyosarcoma is extremely rare and has a poor prognosis. Surgical resection with a wide margin seems to offer the only chance of cure. The role of adjuvant therapy is controversial, and the exact efficacy of chemotherapy has not been observed. In this report, we present an 18-year-old male patient with pulmonary vein leiomyosarcoma in whom the use of paclitaxel (PAX) proved to be effective. Because the tumor originated from the left superior pulmonary vein and diffused into the left atrial wall and the junction of the right superior pulmonary vein and left atrium, the en bloc excision of the tumor was impossible. The first-line chemotherapy, including ifosfamide, doxorubicin, and dacarbazine, in conjugation with radiation therapy could not demonstrate any effect on the tumor size. However, the following PAX-containing regimen provided complete regression of the tumor. After PAX-based high-dose chemotherapy with autologous peripheral blood stem cell transplantation, the patient showed complete remission for 2 years. Although he suffered metastatic recurrences and died 4 years after the onset of symptoms, our patient’s clinical course clearly reveals the efficacy of PAX.http://www.karger.com/Article/FullText/477657High-dose chemotherapyPeripheral blood stem cell transplantationLeiomyosarcomaPaclitaxelPulmonary vein |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shinji Kounami Hiroshi Tsujimoto Takayuki Ichikawa Megumi Yoshiyama Mitsuru Yuzaki Yoshiharu Nishimura Hiroyuki Suzuki |
spellingShingle |
Shinji Kounami Hiroshi Tsujimoto Takayuki Ichikawa Megumi Yoshiyama Mitsuru Yuzaki Yoshiharu Nishimura Hiroyuki Suzuki Efficacy of Paclitaxel in a Patient with Inoperable Pulmonary Vein Leiomyosarcoma Case Reports in Oncology High-dose chemotherapy Peripheral blood stem cell transplantation Leiomyosarcoma Paclitaxel Pulmonary vein |
author_facet |
Shinji Kounami Hiroshi Tsujimoto Takayuki Ichikawa Megumi Yoshiyama Mitsuru Yuzaki Yoshiharu Nishimura Hiroyuki Suzuki |
author_sort |
Shinji Kounami |
title |
Efficacy of Paclitaxel in a Patient with Inoperable Pulmonary Vein Leiomyosarcoma |
title_short |
Efficacy of Paclitaxel in a Patient with Inoperable Pulmonary Vein Leiomyosarcoma |
title_full |
Efficacy of Paclitaxel in a Patient with Inoperable Pulmonary Vein Leiomyosarcoma |
title_fullStr |
Efficacy of Paclitaxel in a Patient with Inoperable Pulmonary Vein Leiomyosarcoma |
title_full_unstemmed |
Efficacy of Paclitaxel in a Patient with Inoperable Pulmonary Vein Leiomyosarcoma |
title_sort |
efficacy of paclitaxel in a patient with inoperable pulmonary vein leiomyosarcoma |
publisher |
Karger Publishers |
series |
Case Reports in Oncology |
issn |
1662-6575 |
publishDate |
2017-06-01 |
description |
Pulmonary vein leiomyosarcoma is extremely rare and has a poor prognosis. Surgical resection with a wide margin seems to offer the only chance of cure. The role of adjuvant therapy is controversial, and the exact efficacy of chemotherapy has not been observed. In this report, we present an 18-year-old male patient with pulmonary vein leiomyosarcoma in whom the use of paclitaxel (PAX) proved to be effective. Because the tumor originated from the left superior pulmonary vein and diffused into the left atrial wall and the junction of the right superior pulmonary vein and left atrium, the en bloc excision of the tumor was impossible. The first-line chemotherapy, including ifosfamide, doxorubicin, and dacarbazine, in conjugation with radiation therapy could not demonstrate any effect on the tumor size. However, the following PAX-containing regimen provided complete regression of the tumor. After PAX-based high-dose chemotherapy with autologous peripheral blood stem cell transplantation, the patient showed complete remission for 2 years. Although he suffered metastatic recurrences and died 4 years after the onset of symptoms, our patient’s clinical course clearly reveals the efficacy of PAX. |
topic |
High-dose chemotherapy Peripheral blood stem cell transplantation Leiomyosarcoma Paclitaxel Pulmonary vein |
url |
http://www.karger.com/Article/FullText/477657 |
work_keys_str_mv |
AT shinjikounami efficacyofpaclitaxelinapatientwithinoperablepulmonaryveinleiomyosarcoma AT hiroshitsujimoto efficacyofpaclitaxelinapatientwithinoperablepulmonaryveinleiomyosarcoma AT takayukiichikawa efficacyofpaclitaxelinapatientwithinoperablepulmonaryveinleiomyosarcoma AT megumiyoshiyama efficacyofpaclitaxelinapatientwithinoperablepulmonaryveinleiomyosarcoma AT mitsuruyuzaki efficacyofpaclitaxelinapatientwithinoperablepulmonaryveinleiomyosarcoma AT yoshiharunishimura efficacyofpaclitaxelinapatientwithinoperablepulmonaryveinleiomyosarcoma AT hiroyukisuzuki efficacyofpaclitaxelinapatientwithinoperablepulmonaryveinleiomyosarcoma |
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